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Thorkild I. A. Sørensen
Novo Nordisk Foundation
552Publications
77H-index
24.7kCitations
Publications 552
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#1M Mendall (Croydon University Hospital)H-Index: 4
#2Camilla B. Jensen (Frederiksberg Hospital)H-Index: 4
Last.Tine Jess (AAU: Aalborg University)H-Index: 30
view all 6 authors...
Body mass index (BMI) is associated with increased future risk of inflammatory bowel disease(IBD) particularly Crohn’s disease(CD), where associations with high and low BMI have been observed. Most studies are based on adult women. We aimed to explore the impact of BMI in men entering adult life on their long-term risk of developing IBD. A total of 377,957 men born during 1939–1959, with BMI measured at draft boards at mean age 19, were followed from 1977, or time of examination, to end of 2015....
#1Joris Deelen (MPG: Max Planck Society)H-Index: 29
#2Daniel S. Evans (CPMC: California Pacific Medical Center)H-Index: 22
Last.Gil Atzmon (University of Haifa)H-Index: 44
view all 10 authors...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipopr...
#1Leanne K. KüpersH-Index: 9
#2Claire Monnereau (EUR: Erasmus University Rotterdam)H-Index: 6
Last.Darina Czamara (MPG: Max Planck Society)H-Index: 26
view all 10 authors...
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additi...
#1Tine Jess (SSI: Statens Serum Institut)H-Index: 30
#2Camilla Schmidt Morgen (UCPH: University of Copenhagen)H-Index: 9
Last.Kristine H. Allin (UCPH: University of Copenhagen)H-Index: 19
view all 7 authors...
Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based cohort study. We linked 43,365 mother-child dyads from a nationwide cohort of pregnant women and their offspring to the Danish National Prescription Registry. Linear and logistic regre...
#1Tao Huang (PKU: Peking University)H-Index: 15
#2Tiange Wang (Tulane University)
Last.Yujie Wang (UNC: University of North Carolina at Chapel Hill)
view all 10 authors...
Importance Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleo...
This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7,388 twin brothers born 1939-1959 and examined at the conscript board were followed in Danish nationwide registers (1969-2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyse...
#1Jessica L. PetrickH-Index: 12
#2Britt Wang Jensen (Frederiksberg Hospital)H-Index: 4
Last.Jennifer L. Baker (UCPH: University of Copenhagen)H-Index: 27
view all 5 authors...
#1Lise G. Bjerregaard (Frederiksberg Hospital)H-Index: 5
#2Dorthe Pedersen (UCPH: University of Copenhagen)H-Index: 4
Last.Jennifer L. Baker (UCPH: University of Copenhagen)H-Index: 27
view all 5 authors...
#1Nabila Kazmi (UoB: University of Bristol)H-Index: 3
#2Gemma C. Sharp (UoB: University of Bristol)H-Index: 12
Last.Andrew J Simpkin (UoB: University of Bristol)H-Index: 10
view all 10 authors...
Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [...
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