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Stella M. Valenzuela
University of Technology, Sydney
81Publications
26H-index
3,241Citations
Publications 81
Newest
Published on Dec 1, 2018in Journal of Nanobiotechnology 5.34
Hui Chen21
Estimated H-index: 21
(UTS: University of Technology, Sydney),
Jane P. M. Ng1
Estimated H-index: 1
(UTS: University of Technology, Sydney)
+ 2 AuthorsStella M. Valenzuela26
Estimated H-index: 26
(UTS: University of Technology, Sydney)
Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were admini...
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Published on Dec 1, 2018in Journal of Nanobiotechnology 5.34
Hui Chen21
Estimated H-index: 21
(UTS: University of Technology, Sydney),
Jane P. M. Ng1
Estimated H-index: 1
(UTS: University of Technology, Sydney)
+ 7 AuthorsStella M. Valenzuela26
Estimated H-index: 26
(UTS: University of Technology, Sydney)
Background Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following ...
2 Citations Source Cite
Published on Feb 21, 2018
Lawrence Kohan1
Estimated H-index: 1
,
Kohan Lawrence + 4 AuthorsOtsuka Makoto
Gentamicin sulphate is a potent antibiotic, widely used by clinicians to treat Staphylococcus aureus bacterial complications in orthopaedic surgery and osteomyelitis. Antibiotics as administered are poorly localised and can accumulate with toxic effects. Achieving a better targeted release and controlled dosage has been an ongoing unmet microengineering challenge.In this study we evaluated the antibiotic release potential of beta tricalcium phosphate (β-TCP) micro and macrospheres to eradicate S...
Published on Jan 2, 2018in Analytical Chemistry 6.35
Yinghui Chen3
Estimated H-index: 3
,
Hien Thi Thu Duong25
Estimated H-index: 25
+ 5 AuthorsDayong Jin29
Estimated H-index: 29
Sensitivity is the key in optical detection of low-abundant analytes, such as circulating RNA or DNA. The enzyme Exonuclease III (Exo III) is a useful tool in this regard; its ability to recycle target DNA molecules results in markedly improved detection sensitivity. Lower limits of detection may be further achieved if the detection background of autofluorescence can be removed. Here we report an ultrasensitive and specific method to quantify trace amounts of DNA analytes in a wash-free suspensi...
5 Citations Source Cite
Published on Oct 31, 2017in Langmuir 3.68
Khondker R. Hossain4
Estimated H-index: 4
,
Stephen A. Holt21
Estimated H-index: 21
+ 2 AuthorsStella M. Valenzuela26
Estimated H-index: 26
CLIC1 belongs to the ubiquitous family of chloride intracellular ion channel proteins that are evolutionarily conserved across species. The CLICs are unusual in that they exist mainly as soluble proteins but possess the intriguing property of spontaneous conversion from the soluble to an integral membrane-bound form. This conversion is regulated by the membrane lipid composition, especially by cholesterol, together with external factors such as oxidation and pH. However, the precise physiologica...
2 Citations Source Cite
Published on Oct 2, 2017
Olga Shimoni10
Estimated H-index: 10
,
Stella M. Valenzuela26
Estimated H-index: 26
Published on Apr 1, 2017in Nature Communications 11.88
Juan Ramon Hernandez-Fernaud10
Estimated H-index: 10
,
Elena Ruengeler1
Estimated H-index: 1
+ 26 AuthorsIain R. Macpherson12
Estimated H-index: 12
The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of the CAF secretome. Secreted CLIC3 promotes invasive behaviour of endothelial cells to drive angiogenesis and increases invasiveness of cancer cells both in vivo and in 3D cell ...
12 Citations Source Cite
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