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Woong-Ki Kim
Eastern Virginia Medical School
VirologyImmunologySimian immunodeficiency virusMonocyteBiology
42Publications
17H-index
1,087Citations
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Publications 41
Newest
#1Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
#2Yueying Wang (EVMS: Eastern Virginia Medical School)
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 11 authors...
We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in myeloid cell populations that are the known target of SIV and HIV in the brain contribute to the lack of neonatal susceptibility to lentivirus-induced encephalitis. Using immunohistochemistry and immunofluorescenc...
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#1Muhammad Shahid (Cedars-Sinai Medical Center)H-Index: 10
#2Minhyung Kim (Cedars-Sinai Medical Center)H-Index: 3
Last. Jayoung Kim (Cedars-Sinai Medical Center)H-Index: 29
view all 7 authors...
PURPOSE: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have been contradictory results. This present study is designed to understand the regulatory mechanisms that drive the effects of pioglitazone on the bladder epithelial cells. METHODS: Labeled liquid chromatography-tandem mass spectrometry-based proteomics profiling characterized the global pr...
1 CitationsSource
#1Antonito T. Panganiban (Tulane University)H-Index: 4
#2Robert V. Blair (Tulane University)H-Index: 4
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 8 authors...
Zika virus (ZIKV) is a neurotropic virus that can cause neuropathy in adults and fetal neurologic malformation following infection of pregnant women. We used a nonhuman primate model, the Indian-origin Rhesus macaque (IRM), to gain insight into virus-associated hallmarks of ZIKV-induced adult neuropathy. We find that the virus causes prevalent acute and chronic neuroinflammation and chronic disruption of the blood-brain barrier (BBB) in adult animals. Infection results in significant, targeted, ...
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#1Derek L. Irons (EVMS: Eastern Virginia Medical School)H-Index: 2
#2Timothy Meinhardt (EVMS: Eastern Virginia Medical School)H-Index: 1
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 5 authors...
: In the present study, we investigated whether colony-stimulating factor 1 receptor (CSF1R) is expressed on brain macrophages and microglia in the human and macaque brain and whether it is upregulated and activated after lentivirus infection in vivo and contributes to development of encephalitic lesions. We examined, using multi-label and semi-quantitative immunofluorescence microscopy, the protein expression level and cellular localization of CSF1R in brain tissues from uninfected controls and...
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#1Elizabeth C. Delery (Tulane University)H-Index: 3
#2Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 12 authors...
Despite combination antiretroviral therapies making HIV a chronic rather than terminal condition for many people, the prevalence of HIV-associated neurocognitive disorders (HAND) is increasing. This is especially problematic for children living with HIV. Children diagnosed HAND rarely display the hallmark pathology of HIV encephalitis in adults, namely infected macrophages and multinucleated giant cells in the brain. This finding has also been documented in rhesus macaques infected perinatally w...
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#1Crystal R. Leibrand (VCU: Virginia Commonwealth University)H-Index: 4
#2Jason J. Paris (University of Mississippi)H-Index: 20
Last. MaryPeace McRae (VCU: Virginia Commonwealth University)H-Index: 9
view all 10 authors...
Poor antiretroviral penetration may contribute to human immunodeficiency virus (HIV) persistence within the brain and to neurocognitive deficits in opiate abusers. To investigate this problem, HIV-1 Tat protein and morphine effects on blood–brain barrier (BBB) permeability and drug brain penetration were explored using a conditional HIV-1 Tat transgenic mouse model. Tat and morphine effects on the leakage of fluorescently labeled dextrans (10-, 40-, and 70-kDa) into the brain were assessed. To e...
3 CitationsSource
: The intestinal tract is a primary barrier to invading pathogens and contains immune cells, including lymphocytes and macrophages. We previously reported that CD163+CD206- (single-positive [SP]) interstitial macrophages of the lung are short-lived and succumb early to SIV infection. Conversely, CD163+CD206+ (double-positive [DP]) alveolar macrophages are long-lived, survive after SIV infection, and may contribute to the virus reservoir. This report characterizes analogous populations of macroph...
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#1Diana G. Bohannon (EVMS: Eastern Virginia Medical School)H-Index: 2
#2Allen Ko (EVMS: Eastern Virginia Medical School)H-Index: 2
Last. Woong-Ki Kim (EVMS: Eastern Virginia Medical School)H-Index: 17
view all 5 authors...
Background Impairment of the blood–brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role for the Sonic hedgehog (Shh) signaling pathway in the maintenance of BBB integrity under both physiological and pathological conditions.
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#1Ziyuan He (Tulane University)H-Index: 1
#2Carolina Allers (Tulane University)H-Index: 3
Last. Marcelo J. Kuroda (Tulane University)H-Index: 25
view all 8 authors...
Neutrophils, basophils, and monocytes are continuously produced in bone marrow via myelopoiesis, circulate in blood, and are eventually removed from circulation to maintain homeostasis. To quantitate the kinetics of myeloid cell movement during homeostasis, we applied 5-bromo-2′-deoxyuridine pulse labeling in healthy rhesus macaques ( Macaca mulatta ) followed by hematology and flow cytometry analyses. Results were applied to a mathematical model, and the blood circulating half-life and daily pr...
2 CitationsSource
#2Adam R. FilipowiczH-Index: 3
Last. Woong-Ki KimH-Index: 17
view all 8 authors...
Objective: HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected individuals despite combination antiretroviral therapy. Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a newly identified host restriction factor that blocks the replication of HIV-1 and other retroviruses in myeloid cells. Cell cycle-regulated phosphorylation at residue Thr592 and viral protein X (Vpx)-mediated degradation of SAMHD1 have been shown to ...
3 CitationsSource
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