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Jinshui Fan
Johns Hopkins University
42Publications
22H-index
1,956Citations
Publications 42
Newest
#1Meher Preethi Boorgula (University of Colorado Denver)H-Index: 9
#2Margaret A. Taub (Johns Hopkins University)H-Index: 18
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 21 authors...
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH−, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+...
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#1Maria Libera Ascierto (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 18
#2Alvin Makohon-Moore (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 12
Last.Suzanne L. Topalian (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 82
view all 21 authors...
Purpose: To explore factors associated with response and resistance to anti–PD-1 therapy, we analyzed multiple disease sites at autopsy in a patient with widely metastatic melanoma who had a heterogeneous response. Materials and Methods: Twenty-six melanoma specimens (four premortem, 22 postmortem) were subjected to whole exome sequencing. Candidate immunologic markers and gene expression were assessed in 10 cutaneous metastases showing response or progression during therapy. Results: The melano...
22 CitationsSource
#1Maria Libera Ascierto (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 18
#2Tracee L. McMiller (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
Last.Suzanne L. Topalian (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 82
view all 15 authors...
Pretreatment tumor PD-L1 expression has been shown to correlate with response to anti–PD-1/PD-L1 therapies. Yet, most patients with PD-L1+ tumors do not respond to treatment. The current study was undertaken to investigate mechanisms underlying the failure of PD-1–targeted therapies in patients with advanced renal cell carcinoma (RCC) whose tumors express PD-L1. Formalin-fixed, paraffin-embedded pretreatment tumor biopsies expressing PD-L1 were derived from 13 RCC patients. RNA was isolated from...
35 CitationsSource
#1Janis M. Taube (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
#2Geoffrey D. Young (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
Last.Suzanne L. Topalian (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 82
view all 13 authors...
Purpose: Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response. We previously found that IFNG (interferon-gamma) was overexpressed by tumor-infiltrating lymphocytes in PD-L1+ versus PD-L1(−) melanomas, creating adaptive immune resistance by promoting PD-L1 display. This study was undertaken to identify additional factors in the PD-L1+ melanoma...
103 CitationsSource
#1Xinmei Zhao (Southern Medical University)H-Index: 1
#2Jinshui Fan (Johns Hopkins University)H-Index: 22
Last.Chris Cheadle (Johns Hopkins University)H-Index: 30
view all 12 authors...
Ulcerative colitis (UC) is a chronic, relapsing and debilitating idiopathic inflammation, with variable and complex pathophysiologies. Our objective was to elucidate patterns of gene expression underlying the progression of UC disease. Single endoscopic pinch FFPE biopsies (n = 41) were sampled at both active and inactive stages at the same site in individual UC patients and compared with each other and with non-inflammatory bowel disease healthy controls. Gene expression results were validated ...
3 CitationsSource
#1Sunita Sharma (Harvard University)H-Index: 20
#2Xiaobo Zhou (Harvard University)H-Index: 44
Last.Benjamin A. Raby (Harvard University)H-Index: 53
view all 33 authors...
Background Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing. Objective We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4 + lymphocytes for association with asthma. Methods eSNPs were tes...
36 CitationsSource
#1Xinmei ZhaoH-Index: 1
#2Aimin LiH-Index: 1
Last.Chris CheadleH-Index: 30
view all 9 authors...
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#1Geoffrey D. Young (Johns Hopkins University)H-Index: 3
#2Tracee L. McMiller (Johns Hopkins University)H-Index: 5
Last.Janis M. Taube (Johns Hopkins University)H-Index: 41
view all 11 authors...
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Blockade of the immunosuppressive PD-1/PD-L1 pathway has shown promising clinical results in patients with treatment-refractory solid tumors including melanoma. PD-L1, a protein displayed by many tumors, ligates the PD-1 co-inhibitory receptor on activated T cells. We previously found that IFN-γ, a potent inducer of PD-L1, was expressed by TILs in PD-L1(+) but not PD-L1(-) melanomas, creating an immunosuppres...
3 CitationsSource
May 1, 2012 in ATS (American Thoracic Society International Conference)
#1Chris Cheadle (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 30
#2Alan E. Berger (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
Last.Kathleen C. Barnes (Johns Hopkins University)H-Index: 59
view all 16 authors...
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May 1, 2012 in ATS (American Thoracic Society International Conference)
#1Li Gao (Johns Hopkins University)H-Index: 21
#2C. Cheadle (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
Last.Paul M. Hassoun (Johns Hopkins University)H-Index: 52
view all 11 authors...
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