Thorkild I. A. Sørensen
University of Copenhagen
Publications 832
This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7,388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyse...
#1Mette SørensenH-Index: 40
#2Thorkild I. A. Sørensen (UCPH: University of Copenhagen)H-Index: 95
Last.Ole Raaschou-NielsenH-Index: 57
view all 4 authors...
Objectives Transportation noise has been associated with markers of obesity. We aimed to investigate whether road traffic and railway noise were associated with weight gain during and after pregnancy. Methods Among the women participating in the Danish National Birth Cohort, 74 065 reported on weight before and during the pregnancy (gestational week 30) and 52 661 reported on weight before and 18 months after pregnancy. Residential address history from conception to 18 months after pregnancy was...
#1Britt W. Jensen (Frederiksberg Hospital)H-Index: 4
#2Kathrine Damm Meyle (Frederiksberg Hospital)H-Index: 1
Last.Jennifer L. Baker (UCPH: University of Copenhagen)H-Index: 29
view all 5 authors...
Adult obesity increases risks of renal cell carcinoma (RCC). This study investigated if birth weight, child body mass index (BMI) and height are associated with adult RCC. The study included 301,418 children (152,569 boys) from the Copenhagen School Health Records Register born 1930–1985 with measured weights and heights at ages 7 to 13 years. Birth weight was obtained by parental report. BMI and height were transformed to z-scores, and BMI was categorized as normal BMI or overweight. RCC was id...
#1Caitlin G. Howe (SC: University of Southern California)H-Index: 6
#2Bianca Cox (University of Hasselt)H-Index: 21
Last.Carrie V. Breton (SC: University of Southern California)H-Index: 27
view all 38 authors...
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium. RESEARCH DESIGN AND METHODS Seven pregnancy cohorts (3,677 mother-newborn pairs [317 w...
#1Caitlin G. HoweH-Index: 6
#2Bianca CoxH-Index: 21
Last.Anne P. StarlingH-Index: 12
view all 38 authors...
#1M Mendall (Croydon University Hospital)H-Index: 4
#2Camilla Bjørn Jensen (Frederiksberg Hospital)H-Index: 6
Last.Tine Jess (AAU: Aalborg University)H-Index: 30
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Body mass index (BMI) is associated with increased future risk of inflammatory bowel disease(IBD) particularly Crohn’s disease(CD), where associations with high and low BMI have been observed. Most studies are based on adult women. We aimed to explore the impact of BMI in men entering adult life on their long-term risk of developing IBD. A total of 377,957 men born during 1939–1959, with BMI measured at draft boards at mean age 19, were followed from 1977, or time of examination, to end of 2015....
1 CitationsSource
#1Leanne K. KüpersH-Index: 10
#2Claire Monnereau (EUR: Erasmus University Rotterdam)H-Index: 6
Last.Janine F. Felix (EUR: Erasmus University Rotterdam)H-Index: 33
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Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additi...
3 CitationsSource
#1Joris Deelen (MPG: Max Planck Society)H-Index: 33
#2Daniel S. Evans (CPMC: California Pacific Medical Center)H-Index: 21
Last.Joanne M. Murabito (BU: Boston University)H-Index: 75
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Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipopr...
4 CitationsSource
#1John A. Lees (NYU: New York University)H-Index: 11
#2Bart Ferwerda (UvA: University of Amsterdam)H-Index: 17
Last.Beek van de D (UvA: University of Amsterdam)H-Index: 52
view all 40 authors...
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, ide...
2 CitationsSource
#1Tine Jess (SSI: Statens Serum Institut)H-Index: 30
#2Camilla Schmidt Morgen (UCPH: University of Copenhagen)H-Index: 11
Last.Kristine H. Allin (UCPH: University of Copenhagen)H-Index: 21
view all 7 authors...
Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based cohort study. We linked 43,365 mother-child dyads from a nationwide cohort of pregnant women and their offspring to the Danish National Prescription Registry. Linear and logistic regre...