Camillo Ricordi
University of Miami
IsletImmunologyTransplantationDiabetes mellitusMedicine
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Publications 953
#1Aaron A. Stock (UM: University of Miami)
#2Vita Manzoli (UM: University of Miami)H-Index: 6
Last. Alice A. Tomei (UM: University of Miami)H-Index: 12
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Summary The scarcity of donors and need for immunosuppression limit pancreatic islet transplantation to a few patients with labile type 1 diabetes. Transplantation of encapsulated stem cell-derived islets (SC islets) might extend the applicability of islet transplantation to a larger cohort of patients. Transplantation of conformal-coated islets into a confined well-vascularized site allows long-term diabetes reversal in fully MHC-mismatched diabetic mice without immunosuppression. Here, we demo...
#1Le Wang (NKU: Nankai University)
Last. Zhongyang Shen (NKU: Nankai University)
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Abstract Background A physiological hallmark of patients with type 2 diabetes mellitus (T2DM) is β cell dysfunction. Despite adequate treatment, it is an irreversible process that follows disease progression. Therefore, the development of novel therapies that restore β cell function is of utmost importance. Methods This study aims to unveil the mechanistic action of mesenchymal stem cells (MSCs) by investigating its impact on isolated human T2DM islets ex vivo and in vivo. Findings We propose th...
#1Mirza Muhammad Fahd Qadir (UM: University of Miami)H-Index: 2
#2Giacomo Lanzoni (UM: University of Miami)H-Index: 20
Last. Juan Domínguez-Bendala (UM: University of Miami)H-Index: 19
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Abstract Here we review the characteristics of human pancreatic progenitors, from those that give rise to the different lineages of the pancreas during embryonic development to the cells that have been associated with regenerative processes in adulthood. In the first part of this chapter, we dissect the critical steps that dictate the specification of exocrine and endocrine cell types during pancreatic development, with a special focus on the maturation of pancreatic islet endocrine cells. The s...
#1Elina Linetsky (UM: University of Miami)H-Index: 9
#2Camillo Ricordi (UM: University of Miami)H-Index: 83
Abstract Human islet isolation for autotransplantation (IAT) is performed to prevent surgically induced diabetes following near total or total pancreatectomy. The latter is performed to alleviate intractable pain and suffering, and prolong life in patients suffering from chronic pancreatitis. Since 1997, when it was first performed at the University of Minnesota, islet isolation for IAT following pancreatic resection has been demonstrated as the best option to improve pain, alleviate the risk of...
#1Stephanie S. Camhi (UM: University of Miami)
#2David A. Baidal (UM: University of Miami)H-Index: 24
Last. Camillo Ricordi (UM: University of Miami)H-Index: 83
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Abstract The Diabetes Research Institute (DRI) at the University of Miami, Miller School of Medicine has been performing clinical islet transplantation (ITx) for select patients with type-1 diabetes mellitus (T1DM) and hypoglycemia unawareness since 1985. Over these years, the DRI has blossomed into one of the largest independent ITx centers worldwide, spearheading improvements in multiple aspects of islet isolation and transplantation. Our group has also made important strides in the medical ma...
#1Marco Infante (University of Rome Tor Vergata)H-Index: 1
#2Nathalia Padilla (UM: University of Miami)H-Index: 2
Last. Rodolfo Alejandro (UM: University of Miami)H-Index: 48
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Abstract Liver cirrhosis is an increasing global public health burden, representing a relevant cause of morbidity and mortality worldwide. Hepatogenous diabetes (HD) is defined as an acquired condition of impaired glucose regulation due to the loss of liver function caused by cirrhosis, which exacerbates the poor long-term prognosis of cirrhotic patients. Nevertheless, HD has not yet been considered as a distinct clinical entity separated from classical type 2 diabetes mellitus. However, prompt ...
#1David A. Baidal (UM: University of Miami)H-Index: 24
#2Marco Infante (University of Rome Tor Vergata)H-Index: 1
Last. Rodolfo Alejandro (UM: University of Miami)H-Index: 48
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Abstract Islet transplantation (ITx) is a cellular therapy that has demonstrated efficacy in improving glycemic control and abolishing hypoglycemia in patients affected by type 1 diabetes complicated by hypoglycemia unawareness and episodes of severe hypoglycemia. Although the intrahepatic site is the only clinical site that has shown long-term islet allograft engraftment with achievement of insulin independence, it remains far from being an ideal transplantation site. In this chapter, we have d...
#1Marco InfanteH-Index: 2
#2Camillo RicordiH-Index: 83
Last. Rodolfo AlejandroH-Index: 48
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Recurrence of autoimmunity and allograft rejection represent major challenges that impact the success of islet transplantation. Despite the remarkable improvements achieved in immunosuppression strategies after the publication of the Edmonton protocol, long-term data of intra-hepatic islet transplantation show a gradual decline in beta-cell function. Therefore, there is a growing interest in the investigation of novel, safe and effective anti-inflammatory and immunomodulatory strategies able to ...
#1Rosanna SquittiH-Index: 33
#2Valentine NegroukH-Index: 1
Last. Armando J. Mendez (UM: University of Miami)H-Index: 40
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Abstract Background Type 1 diabetes (T1D) is a chronic condition in which the pancreas loses the ability to produce insulin due to an autoimmune destruction of the insulin producing beta cells in the pancreatic islets of Langerhans. Pathophysiological complications related to diabetes include micro and macrovascular disease, nephropathy, and neuropathy that can also be affected by environmental factors such as lifestyle and diet. Objectives The current study aimed to evaluate the serum levels of...
1 CitationsSource
Sirtuins (SIRTs) are seven nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases enzymes (SIRT1–7) that play an important role in maintaining cellular homeostasis. Among those, the most studied are SIRT1 and SIRT3, a nuclear SIRT and a mitochondrial SIRT, respectively, which significantly impact with an increase in mammals’ lifespan by modulating metabolic cellular processes. Particularly, when activated, both SIRT1 and 3 enhance pancreatic β-cells’ insulin release and reduce i...