David J. Sullivan
Johns Hopkins University
Publications 147
#1Kristin E. Poti (Johns Hopkins University)H-Index: 1
#2Amanda E. Balaban (Johns Hopkins University)H-Index: 4
Last.David J. Sullivan (Johns Hopkins University)H-Index: 38
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The Plasmodium falciparum histidine-rich protein II (PfHRP2) is a common biomarker used in malaria rapid diagnostic tests (RDTs), but can persist in the blood for up to 40 days following curative treatment. The persistence of PfHRP2 presents a false positive limitation to diagnostic interpretation. However, the in vivo dynamics and compartmentalization underlying PfHRP2 persistence have not been fully characterized in the plasma and erythrocyte (RBC) fraction of the whole blood. The kinetics and...
1 CitationsSource
The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2). Here, we review the discovery and biology of HRP2, as well as the strengths and weaknesses of HRP2-based diagnosis compared with alternative antigens. We highlight recent studies describing HRP2 deletion in Latin America, Eritrea, and possibly other re...
#1Evan M. Bloch (Johns Hopkins University)H-Index: 13
#2Beatriz Munoz (Johns Hopkins University)H-Index: 69
Last.Sheila K. West (Johns Hopkins University)H-Index: 75
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The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to determine its effect on clinical symptomatic episodes of malaria as a potential mechanism for mortality benefit. A randomized control trial (RCT) was conducted, whereby 30 randomly selected communities in Kilosa District, Tanzania were randomized to receive 6-monthly treatment of children ages ...
#1Meena SrivastavaH-Index: 3
#2Anouk AmzelH-Index: 9
Last.B. Ryan PhelpsH-Index: 9
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#1Hasan Mohammad Al-Amin (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 5
#2Mohammad Abdullah Heel Kafi (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 2
Last.Mohammad Shafiul Alam (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 14
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#1Tingting LiH-Index: 9
#2Jie FengH-Index: 12
Last.Ying ZhangH-Index: 64
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Bartonella henselae can cause various infections in humans, ranging from benign and self-limiting diseases to severe and life-threatening diseases as well as persistent infections that are difficult to treat. To develop more effective treatments for persistent Bartonella infections, in this study, we performed a high-throughput screen of an FDA-approved drug library against stationary phase B. henselae using the SYBR Green I/propidium iodide (PI) viability assay. We identified 110 drug candidate...
1 CitationsSource
#1Dingyin Tao (Johns Hopkins University)H-Index: 16
#2Brent McGill (Johns Hopkins University)H-Index: 1
Last.Rhoel R. Dinglasan (UF: University of Florida)H-Index: 26
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A large proportion of ongoing malaria parasite transmission is attributed to low-density subclinical infections not readily detected by available rapid diagnostic tests (RDTs) or microscopy. Plasmodium falciparum gametocyte carriage is subclinical, but gametocytemic individuals comprise the parasite reservoir that leads to infection of mosquitoes and local transmission. Effective detection and quantification of these carriers can help advance malaria elimination strategies. However, no point-of-...
7 CitationsSource
#1Kiran Thakur (CUMC: Columbia University Medical Center)H-Index: 9
#2Jimmy Vareta (UNIMA: University of Malawi)H-Index: 2
Last.Karl B. Seydel (MSU: Michigan State University)H-Index: 17
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Cerebral malaria (CM) causes a rapidly developing coma, and remains a major contributor to morbidity and mortality in malaria-endemic regions. This study sought to determine the relationship between cerebrospinal fluid (CSF) Plasmodium falciparum histidine rich protein-2 (PfHRP-2) and clinical, laboratory and radiographic features in a cohort of children with retinopathy-positive CM. Patients included in the study were admitted (2009–2013) to the Pediatric Research Ward (Queen Elizabeth Central ...
1 CitationsSource
#1Isabella A. Quakyi (University of Ghana)H-Index: 30
#2George Adjei (University of Ghana)H-Index: 20
Last.Andrew A. Adjei (Worldwide Universities Network)H-Index: 1
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Background This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up.
1 CitationsSource
#1Hongxia Niu (Lanzhou University)H-Index: 10
#2Rebecca Yee (Johns Hopkins University)H-Index: 4
Last.Ying Zhang (Johns Hopkins University)H-Index: 64
view all 10 authors...