Fabrizio Benedetti
University of Turin
Physical therapyPlaceboNoceboAnesthesiaMedicine
What is this?
Publications 282
#1Giacomo RossettiniH-Index: 4
#2Eleonora Maria Camerone (UNITO: University of Turin)
Last. Marco TestaH-Index: 8
view all 5 authors...
Background Placebo and nocebo effects embody psychoneurobiological phenomena where behavioural, neurophysiological, perceptive and cognitive changes occur during the therapeutic encounter in the healthcare context. Placebo effects are produced by a positive healthcare context; while nocebo effects are consequences of negative healthcare context. Historically, placebo, nocebo and context-related effects were considered as confounding elements for clinicians and researchers. In the last two decade...
#1Fabrizio Benedetti (UNITO: University of Turin)H-Index: 61
#2Elisa Frisaldi (UNITO: University of Turin)H-Index: 10
Last. Aziz Shaibani (BCM: Baylor College of Medicine)H-Index: 11
view all 5 authors...
The biopsychosocial model claims that illness is generated by biological, psychological, and social factors. The nocebo response, particularly nocebo hyperalgesia, is an excellent model and approach to understand these effects and their psychophysiological underpinnings, as nocebos are made of negative psychological and social factors, such as negative expectations and social interactions. There is today experimental evidence that nocebos can create symptoms and illness from nothing, in particul...
1 CitationsSource
#1Christopher J. Beedie (UKC: University of Kent)H-Index: 18
#2Fabrizio Benedetti (UNITO: University of Turin)H-Index: 61
Last. Bart RoelandsH-Index: 26
view all 6 authors...
AbstractPlacebo and nocebo effects are a factor in sports performance. However, the majority of published studies in sport science are descriptive and speculative regarding mechanisms. It is theref...
3 CitationsSource
#1Natalia Egorova (Harvard University)H-Index: 13
#2Fabrizio Benedetti (UNITO: University of Turin)H-Index: 61
Last. Jian Kong (Harvard University)H-Index: 45
view all 4 authors...
BACKGROUND: In experimental placebo and nocebo studies, neutral control treatments are often administered for comparison with active treatments, but are of little interest, as, on average, they result in little change. Yet, when considered at an individual level, they fluctuate between baseline and subsequent measurements and may reveal important information about participants' placebo/nocebo responding tendencies. METHODS: In a paradigm involving application of creams paired with positive, nega...
#1Michael T. Lam (Columbia University)H-Index: 2
#1Michael T. Lam (Columbia University)H-Index: 1
Last. Marco TartagliaH-Index: 39
view all 60 authors...
Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common pathophysiologies. HLH is difficult to diagnose and can be part of inflammatory syndromes. Here, we identify a novel hematological/autoinflammatory condition (NOCARH syndrome) in four unrelated patients with superimposable features, including neonatal-onset cytopenia with dys...
5 CitationsSource
1 CitationsSource
#1Fabrizio Benedetti (UNITO: University of Turin)H-Index: 61
#2Alessandro Piedimonte (UNITO: University of Turin)H-Index: 13
Abstract The placebo effect, once considered only a nuisance in clinical research, is today a target of scientific inquiry that allows us understand how words, rituals and, more in general, the whole psychosocial context around the patient, affect the response to a treatment and the course of a disease. Today we are in a good position to study all these complex psychological factors by using a physiological and neuroscientific approach that uses modern neurobiological tools to probe different br...
1 CitationsSource
#1Vivian Saper (Stanford University)H-Index: 1
#2Guangbo Chen (Stanford University)
Last. Elizabeth D. Mellins (Stanford University)H-Index: 41
view all 72 authors...
Objective To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). Methods In a multicentre retrospective study, 61 cases were investigated using physician-reported clinical information and centralised analyses of radiological, pathological and genetic data. Results LD was associated with distinctive features, including acute erythematous clubbing and a high frequency of anaphylactic reac...
4 CitationsSource
#2Yvan JamillouxH-Index: 15
Last. Fabrizio BenedettiH-Index: 61
view all 9 authors...
Systemic juvenile idiopathic arthritis and adult-onset Still’s disease are rare autoinflammatory disorders with common features, supporting the recognition of these being one disease—Still’s disease—with different ages of onset. Anakinra was recently approved by the European Medicines Agency for Still’s disease. In this review we discuss the reasoning for considering Still’s disease as one disease and present anakinra efficacy and safety based on the available literature. The analysis of 27 stud...
2 CitationsSource
#1Marco Gattorno (Istituto Giannina Gaslini)H-Index: 42
#2Michael HoferH-Index: 29
Last. Nicolino Ruperto (Istituto Giannina Gaslini)H-Index: 62
view all 43 authors...
Background Different diagnostic and classification criteria are available for hereditary recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD) and cryopyrin-associated periodic syndromes (CAPS)—and for the non-hereditary, periodic fever, aphthosis, pharyngitis and adenitis (PFAPA). We aimed to develop and validate new evidence-based classification criteria for HRF/PFAPA. Methods St...
9 CitationsSource