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Sonoko Yasui
University of Tokushima
Insulin receptorEndocrinologyVascular smooth muscleMedicinePotassium channel
16Publications
8H-index
147Citations
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Publications 16
Newest
#1Sayaka Matsuura (University of Tokushima)H-Index: 2
#2Yumiko ShiraiH-Index: 2
Last. Yasuhiro Hamada (University of Tokushima)H-Index: 22
view all 12 authors...
Serum transthyretin (TTR), also known as prealbumin, is a reliable nutritional indicator and an independent prognostic factor for maintenance hemodialysis patients. However, we recently reported that serum TTR levels did not affect protein−energy wasting (PEW). In this study, we investigated factors affecting serum TTR levels in 60 maintenance hemodialysis patients. The patients were divided into High-TTR and Low-TTR groups according to the median serum TTR level. Albumin levels were significant...
2 CitationsSource
Objective: The International Society of Renal Nutrition and Metabolism (ISRNM) has recently recommended the use of the term 〞protein-energy wasting〞 (PEW). PEW is a state of malnutrition with decreased body stores of protein and energy fuel in hemodialysis patients and is known as a risk factor for morbidity and mortality. We examined the prevalence of PEW and the characteristics of PEW patients in a hemodialysis center in Japan. Methods: Fifty-nine outpatients undergoing maintenance hemodialysi...
6 CitationsSource
#1Sonoko YasuiH-Index: 8
#2Yumiko ShiraiH-Index: 2
Last. Yasuhiro HamadaH-Index: 22
view all 10 authors...
Source
#1Sonoko YasuiH-Index: 8
#2Yumiko ShiraiH-Index: 2
Last. Yasuhiro HamadaH-Index: 22
view all 6 authors...
1 CitationsSource
#1Kazuaki Mawatari (University of Tokushima)H-Index: 16
#2Emiko Yoshioka (University of Tokushima)H-Index: 3
Last. Yutaka Nakaya (University of Tokushima)H-Index: 46
view all 12 authors...
Abstract Left atrial (LA) thrombosis is an important cause of systemic embolization. The SPORTS rat model of LA thrombi (Spontaneously-Running Tokushima-Shikoku), which have a unique characteristic of high voluntary wheel running, was previously established. The aim of the present study was to investigate how SPORTS rats develop LA thrombi. Nitric oxide (NO) produced from cardiovascular endothelial cells plays an important protective role in the local regulation of blood flow, vascular tone, and...
9 CitationsSource
#1Yasuhiro HamadaH-Index: 22
#2Sonoko YasuiH-Index: 8
Last. Makoto UsamiH-Index: 19
view all 3 authors...
Source
#1Sonoko Yasui (University of Tokushima)H-Index: 8
#2Kazuaki Mawatari (University of Tokushima)H-Index: 16
Last. Yutaka Nakaya (University of Tokushima)H-Index: 46
view all 8 authors...
Both reactive oxygen species (ROS) and insulin resistance have been reported to play essential pathophysiological roles in cardiovascular diseases, such as hyperten- sion and atherosclerosis. However, the mechanistic link between ROS and insulin resis- tance in the vasculature remains unclear. Recently we have shown that insulin causes membrane hyperpolarization via ATP-sensitive potassium (KATP) channel activation, which is mediated by phosphatidylinositol 3-kinase (PI3-K) in cultured vascular ...
6 CitationsSource
#1Hiroko Furukawa (University of Tokushima)H-Index: 6
#2Kazuaki Mawatari (University of Tokushima)H-Index: 16
Last. Yutaka Nakaya (University of Tokushima)H-Index: 46
view all 9 authors...
Angiotensin II is a peptide hormone with strong vasoconstrictive action, and recent reports have shown that Angiotensin II receptor type 1 antagonists (angiotensin II receptor blockers) also improve glucose metabolism. The angiotensin II receptor blocker telmisartan acts as an agonistic ligand of the peroxisome proliferator-activated receptor gamma (PPARγ). In this study, we investigated the effects of telmisartan on glucose uptake and insulin sensitivity in 3T3-L1 adipocytes and compared it wit...
10 CitationsSource
#1Atsushi Hattori (University of Tokushima)H-Index: 7
#2Kazuaki Mawatari (University of Tokushima)H-Index: 16
Last. Yutaka Nakaya (University of Tokushima)H-Index: 46
view all 15 authors...
We established a new animal model called SPORTS (Spontaneously-Running Tokushima-Shikoku) rats, which show high-epinephrine (Epi) levels. Recent reports show that Epi activates adenosine monophosphate (AMP)–activated protein kinase (AMPK) in adipocytes. Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in fatty acid synthesis, and the enzymatic activity is suppressed when its Ser-79 is phosphorylated by AMPK. The aim of this study was to investigate the in vivo effect of Epi on ACC and ab...
17 CitationsSource
#1Yinhua (University of Tokushima)H-Index: 2
#2Nagakatsu Harada (University of Tokushima)H-Index: 21
Last. Yutaka Nakaya (University of Tokushima)H-Index: 46
view all 8 authors...
Objectives : To clarify the underlying mechanisms of L-DOPA induced vasocon- striction in rat aorta. Methods : The effect of L-DOPA on phenylephrine-induced contrac- tile force of blood vessels was examined in vitro using rat aortic ring preparations by iso- metric tension experiment. Involvement of nitric oxide (NO) in the effect of L-DOPA on vascular smooth muscle was studied by using Nω-Nitro-L-arginine (L-NNA), Sodium ni- troprusside (SNP) in endothelium-intact and endothelium-denuded aortic...
1 CitationsSource
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