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Ahmed Esmat
Ain Shams University
39Publications
13H-index
471Citations
Publications 39
Newest
#1Sara Emad El-Agamy (Ain Shams University)H-Index: 1
#2Amal Kamal Abdel-Aziz (Ain Shams University)H-Index: 8
Last.Samar S. Azab (Ain Shams University)H-Index: 10
view all 4 authors...
Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors’ quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ‘’doxorubicin’’, which has been shown to be imp...
1 CitationsSource
#1Aya N. Talaat (Ain Shams University)H-Index: 2
#2Sherif S. Ebada (Ain Shams University)H-Index: 11
Last.Abdel Nasser B. Singab (Ain Shams University)H-Index: 16
view all 6 authors...
Abstract Ethnopharmacological relevance Araucaria bidwillii Hook., the bunya pine, is an evergreen plant belonging to family Araucariaceae. Traditionally, its leaves and oleoresins have been used as herbal remedies to alleviate pain and inflammation. Based upon the frequent adverse effects accompanying synthetic anti-inflammatory drugs, this study will assess the anti-inflammatory activity of both the total methanol extract and the polyphenolic-rich fraction of A. bidwillii leaves. Materials and...
2 CitationsSource
#1Ibrahim A. Shehata (KAU: King Abdulaziz University)H-Index: 5
#2Essam El-harshany (KAU: King Abdulaziz University)
Last.Essam Abdel-Sattar (Cairo University)H-Index: 19
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Abstract Introduction Kleinia odora is a wild plant growing in Saudi Arabia and consumed by both animals and people. The plant is rich in triterpenes that are known for their anti-inflammatory activity. In this study, the major triterpenes from this plant were isolated, identified and assessed for their anti-inflammatory activity. Methods Different chromatographic and spectroscopic techniques were used to isolate and identify the major triterpenes isolated from the aerial parts of K. odora. Anti...
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#1Ashraf B. Abdel-Naim (KAU: King Abdulaziz University)H-Index: 20
#2Thikryat Neamatallah (KAU: King Abdulaziz University)H-Index: 4
Last.Osama M. Ashour (KAU: King Abdulaziz University)H-Index: 10
view all 7 authors...
Benign prostatic hyperplasia (BPH) is a common disorder in the male population. 2-Methoxyestradiol (2ME) is an end metabolite of estrogens with pleiotropic pharmacological properties. This study aimed to explore the potential ameliorative effects of 2ME against testosterone-induced BPH in rats. 2-Methoxyestradiol (50 and 100 mg/kg, dissolved in DMSO) prevented the rise in prostatic index and weight in comparison to testosterone-alone-treated animals for 2 weeks. Histological examination indicate...
Source
#1Sara Emad El-Agamy (Ain Shams University)H-Index: 1
#2Amal Kamal Abdel-Aziz (Ain Shams University)H-Index: 8
Last.Samar S. Azab (Ain Shams University)H-Index: 10
view all 5 authors...
Chemobrain refers to a common sequelae experienced by 15–80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, most probably via cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory, and antiapoptotic activities. Therefore, the aim...
15 CitationsSource
#1Ahmed SekkienH-Index: 1
#2Noha SwilamH-Index: 4
Last.Abdel Nasser B. SingabH-Index: 16
view all 7 authors...
Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae), an indigenous plant to the Middle East region, is well-known as a medicinal plant for treating many human ailments. The current study aimed at exploring the polyphenol profile of the alcohol soluble fraction of aqueous T. nilotica extract, assessing its in vivo antifibrotic activity and the possible underlying mechanism, to unravel the impact of quantitative difference of sulphated polyphenols content on the antifibrotic activity of T. nilotca gro...
2 CitationsSource
#1Alaliaa M. Sallam (Ain Shams University)H-Index: 4
#2Ahmed Esmat (Ain Shams University)H-Index: 13
Last.Ashraf B. Abdel-Naim (Ain Shams University)H-Index: 20
view all 3 authors...
4 CitationsSource
#1Sabrin R.M. Ibrahim (Taibah University)H-Index: 20
#2Hossam M. Abdallah (Cairo University)H-Index: 14
Last.Gamal A. Mohamed (Al-Azhar University)H-Index: 20
view all 5 authors...
Abstract The three new metabolites: thiotagetin B (2) [(Z)-1″-([2,2′-bithiophen]-5-yl)-8″-chloro-6″,11″-dimethylundeca-6″,10″-dien-2″-yn-9″-one], tagetannin A (9) [3,4-bis-(galloyl-3,5-dimethyl ether)-(α/β)- d -glucopyranose], and tagetannin B (10) [2,3-bis-(galloyl-3,5-dimethyl ether)-(α/β)- d -glucopyranose], along with ecliptal (5-formyl-α-terthiophene) (1), 5-(4-hydroxybut-1-ynyl)-2,2′-bithiophene (3), scopoletin (4), p-hydroxybenzoic acid (5), protocatechuic acid methyl ester (6), gallic ac...
5 CitationsSource
#1Mansour Sobeh (Heidelberg University)H-Index: 11
#2Fadia S. Youssef (Ain Shams University)H-Index: 10
Last.Michael Wink (Heidelberg University)H-Index: 69
view all 8 authors...
Abstract Oxidative stress plays a crucial role in the development of several liver diseases. Many natural polyphenols can attenuate oxidative stress and liver injury. In this study, a phytochemical profiling of a methanol extract from leaves of Syzygium samarangense revealed 92 compounds belonging to flavonoids, phenolic acids, condensed tannins, and ellagitannins. The S. samarangense extract exhibited a noticeable antioxidant activity with an EC50 of 5.80 μg/mL measured by DPPH scavenging capac...
11 CitationsSource
#1Mansour Sobeh (Heidelberg University)H-Index: 11
#2Ahmed Esmat (Ain Shams University)H-Index: 13
Last.Michael Wink (Heidelberg University)H-Index: 69
view all 8 authors...
Abstract HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decreased the intracellular ROS level and HSP-16.2 expression. In a rat model against acute CCl4 ...
12 CitationsSource
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