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Stella M. Valenzuela
University of Technology, Sydney
85Publications
28H-index
3,389Citations
Publications 86
Newest
Abstract Surface modification to obtain high dispersion stability and biocompatibility is a key factor for bio-application of upconversion nanoparticles (UCNPs). A systematic study of UCNPs modified with four hydrophilic molecules, separately comparing their dispersion stability in biological buffers and cellular biocompatibility is reported here. The results show that carboxyl-functionalized UCNPs (modified by 3,4-dihydrocinnamic acid (DHCA) or poly(monoacryloxyethyl phosphate (MAEP)) with nega...
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#1Khondker R. Hossain (UTS: University of Technology, Sydney)H-Index: 5
#2Daniel R. Turkewitz (UTS: University of Technology, Sydney)
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
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Abstract Background Sterols have been reported to modulate conformation and hence the function of several membrane proteins. One such group is the Chloride Intracellular Ion Channel (CLIC) family of proteins. The CLIC protein family consists of six evolutionarily conserved protein members in vertebrates. These proteins exist as both monomeric soluble proteins and as membrane bound proteins. To date, the structure of their membrane-bound form remains unknown. In addition to several studies indica...
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#1Hui Chen (UTS: University of Technology, Sydney)H-Index: 24
#2Jane P. M. Ng (UTS: University of Technology, Sydney)H-Index: 1
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
view all 5 authors...
Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were admini...
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#1Hui Chen (UTS: University of Technology, Sydney)H-Index: 24
#2Jane P. M. Ng (UTS: University of Technology, Sydney)H-Index: 1
Last.Stella M. Valenzuela (UTS: University of Technology, Sydney)H-Index: 28
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Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following intraperito...
4 CitationsSource
#1Hui ChenH-Index: 24
Last.Stella M. ValenzuelaH-Index: 28
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#2Joshua ChouH-Index: 13
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Gentamicin sulphate is a potent antibiotic, widely used by clinicians to treat Staphylococcus aureus bacterial complications in orthopaedic surgery and osteomyelitis. Antibiotics as administered are poorly localised and can accumulate with toxic effects. Achieving a better targeted release and controlled dosage has been an ongoing unmet microengineering challenge.In this study we evaluated the antibiotic release potential of beta tricalcium phosphate (β-TCP) micro and macrospheres to eradicate S...
#1Yinghui ChenH-Index: 4
#2Hien T. T. DuongH-Index: 25
Last.Dayong JinH-Index: 31
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Sensitivity is the key in optical detection of low-abundant analytes, such as circulating RNA or DNA. The enzyme Exonuclease III (Exo III) is a useful tool in this regard; its ability to recycle target DNA molecules results in markedly improved detection sensitivity. Lower limits of detection may be further achieved if the detection background of autofluorescence can be removed. Here we report an ultrasensitive and specific method to quantify trace amounts of DNA analytes in a wash-free suspensi...
10 CitationsSource
#1Kerem Bray (UTS: University of Technology, Sydney)H-Index: 6
#2Leonard Cheung (UTS: University of Technology, Sydney)H-Index: 1
Last.Olga Shimoni (UTS: University of Technology, Sydney)H-Index: 10
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We report on the sizable production of fluorescent nanodiamonds (FNDs) containing a near infrared (NIR) color center – namely the silicon vacancy (SiV) defect, and their first demonstration inside cells for bio-imaging. We further demonstrate a concept of multi-color bio-imaging using FNDs to investigate intercellular processes using two types of FNDs. Due to their specific spectral properties, SiV FNDs can be distinguished from common nitrogen-vacancy (NV) FNDs and show a distinct initial sprea...
2 CitationsSource
#2Stephen A. HoltH-Index: 21
Last.Stella M. ValenzuelaH-Index: 28
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CLIC1 belongs to the ubiquitous family of chloride intracellular ion channel proteins that are evolutionarily conserved across species. The CLICs are unusual in that they exist mainly as soluble proteins but possess the intriguing property of spontaneous conversion from the soluble to an integral membrane-bound form. This conversion is regulated by the membrane lipid composition, especially by cholesterol, together with external factors such as oxidation and pH. However, the precise physiologica...
4 CitationsSource
#1Olga ShimoniH-Index: 10
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