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Edward C. Holmes
University of Sydney
VirologyPhylogenetic treeVirusGeneticsBiology
773Publications
117H-index
52.8kCitations
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Publications 753
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#1Katherine Eaton (McMaster University)H-Index: 2
#2Nükhet Varlık (USC: University of South Carolina)
Last. Hendrik N. Poinar (McMaster University)H-Index: 43
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#1Yan-Mei Chen (Fudan University)H-Index: 4
#2Yuanting Zheng (Fudan University)H-Index: 8
Last. Jinwen Feng (Fudan University)
view all 27 authors...
COVID-19 is characterised by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand how host responses contribute to COVID-19 pathophysiology, we used a multi-omics approach to identify molecular markers in peripheral blood and plasma samples that distinguish COVID-19 patients experiencing a range of disease severities. A large number of expressed genes, proteins, metabolites and extracellular RNAs (exRNAs) were identified that ...
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#1Yong-Yi Shen (SCAU: South China Agricultural University)H-Index: 14
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
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SARS-CoV-2 is having severe impact on public health at a global scale. Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. We show that CT scans of virus-positive pangolins reveal bilateral ground-glass opacities in lungs in similar manner to COVID-19 patients. The virus infected multiple organs in pangolins, with the lungs being the major target. Histological expression showed that ACE2 and TMPRSS2 are co-expressed with viral RNA. Transcriptome analys...
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#1Sarah J Campbell (Macquarie University)
#2Wilbur Ashley (Macquarie University)
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
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The Red fox (Vulpes vulpes) has established large populations in Australia9s urban and rural areas since its introduction following European settlement. Foxes9 cryptic and highly adaptable nature allows them to invade cities and live among humans while remaining largely unnoticed. Urban living and access to anthropogenic food resources also influences fox ecology. Urban foxes grow larger, live at higher densities and are more social than their rural counterparts. These ecological changes in urba...
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#1Jiaxin Ling (Uppsala University)H-Index: 5
Last. John H.-O. Pettersson (Uppsala University)H-Index: 12
view all 7 authors...
During an ongoing virome metagenomics project we identified hepatitis C virus (HCV) in a pool of recently blood-fed common bed bug (Cimex lectularius) nymphs sampled from domestic residences in Eur...
2 CitationsSource
#1Justine Charon (USYD: University of Sydney)H-Index: 5
#2Vanessa R. Marcelino (USYD: University of Sydney)H-Index: 10
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
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Our knowledge of the diversity and evolution of the virosphere will likely increase dramatically with the study of microbial eukaryotes, including the microalgae in few RNA viruses have been documented to date. By combining meta-transcriptomic approaches with sequence and structural-based homology detection, followed by PCR confirmation, we identified 18 novel RNA viruses in two major groups of microbial algae - the chlorophytes and the chlorarachniophytes. Most of the RNA viruses identified in ...
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#1Ayda Susana Ortiz-Baez (USYD: University of Sydney)H-Index: 2
#2John-Sebastian Eden (USYD: University of Sydney)H-Index: 20
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
view all 4 authors...
The discovery of highly divergent RNA viruses is compromised by their limited sequence similarity to known viruses. Evolutionary information obtained from protein structural modelling offers a powerful approach to detect distantly related viruses based on the conservation of tertiary structures in key proteins such as the RNA-dependent RNA polymerase (RdRp). We utilised a template-based approach for protein structure prediction from amino acid sequences to identify distant evolutionary relations...
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: During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic ...
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#1Susana Ortiz (USYD: University of Sydney)
#2John-Sebastian Eden (USYD: University of Sydney)H-Index: 20
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
view all 4 authors...
The discovery of highly divergent RNA viruses is compromised by their limited sequence similarity to known viruses. Evolutionary information obtained from protein structural modelling offers a powerful approach to detect distantly related viruses based on the conservation of tertiary structures in key proteins such as the viral RNA-dependent RNA polymerase (RdRp). We utilised a template-based approach for protein structure prediction from amino acid sequences to identify distant evolutionary rel...
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#1Ashleigh F. Porter (USYD: University of Sydney)H-Index: 2
#2John H.-O. Pettersson (Uppsala University)H-Index: 12
Last. Edward C. Holmes (USYD: University of Sydney)H-Index: 117
view all 10 authors...
The RNA virus family Flaviviridae harbours several important pathogens of humans and other animals, including Zika virus, dengue virus and hepatitis C virus. The Flaviviridae are currently divided into four genera, Hepacivirus, Pegivirus, Pestivirus and Flavivirus, each of which have a diverse host range. Members of the genus Hepacivirus are associated with a diverse array of animal species, including humans and non-human primates, other mammalian species, as well as birds and fish, while the cl...
1 CitationsSource
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