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Yun Ju Sung
Washington University in St. Louis
57Publications
18H-index
4,167Citations
Publications 57
Newest
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 237 authors...
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
#1Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
#2Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 1
Last.Susan RedlineH-Index: 111
view all 148 authors...
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To provide new insights in the biology of sleep-associated adverse lipid profile, we conducted multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interacti...
#1Seyedeh M. Zekavat (Yale University)H-Index: 13
#2Sanni Ruotsalainen (UH: University of Helsinki)H-Index: 4
Last.Sebastian Zoellner (UM: University of Michigan)H-Index: 3
view all 343 authors...
Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry to discover and interpret both single-nucleotide variants and copy number (CN) variation associated with Lp(a). We observe that genetic determinants betwe...
Background: Dichotomization using the lower quartile as cutoff is commonly used for harmonizing heterogeneous physical activity (PA) measures across studies. However, this may create misclassification and hinder discovery of new loci. Objectives: This study aimed to evaluate the performance of selecting individuals from the extremes of the exposure (SIEE) as an alternative approach to reduce such misclassification. Method: For systolic and diastolic blood pressure in the Framingham Heart Study, ...
#1Changwei LiH-Index: 14
#2Jiang HeH-Index: 103
Last.Tanika N. KellyH-Index: 32
view all 11 authors...
Background— Gene–environmental interaction analysis can identify novel genetic factors for blood pressure (BP). We performed genome-wide analyses to identify genomic loci that interact with potassium to influence BP using single-marker (1 and 2 df joint tests) and gene-based tests among Chinese participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). Methods and Results— Among 1876 GenSalt participants, the average of 3 urine samples was used to estimate potassium ex...
#1Anne E. Justice (UNC: University of North Carolina at Chapel Hill)H-Index: 22
#2Thomas W. Winkler (University of Regensburg)H-Index: 25
Last.L. Adrienne Cupples (BU: Boston University)H-Index: 137
view all 317 authors...
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with conv...
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