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Lorraine A. Nolte
Washington University in St. Louis
34Publications
25H-index
2,875Citations
Publications 34
Newest
#1Polly A. HansenH-Index: 31
#2Lorraine A. NolteH-Index: 25
Last.Jennifer S. McCartneyH-Index: 9
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#1Polly A. HansenH-Index: 31
#2Lorraine A. NolteH-Index: 25
Last.Ian R. W. RitchieH-Index: 8
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#1John P. KirwanH-Index: 4
#2Raj K. KrishnanH-Index: 12
Last.Keith D. BuchananH-Index: 28
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#1Robert C. HicknerH-Index: 38
#2John O. HolloszyH-Index: 112
Last.Edward O. OjukaH-Index: 11
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#2John O. HolloszyH-Index: 112
Last.Helen H. HostH-Index: 10
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You might find this additional info useful...This article cites€25 articles, 17 of which you can access for free at: http://jap.physiology.org/content/82/2/711.full#ref-list-1This article has been cited by€21 other HighWire-hosted articles: http://jap.physiology.org/content/82/2/711#cited-by Updated information and services including high resolution figures, can be found at: http://jap.physiology.org/content/82/2/711.fullAdditional material and information about Journal of Applied Physiology can...
#1Dong-Ho Han (WashU: Washington University in St. Louis)H-Index: 25
#2Lorraine A. Nolte (WashU: Washington University in St. Louis)H-Index: 25
Last.Clay F. Semenkovich (WashU: Washington University in St. Louis)H-Index: 59
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To address the potential role of lipotoxicity and mitochondrial function in insulin resistance, we studied mice with high-level expression of uncoupling protein-1 in skeletal muscle (UCP-H mice). Body weight, body length, and bone mineral density were decreased in UCP-H mice compared with wild-type littermates. Forelimb grip strength and muscle mass were strikingly decreased, whereas muscle triglyceride content was increased fivefold in UCP-H mice. Electron microscopy demonstrated lipid accumula...
45 CitationsSource
#1Keith Baar (WashU: Washington University in St. Louis)H-Index: 42
#2Zheng Song (WashU: Washington University in St. Louis)H-Index: 2
Last.John O. Holloszy (WashU: Washington University in St. Louis)H-Index: 112
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Nuclear respiratory factor 1 (NRF-1) is a transcriptional activator of nuclear genes that encode a range of mitochondrial proteins including cytochrome c, various other respiratory chain subunits, and δ-aminolevulinate synthase. Activation of NRF-1 in fibroblasts has been shown to induce increases in cytochrome c expression and mitochondrial respiratory capacity. To further evaluate the role of NRF-1 in the regulation of mitochondrial biogenesis and respiratory capacity, we generated transgenic ...
87 CitationsSource
#1Lorraine A. NolteH-Index: 25
#2Dong-Ho HanH-Index: 25
Last.John O. HolloszyH-Index: 112
view all 5 authors...
Stimulation of glucose transport by insulin involves tyrosine phosphorylation of the insulin receptor (IR) and IR substrates (IRSs). Peroxovanadates inhibit tyrosine phosphatases, also resulting in tyrosine phosphorylation of the IRSs. Muscle contractions stimulate glucose transport by a mechanism independent of the insulin-signaling pathway. We found that the peroxovanadate compound bis-peroxovanadium,1,10-phenanthrolene [bpV(phen)] stimulates glucose transport to the same extent as the additiv...
18 CitationsSource
#1Keith Baar (WashU: Washington University in St. Louis)H-Index: 42
#2Adam R. Wende (WashU: Washington University in St. Louis)H-Index: 24
Last.John O. Holloszy (WashU: Washington University in St. Louis)H-Index: 112
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Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little is known about the mechanisms underlying these adaptations, new information has accumulated regarding how mitochondrial biogenesis and GLUT4 expression are regulated. This includes the findings that the transcriptional coactivator PGC-1 promotes mitochondrial biogenesis and that NRF-1 and NRF-2 act as transcriptional activators of genes encoding mitochondrial enzymes. ...
767 CitationsSource
#1Carlos Bernal-Mizrachi (WashU: Washington University in St. Louis)H-Index: 22
#2Sherry Weng (WashU: Washington University in St. Louis)H-Index: 8
Last.Clay F. Semenkovich (WashU: Washington University in St. Louis)H-Index: 59
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Insulin resistance is commonly associated with hypertension, a condition that causes vascular disease in people with obesity and type 2 diabetes. The mechanisms linking hypertension and insulin resistance are poorly understood. To determine whether respiratory uncoupling can prevent insulin resistance-related hypertension, we crossed transgenic mice expressing uncoupling protein 1 (UCP1) in skeletal muscle with lethal yellow (A y /a) mice, genetically obese animals known to have elevated blood p...
64 CitationsSource
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