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Gail A. Robertson
University of Wisconsin-Madison
GatinghERGBiochemistryPotassium channelBiology
72Publications
26H-index
4,481Citations
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Publications 72
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#1Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
#2João H. Morais-Cabral (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 5
Last. João H. Morais-Cabral (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 16
view all 2 authors...
Abstract The hERG ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than 20 years ago. In this Perspectives we look at what makes hERG intriguing and vexingly unique. By probing recent high-resolution structures in the context of functional and biochemical data, we attempt to summarize new insights into hERG-specific function and articulate important unanswered questions. X-ray crystallography and cryo-EM have revealed features not previ...
1 CitationsSource
#1Catherine A Eichel (UW: University of Wisconsin-Madison)H-Index: 1
#1Catherine A. Eichel (UW: University of Wisconsin-Madison)H-Index: 4
Last. Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
view all 7 authors...
Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding INa and IKr channels (SCN5A and hERG, respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single molecule fluorescence localization approaches, we find that roughly...
6 CitationsSource
#1Catherine A. Eichel (UW: University of Wisconsin-Madison)H-Index: 4
#1Catherine A Eichel (UW: University of Wisconsin-Madison)H-Index: 1
Last. Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
view all 7 authors...
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#1Catherine A Eichel (UW: University of Wisconsin-Madison)H-Index: 1
#1Catherine A. Eichel (UW: University of Wisconsin-Madison)H-Index: 4
Last. Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
view all 7 authors...
ABSTRACT Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding INa and IKr channels (SCN5A and hERG, respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single-molecule fluorescence localization approaches, we find tha...
Source
#1Bernard AttaliH-Index: 4
#1Bernard Attali (TAU: Tel Aviv University)H-Index: 27
Last. Xiaoliang WangH-Index: 1
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The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely ref...
1 CitationsSource
#1Artur F. Castro-Rodrigues (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 1
#2Yaxian Zhao (UW: University of Wisconsin-Madison)H-Index: 1
Last. João H. Morais-Cabral (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 5
view all 7 authors...
Abstract The Drosophila EAG (dEAG) potassium channel is the founding member of the superfamily of KNCH channels, which are involved in cardiac repolarization, neuronal excitability and cellular proliferation. In flies, dEAG is involved in regulation of neuron firing and assembles with CaMKII to form a complex implicated in memory formation. We have characterized the interaction between the kinase domain of CaMKII and a 53-residue fragment of the dEAG channel that includes a canonical CaMKII reco...
1 CitationsSource
#1David K. Jones (UW: University of Wisconsin-Madison)H-Index: 8
#2Ashley C. Johnson (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
view all 11 authors...
ABSTRACT Reduced levels of the cardiac human (h)ERG ion channel protein and the corresponding repolarizing current I Kr can cause arrhythmia and sudden cardiac death, but the underlying cellular mechanisms controlling hERG surface expression are not well understood. Here, we identified TRIOBP-1, an F-actin-binding protein previously associated with actin polymerization, as a putative hERG-interacting protein in a yeast-two hybrid screen of a cardiac library. We corroborated this interaction by p...
3 CitationsSource
#1David K. JonesH-Index: 8
#2Carol A. HarleyH-Index: 3
Last. Gail A. RobertsonH-Index: 26
view all 5 authors...
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