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Tatiana Gianni
University of Bologna
Herpesvirus glycoprotein BVirologyReceptorHerpes simplex virusBiology
26Publications
15H-index
678Citations
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Publications 26
Newest
#1Laura MenottiH-Index: 17
#2Valerio LeoniH-Index: 8
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#1Andrea VanniniH-Index: 7
#2Biljana PetrovicH-Index: 5
Last. Tatiana GianniH-Index: 15
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Source
#1Andrea Vannini (UNIBO: University of Bologna)H-Index: 7
#2Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
Last. Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
view all 8 authors...
Tumors utilize a number of effective strategies, including the programmed death 1/PD ligand 1 (PD-1/PD-L1) axis, to evade immune-mediated control of their growth. PD-L1 expression is mainly induced by IFN receptor signaling or constitutively induced. Integrins are an abundantly expressed class of proteins which play multiple deleterious roles in cancer and exert proangiogenic and prosurvival activities. We asked whether αvβ3-integrin positively regulates PD-L1 expression and the anticancer immun...
2 CitationsSource
#1Valerio LeoniH-Index: 8
#2Biljana PetrovicH-Index: 5
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3 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Biljana Petrovic (UNIBO: University of Bologna)H-Index: 5
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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1 CitationsSource
#1Biljana Petrovic (UNIBO: University of Bologna)H-Index: 5
#2Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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15 CitationsSource
The repertoire of herpesvirus receptors consists of nonintegrin and integrin molecules. Integrins interact with the conserved glycoproteins gH/gL or gB. This interaction is a conserved biology across the Herpesviridae family, likely directed to promote virus entry and endocytosis. Herpesviruses exploit this interaction to execute a range of critical functions that include (a) relocation of nonintegrin receptors (e.g., herpes simplex virus nectin1 and Kaposi's sarcoma–associated herpesvirus EphA2...
17 CitationsSource
#1Costanza Casiraghi (UNIBO: University of Bologna)H-Index: 4
#2Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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We report that αvβ3 integrin strongly affects the innate immune response in epithelial cells. αvβ3 integrin greatly increased the response elicited via plasma membrane Toll-like receptors (TLRs) by herpes simplex virus or bacterial ligands. The endosomal TLR3, not the cytosolic sensor interferon gamma-inducible protein 16 (IFI16), was also boosted by αvβ3 integrin. The boosting was exerted specifically by αvβ3 integrin but not by αvβ6 or αvβ8 integrin. Current and previous work indicates that in...
6 CitationsSource
#2Biljana PetrovicH-Index: 5
Last. Valentina GattaH-Index: 4
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Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is often the case. To overcome the attenuation limits, a strategy is to render the virus highly cancer-speci...
14 CitationsSource
BIOPHYSICS. For the article "Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli," by Che Ma and Geoffrey Chang, which appeared in issue 9, March 2, 2004, of Proc NatlAcad Sei USA (101:2852-2857; first published Febru ary 17, 2004; 10.1073/pnas.0400137101), the authors wish to note the following: "We have recently discovered that the structure was determined in the incorrect hand. An in-house data reduction program introduced a change in sign for anom alous differ...
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