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Bo Ekstrand
Aarhus University
20Publications
10H-index
303Citations
Publications 20
Newest
#1Martin Krøyer Rasmussen (University of Montpellier)H-Index: 15
#2Patrick BalaguerH-Index: 49
Last.Sabine Gerbal-Chaloin (University of Montpellier)H-Index: 26
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Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells. The liver has a high metabolic capacity for skatole and is the first organ encountered by the absorbed skatole; however, the effect of skatole in the liv...
#1Bo EkstrandH-Index: 10
Last.Galia Zamaratskaia (SLU: Swedish University of Agricultural Sciences)H-Index: 25
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We investigated gender-related differences in the ability of selected flavonoids and phenolic compounds to modify porcine hepatic CYP450-dependent activity. Using pools of microsomes from male and female pigs, the inhibition of the CYP families 1A, 2A, 2E1, and 3A was determined. The specific CYP activities were measured in the presence of the following selected compounds: rutin, myricetin, quercetin, isorhamnetin, p-coumaric acid, gallic acid, and caffeic acid. We determined that myricetin and ...
#1Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
#2Galia ZamaratskaiaH-Index: 25
Last.Bo Ekstrand (AU: Aarhus University)H-Index: 10
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Abstract Due to limited availability of human liver tissue for the study of cytochrome P450 (CYP450), porcine liver tissue has been suggested as an alternative source to prepare microsomes and hepatocytes. The porcine liver is made by four different lobes. The present study investigated the expression and activity of specific CYP450 isoforms in the four lobes, with the purpose to examine if one lobe of the porcine liver resembles the human more than others. Samples from the four major lobes were...
#1Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
#2Christina Lindgaard Klausen (AU: Aarhus University)H-Index: 1
Last.Bo Ekstrand (AU: Aarhus University)H-Index: 10
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Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the expression of hepatic CYP mRNA (1A2, 2A19, 2C33, 2D25, 2E1 and 3A29), using primary porcine hepatocytes. Of the tested secondary plant metabolites, artemisinin, scoparone, lactucin and esculetin all induced increased expression of specific CYPs, w...
#1Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
#2Bo Ekstrand (AU: Aarhus University)H-Index: 10
Abstract In pigs the endogenously produced compound androstenone is metabolised in the liver in two steps by 3β-hydroxysteroid dehydrogenase (3β-HSD) and sulphotransferase 2A1 (SULT2A1). The present study investigated the effect of selected sex-steroids (0.01–1 μM androstenone, testosterone and estradiol), skatole (1–100 μM) and secondary plant metabolites (1–100 μM) on the expression of 3β-HSD and SULT2A1 mRNA. Additionally the effect of a global methanolic extract of dried chicory root was inv...
#1Bent Borg Jensen (AU: Aarhus University)H-Index: 47
#2Anne Braad Kudahl (AU: Aarhus University)H-Index: 8
Last.Karin Hjelholt Jensen (AU: Aarhus University)H-Index: 15
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#2Bo EkstrandH-Index: 10
Last.Galia ZamaratskaiaH-Index: 25
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This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids and xenobiotics is more obscure. Based on currently available literature covering humans,rodents and pigs, this review provides an overview of the present knowledge concerning the regulatory mechanisms for 3β-HSD at all omic levels. The HSD isoenz...
#2Bo EkstrandH-Index: 10
Last.Galia ZamaratskaiaH-Index: 25
view all 3 authors...
This review focuses on the expression and regulation of 3β-hydroxysteroid dehydrogenase/Δ 5 -Δ 4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids and xenobiotics is more obscure. Based on currently available literature covering humans, rodents and pigs, this review provides an overview of the present knowledge concerning the regulatory mechanisms for 3β-HSD at all omic levels. The HSD is...
#1Martin Krøyer Rasmussen (AU: Aarhus University)H-Index: 15
#2Galia Zamaratskaia (SLU: Swedish University of Agricultural Sciences)H-Index: 25
Last.Bo Ekstrand (AU: Aarhus University)H-Index: 10
view all 4 authors...
Abstract Hepatic cytochrome P450 expression and activity are dependent on many factors, including dietary ingredients. In the present study, we investigated the in vivo and in vitro effect of chicory root on hepatic CYP3A and 2C in male pigs. Chicory feeding increased the expression of CYP3A29 mRNA but not CYP2C33. Correspondingly, CYP3A activity was increased by chicory feeding, while CYP2C activity was not affected. Additionally, the in vitro effect of chicory extract on the CYP3A activity was...
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