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Jun-Ichi Hayashi
University of Tsukuba
146Publications
39H-index
6,628Citations
Publications 146
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#1Emi Ogasawara (University of Tsukuba)H-Index: 6
#2Kazuto Nakada (University of Tsukuba)H-Index: 30
Last.Jun-Ichi Hayashi (University of Tsukuba)H-Index: 39
view all 5 authors...
Marked accumulation of mitochondrial DNA (mtDNA) with a particular pathogenic mutation is necessary for the mutant mtDNA to express its pathogenicity as mitochondrial respiration defects. However, the nuclear genome background, or the physiological status, or both, might also be important for the pathogenic regulation of mutant mtDNAs, because most mitochondrial function is controlled by polypeptides encoded in the nuclear genome. To test this, we generated diabetic mice carrying pathogenic mtDN...
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#1Haruna Tani (University of Tsukuba)H-Index: 1
#2Sakiko Ohnishi (University of Tsukuba)H-Index: 2
Last.Jun-Ichi Hayashi (University of Tsukuba)H-Index: 39
view all 10 authors...
Accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for human aging and age-associated mitochondrial respiration defects. However, our previous findings suggested an alternative hypothesis of human aging—that epigenetic changes but not mutations regulate age-associated mitochondrial respiration defects, and that epigenetic downregulation of nuclear-coded genes responsible for mitochondrial translation [e.g., glycine C-acetyltransferase (GCAT), serin...
5 CitationsSource
#1Chisato Sumi (Kansai Medical University)H-Index: 5
#2Akihisa Okamoto (Kansai Medical University)H-Index: 5
Last.Kiichi Hirota (Kansai Medical University)H-Index: 44
view all 12 authors...
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propofol for prolonged periods. In vivo and in vitro evidence suggests that the propofol toxicity is related to the impaired mitochondrial function. However, underlying molecular mechanisms remain unknown....
8 CitationsSource
#1Takayuki Mito (University of Tsukuba)H-Index: 5
#2Haruna Tani (University of Tsukuba)H-Index: 1
Last.Jun-Ichi Hayashi (University of Tsukuba)H-Index: 39
view all 6 authors...
Source
#1Nobuko KoshikawaH-Index: 14
#2Miho Akimoto (Teikyo University)H-Index: 9
Last.Keizo Takenaga (Shimane University)H-Index: 31
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Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to enhance the invasive and metastatic ability of various tumour cells in animal experiments. However, it is unknown whether single-nucleotide variants (SNVs) of the ND genes that decrease complex I activity are involved in distant metastasis in human clinical samples. Here, we demonstrated the enha...
5 CitationsSource
#1Akinori Shimizu (Fukuoka University)H-Index: 5
#2Haruna Tani (University of Tsukuba)H-Index: 1
Last.Jun-Ichi Hayashi (University of Tsukuba)H-Index: 39
view all 10 authors...
Abstract In a previous study, we generated transmitochondrial P29mtSAMP1 cybrids, which had nuclear DNA from the C57BL6 (referred to as B6) mouse strain-derived P29 tumor cells and mitochondrial DNA (mtDNA) exogenously-transferred from the allogeneic strain SAMP1. Because P29mtSAMP1 cybrids did not form tumors in syngeneic B6 mice, we proposed that allogeneic SAMP1 mtDNA suppressed tumor formation of P29mtSAMP1 cybrids. To test this hypothesis, current study generated P29mt(sp)B6 cybrids carryin...
Source
#1Chisato Sumi (Kansai Medical University)H-Index: 5
#2Akihisa Okamoto (Kansai Medical University)H-Index: 5
Last.Kiichi Hirota (Kansai Medical University)H-Index: 44
view all 12 authors...
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia in operating rooms and for sedation in intensive care units. Although there is no widely accepted definition of propofol infusion syndrome (PRIS), PRIS is defined as the development of metabolic acidosis, rhabdomyolysis, hyperkalemia, hepatomegaly, renal failure, arrhythmia, and progressive cardiac failure. In vitro evidence suggests that PRIS is related to the impaired mitoc...
Source
#1Nurun Nahar Borna (Saitama Medical University)H-Index: 2
#2Yoshihito Kishita (Saitama Medical University)H-Index: 11
Last.Yasushi Okazaki (Saitama Medical University)H-Index: 53
view all 14 authors...
A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy
2 CitationsSource
#1Yo Homma (ENVIRON)
#2Shun Katada (ENVIRON)
Last.Kaori IshikawaH-Index: 14
view all 10 authors...
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