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Annette T. Hastie
Wake Forest University
ImmunologyAsthmaSputumLungMedicine
99Publications
26H-index
2,696Citations
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Publications 108
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#1Victor E. Ortega (Wake Forest University)H-Index: 11
#2D. Kim (USF: University of South Florida)
Last. Igor Barjaktarevic (UCLA: University of California, Los Angeles)H-Index: 9
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#1Laura M. RaffieldH-Index: 12
#2Hong DangH-Index: 12
Last. Alejandro P. ComellasH-Index: 24
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Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, leaving investigators unsure when cross-assay comparisons are appropriate. We explored the correlation of results from immunoassays with relative protein quantification by SOMAscan. For 63 proteins assessed in two chronic obstructive pulmonary ...
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#1Michael C. Peters (UCSF: University of California, San Francisco)H-Index: 11
#2S. SajuthiH-Index: 1
Last. Mats W Johansson (University of Wisconsin Colleges)
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BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by SARS-coronavirus 2 (SARS-CoV-2). Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among asthma patients may identify subgroups at risk for COVID19 morbidity. METHODS: We analyzed gene expression for ACE2 and TMPRSS2, and for intercellular adhesion molecule 1 (ICAM-1)(rhinovirus recep...
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#1Annette T. Hastie (Wake Forest University)H-Index: 26
#2David T. Mauger (PSU: Pennsylvania State University)H-Index: 55
Last. Wendy C. Moore (Wake Forest University)H-Index: 35
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#1Samuel Y. Ash (Brigham and Women's Hospital)H-Index: 8
#2Gonzalo Vegas Sanchez-Ferrero (Brigham and Women's Hospital)H-Index: 3
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Abstract Background Relative enlargement of the pulmonary artery (PA) on chest computed tomography (CT) is associated with respiratory exacerbations in patients with chronic obstructive pulmonary disease or cystic fibrosis. We sought to determine if similar findings were present in patients with asthma and if they were explained by differences in ventricular size. Methods We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimat...
1 CitationsSource
#1Robert M. Burkes (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Agathe Ceppe (UNC: University of North Carolina at Chapel Hill)H-Index: 3
Last. M. Bradley Drummond (UNC: University of North Carolina at Chapel Hill)H-Index: 18
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Abstract Introduction The relationship between 25-hydroxy-vitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations between baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations. Methods Serum 25-OH-vitamin D level was measured in stored samples from 1609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuousl...
1 CitationsSource
#1William Z. Zhang (NewYork–Presbyterian Hospital)H-Index: 1
#1W. ZhangH-Index: 2
Last. Mary E. ChoiH-Index: 25
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BACKGROUNDMitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly in various bodily fluids. Despite evidence for the increased prevalence of chronic kidney disease in COPD subjects and for mitochondrial dysfunction in the kidneys of murine COPD models, whether urine mtDNA (u-mtDNA) associates with measures of disease severity in COPD is unknown....
1 CitationsSource
#1Xingnan Li (UA: University of Arizona)H-Index: 19
#2Annette T. Hastie (Wake Forest University)H-Index: 26
Last. Eugene R. Bleecker (UA: University of Arizona)H-Index: 94
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#1Matthew S. GodwinH-Index: 1
#2Kristen M. ReederH-Index: 2
Last. Chad SteeleH-Index: 45
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