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Caroline S. Fox
National Institutes of Health
Publications 705
Published on Feb 1, 2019in The Lancet Diabetes & Endocrinology 19.31
Josef Coresh122
Estimated H-index: 122
(Johns Hopkins University),
Hiddo J. Lambers Heerspink32
Estimated H-index: 32
(University Medical Center Groningen)
+ 134 AuthorsHarold I. Feldman65
Estimated H-index: 65
(University of Pennsylvania)
Summary Background Change in albuminuria as a surrogate endpoint for progression of chronic kidney disease is strongly supported by biological plausibility, but empirical evidence to support its validity in epidemiological studies is lacking. We aimed to assess the consistency of the association between change in albuminuria and risk of end-stage kidney disease in a large individual participant-level meta-analysis of observational studies. Methods In this meta-analysis, we collected individual-l...
3 Citations Source Cite
Published on Jan 1, 2019in Obesity 4.04
Isabelle Schoppa (National Institutes of Health), Asya Lyass27
Estimated H-index: 27
(Boston University)
+ 6 AuthorsMichael M. Mendelson11
Estimated H-index: 11
(Boston Children's Hospital)
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Published on Jan 1, 2018
Alexander Teumer57
Estimated H-index: 57
Layal Chaker16
Estimated H-index: 16
+ 125 AuthorsMasato Akiyama6
Estimated H-index: 6
Published on Jun 1, 2018in Nature 41.58
Benjamin Sun3
Estimated H-index: 3
(University of Cambridge),
Joseph C. Maranville3
Estimated H-index: 3
+ 30 AuthorsPraveen Surendran14
Estimated H-index: 14
(University of Cambridge)
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study. We identify 1,927 genetic associations with 1,478 proteins, a fourfold increase on existing knowledge, including trans associations for 1,104 proteins. To...
12 Citations Source Cite
Published on Jun 19, 2018in Journal of the American Heart Association 4.45
Michael L. Chuang22
Estimated H-index: 22
(National Institutes of Health),
Philimon Gona51
Estimated H-index: 51
(University of Massachusetts Boston)
+ 5 AuthorsChristopher J. O'Donnell104
Estimated H-index: 104
(Harvard University)
Background We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community‐dwelling adults. Methods and Results A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the cen...
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Published on Jan 1, 2018in Circulation-cardiovascular Imaging 6.22
Shih-Jen Hwang38
Estimated H-index: 38
Oyere Onuma4
Estimated H-index: 4
+ 5 AuthorsChristopher J. O’Donnell59
Estimated H-index: 59
Background—Ideal cardiovascular health (CVH) is associated with a lower risk of cardiovascular disease and freedom from coronary artery calcium (CAC). Prospective data on the association between maintenance of optimal CVH and the progression of subclinical coronary atherosclerosis are limited. We assessed the influence of unfavorable versus favorable CVH on the incidence of CAC progression. Methods and Results—The study population consisted of 1119 FHS (Framingham Heart Study) participants who a...
2 Citations Source Cite
Published on Sep 19, 2018in International Journal of Obesity 5.16
Lan Wang1
Estimated H-index: 1
(Boston University),
Jeremiah Perez3
Estimated H-index: 3
(Boston University)
+ 7 AuthorsChing-Ti Liu28
Estimated H-index: 28
(Boston University)
Indices of body fat distribution are heritable, but few genetic signals have been reported from genome-wide association studies (GWAS) of computed tomography (CT) imaging measurements of body fat distribution. We aimed to identify genes associated with adiposity traits and the key drivers that are central to adipose regulatory networks. We analyzed gene transcript expression data in blood from participants in the Framingham Heart Study, a large community-based cohort (n up to 4303), as well as i...
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Published on Dec 1, 2018in Diabetic Medicine 3.13
Caroline S. Fox119
Estimated H-index: 119
(Northampton General Hospital),
A. Kilvert2
Estimated H-index: 2
(Northampton General Hospital)
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Adrienne Tin18
Estimated H-index: 18
(Johns Hopkins University),
Yong Li5
Estimated H-index: 5
(University of Freiburg)
+ 32 AuthorsAurélien Macé7
Estimated H-index: 7
(University of Lausanne)
Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on serum urate. Here we report large-scale whole-exome sequencing association studies of serum urate and kidney function among ≤19,517 European ancestry and African-American individuals. We identify aggregate associations of low-frequency damaging variants in the urate transporters SLC22A12 (URAT1; p = 1.3 × 10−56) and SLC2A9 (p = 4.5 × 10−7)...
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