Guangming Lu
Nanjing University
RadiologyPathologyNeuroscienceResting state fMRIMedicine
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Publications 421
#1Han Zhang (NU: Nanjing University)
#2Yun Fei Wang (NU: Nanjing University)H-Index: 4
Last. Long Jiang Zhang (NU: Nanjing University)H-Index: 23
view all 9 authors...
Abstract Background FK506 binding protein 5 (FKBP5) rs1360780 polymorphism has been identified as a molecular genetic marker associated with the dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis. The impact of FKBP5 rs1360780 on the large-scale brain network connectivity in healthy adults is still unknown. Methods 479 healthy volunteers (age: 20-80years) completed MRI scans, neuropsychological assessments and blood analysis.All subjects were divided into CC, CT and TT genotypes. Withi...
#1Yifei Weng (NU: Nanjing University)H-Index: 3
#2Sara Lariviere (Montreal Neurological Institute and Hospital)H-Index: 6
Last. B.T. Thomas Yeo (NUS: National University of Singapore)H-Index: 26
view all 13 authors...
Thalamo-cortical pathology plays key roles in both generalized and focal epilepsies, but there is little work directly comparing these syndromes at the level of whole-brain mechanisms. Using multimodal imaging, connectomics, and computational simulations, we examined thalamo-cortical and cortico-cortical signatures and underlying microcircuits in 96 genetic generalized (GE) and 107 temporal lobe epilepsy (TLE) patients, along with 65 healthy controls. Structural and functional network profiling ...
1 CitationsSource
#1Rongfeng Qi (Southern Medical University)
#2Wei Chen (Southern Medical University)
Last. Song Luo (NU: Nanjing University)H-Index: 12
view all 15 authors...
Objective: The coronavirus disease 2019 (COVID-19) - a novel and highly infectious pneumonia - has now spread across China and beyond for over four months. However, its psychological impact on patients is unclear. We aim to examine the prevalence and associated risk factors for psychological morbidities and fatigue in patients with confirmed COVID-19 infection. Methods: Amidst the disease outbreak, 41 out of 105 COVID-19 patients in a local designated hospital in China were successfully assessed...
#1Rongfeng QiH-Index: 18
#2Yifeng LuoH-Index: 2
Last. Zhihong CaoH-Index: 2
view all 12 authors...
#1Chaoli XuH-Index: 2
Last. Bin YangH-Index: 1
view all 8 authors...
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length (70 nm), excellent photothermal conversion ability, and a high DSF loading content (23.2%), and the loaded DSFs show glutathione-, acid-, and laser-responsive release properties. The Au-DSF integrates show significantly enhanced cellular uptake efficiency in breast cance...
#1Kai Yan Xiang (NU: Nanjing University)
#2Zi Yue ZuH-Index: 1
Last. Long Jiang ZhangH-Index: 23
view all 4 authors...
The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has spread rapidly throughout China and other countries, and has been characterized as a pandemic. With the strict prevention and control measures implemented by the Chinese government, the spread of the epidemic in China has come under preliminary control by the end of February, 2020, whereas the situation of some countries outside China is not optimistic and raises great public concern. In fighting COVID-19, radiologic examinations pl...
#1Guo-Zhong Chen (Nanjing Medical University)
#2Mengjie Lu (NU: Nanjing University)
Last. Xiu Li Li
view all 13 authors...
OBJECTIVES: To build models based on conventional logistic regression (LR) and machine learning (ML) algorithms combining clinical, morphological, and hemodynamic information to predict individual rupture status of unruptured intracranial aneurysms (UIAs), afterwards tested in internal and external validation datasets. METHODS: Patients with intracranial aneurysms diagnosed by computed tomography angiography and confirmed by invasive cerebral angiograph or clipping surgery were included. The pre...
#1L Wang (NU: Nanjing University)
Last. Guangming Lu (NU: Nanjing University)H-Index: 46
view all 12 authors...
Objective: To compare the radiation dose and image quality of noncontrast chest CT and detection of ground-glass opacity pulmonary nodules (GGN) in domestic 128-slice spiral CT with the other CT scanners from three main stream manufacturers. Methods: From May 8, 2018 to October 31, 2018, noncontrast chest CT images from Neusoft 128-slice CT (75 males, 25 females, (42+/-16) years), dual-source 64-slice CT (53 males, 47 females, (50+/-16) years) and dual-source 128-slice CT scanners(69 males, 31 f...
#1Li Juan Zheng (NU: Nanjing University)H-Index: 5
#2Li Lin (NU: Nanjing University)H-Index: 1
Last. Guangming Lu (NU: Nanjing University)H-Index: 46
view all 12 authors...
Patients with end-stage renal disease (ESRD) are notably accompanied by cognitive disorder and anxiety or depressive symptom. We aimed to explore the linkages of the amygdala-based MR parameters, cognitive and mood performance, systematic inflammation and gut microbiota in ESRD. This prospective study enrolled 28 ESRD patients (13 males and 15 females, mean age of 43.9 +/- 13.8 years) and 19 age- and sex-matched healthy control (HC) (12 males and 7 females, mean age of 44.1 +/- 10.0 years). All ...
#1Zhao Shi (NU: Nanjing University)
Last. Wen Da Xu
view all 18 authors...
Intracranial aneurysm is a common life-threatening disease. CTA is recommended as a standard diagnosis tool, while the interpretation is time-consuming and challenging. We presented a novel deep-learning-based framework trained on 1,177 DSA verified bone-removal CTA cases. The framework had excellent tolerance to the influence of occult cases of CTA-negative but DSA-positive aneurysms, image quality, and manufacturers. Simulated real-world studies were conducted in consecutive internal and exter...