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Mark J. Adams
University of Edinburgh
159Publications
24H-index
2,072Citations
Publications 159
Newest
#1Aleix Arnau-Soler (Edin.: University of Edinburgh)H-Index: 3
#2E. Macdonald-Dunlop (Edin.: University of Edinburgh)H-Index: 1
Last.Keith Milburn (Dund.: University of Dundee)H-Index: 3
view all 6 authors...
Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in U...
5 CitationsSource
#1Darina Czamara (MPG: Max Planck Society)H-Index: 4
#2Gökcen Eraslan (TUM: Technische Universität München)H-Index: 4
Last.Elisabeth B. Binder (MPG: Max Planck Society)H-Index: 75
view all 229 authors...
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
1 CitationsSource
#1Weihua Meng (Dund.: University of Dundee)H-Index: 11
#2Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
Last.Blair H. Smith (Dund.: University of Dundee)H-Index: 57
view all 12 authors...
Knee pain is one of the most common musculoskeletal complaints that brings people to medical attention. Approximately 50% of individuals over the age of 50 report an experience of knee pain within the past 12 months. We sought to identify the genetic variants associated with knee pain in 171,516 subjects from the UK Biobank cohort and seek supporting evidence in cohorts from 23andMe, the Osteoarthritis Initiative, and the Johnston County Osteoarthritis Project. We identified two loci that reache...
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#1Xueyi Shen (Edin.: University of Edinburgh)H-Index: 7
#2Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
Last.Heather C. Whalley (Edin.: University of Edinburgh)H-Index: 47
view all 6 authors...
Abstract Background Studies of white matter microstructure in depression typically show alterations in individuals with depression, but they are frequently limited by small sample sizes and the absence of longitudinal measures of depressive symptoms. Depressive symptoms are dynamic, however, and understanding the neurobiology of different trajectories could have important clinical implications. Methods We examined associations between current and longitudinal measures of depressive symptoms and ...
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#1Weihua Meng (Dund.: University of Dundee)H-Index: 11
#2Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
Last.Blair H. Smith (Dund.: University of Dundee)H-Index: 57
view all 9 authors...
Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the gene...
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#1Mark J. AdamsH-Index: 24
#2David M. HowardH-Index: 10
Last.Andrew M. McIntoshH-Index: 75
view all 10 authors...
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#1Xueyi ShenH-Index: 7
#2David M. HowardH-Index: 10
Last.Andrew M. McIntoshH-Index: 75
view all 6 authors...
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