Match!
Fuwu Zhang
National Institutes of Health
NanoparticleOrganic chemistryChemistryMaterials sciencePolymer
62Publications
23H-index
1,414Citations
What is this?
Publications 64
Newest
#1Yen-Nan Lin (A&M: Texas A&M University)H-Index: 3
#2Mahmoud Elsabahy (Assiut University)H-Index: 23
Last. Lu Su (TU/e: Eindhoven University of Technology)H-Index: 10
view all 11 authors...
Biomimetic-cell-membrane-camouflaged polymeric nanocarriers, possessing advantages related to the functional diversity of natural cell membranes and the physicochemical tailorability of synthetic p...
Source
#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Guangming Lu (NU: Nanjing University)H-Index: 46
view all 12 authors...
Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have no or low immunogenicity. Here, a bi-adjuvant neoantigen nanovaccine (banNV) that codelivered a peptide neoantigen (Adpgk) with two adjuvants [Toll-like receptor (TLR) 7/8 agonist R848 and TLR9 agonist CpG] was developed for potent cancer immunotherapy. Specifically, banNVs were prepared by a nanotemplated synthesis of concatemer CpG, nanocondensation with cationic...
1 CitationsSource
#1Weijing Yang (CSU: Central South University)H-Index: 2
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 16 authors...
Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide (PEG-b-cPPT) can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through pre-apoptotic exposure of calreticulin (CRT). After co-encapsulation of a photosensitizer, 2-(1-hexyloxyethy...
Source
#1Richen Li (A&M: Texas A&M University)H-Index: 7
#2Hai Wang (A&M: Texas A&M University)H-Index: 9
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 74
view all 12 authors...
As a rapid, controllable, and easily transferrable approach to the preparation of antimicrobial nanoparticle systems, a one-step, light-driven procedure was developed to produce asymmetric hybrid inorganic–organic nanoparticles (NPs) directly from a homogeneous Ag/polymer mixture. An amphiphilic triblock polymer was designed and synthesized to build biocompatible NPs, consisting of poly(ethylene oxide) (PEO), carboxylic acid-functionalized polyphosphoester (PPE), and poly(l-lactide) (PLLA). Unex...
2 CitationsSource
#1Zhimei He (NU: Nanjing University)H-Index: 4
#2Xiaolin Huang (NCU: Nanchang University)H-Index: 1
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 14 authors...
2 CitationsSource
#1Weijing Yang (CSU: Central South University)H-Index: 2
#2Guizhi Zhu (NIH: National Institutes of Health)H-Index: 38
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 18 authors...
A cancer vaccine is an important form of immunotherapy. Given their effectiveness for antigen processing and presentation, dendritic cells (DCs) have been exploited in the development of a therapeutic vaccine. Herein, a versatile polymersomal nanoformulation that enables generation of tumor-associated antigens (TAAs) and simultaneously serves as adjuvant for an in situ DC vaccine is reported. The chimeric cross-linked polymersome (CCPS) is acquired from self-assembly of a triblock copolymer, pol...
2 CitationsSource
#1Qingquan Chen (Texas A&M Health Science Center)H-Index: 1
#2Kush N. Shah (Texas A&M Health Science Center)H-Index: 1
Last. Carolyn L. Cannon (Texas A&M Health Science Center)H-Index: 30
view all 9 authors...
Pseudomonas aeruginosa has been detected in the lungs of ∼50% of patients with cystic fibrosis (CF), including 20% of adult CF patients. The majority of these adult patients harbor multi-drug resistant (MDR) strains, limiting the available treatment options. Silver has long been used as a broad-spectrum antimicrobial agent with a low incidence of resistance. Despite low toxicity, poor availability of silver cations mandates a high dosage to effectively eradicate infections. To address this short...
Source
#1Sheng Wang (Guangzhou Medical University)H-Index: 24
#2Zhantong Wang (NIH: National Institutes of Health)H-Index: 19
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 10 authors...
7 CitationsSource
#1Zhimei He (NU: Nanjing University)H-Index: 4
#2Yunlu Dai (UM: University of Macau)H-Index: 36
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 14 authors...
8 CitationsSource
#1Guocan Yu (NIH: National Institutes of Health)H-Index: 35
#2Shan Yu (ZJU: Zhejiang University)H-Index: 9
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 17 authors...
Photodynamic therapy is an effective alternative to traditional treatments due to its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it is still challenging to design photosensitizers with high singlet oxygen (1O2) quantum yields (QY) due to severe aggregation of the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis-(PEt3)2Pt(OTf)2 as the building block to imp...
11 CitationsSource
1234567