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Yun Ju Sung
Washington University in St. Louis
Genome-wide association studyGeneticsBlood pressureLocus (genetics)Biology
57Publications
18H-index
4,167Citations
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Publications 63
Newest
#1Heming Wang (Brigham and Women's Hospital)H-Index: 10
#2Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
Last. Hugues Aschard (Harvard University)H-Index: 21
view all 125 authors...
Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups using 1 degree of freedom (1df) interaction a...
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#1Hanfei Xu (BU: Boston University)H-Index: 3
#2Karen Schwander (WashU: Washington University in St. Louis)H-Index: 15
Last. Oyomoare Osazuwa-Peters (Duke University)
view all 18 authors...
Recent studies consider lifestyle risk score (LRS), an aggregation of multiple lifestyle exposures, in identifying association of gene-lifestyle interaction with disease traits. However, not all cohorts have data on all lifestyle factors, leading to increased heterogeneity in the environmental exposure in collaborative meta-analyses. We compared and evaluated four approaches (Naive, Safe, Complete and Moderator Approaches) to handle the missingness in LRS-stratified meta-analyses under various s...
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#1Kenneth Westerman (Harvard University)H-Index: 3
#2Duy T. Pham (University of Texas Health Science Center at Houston)
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 10 authors...
Gene-environment interaction (GEI) studies are a general framework that can be used to identify genetic variants that modify environmental, physiological, lifestyle, or treatment effects, as well as those contributing to age, sex, racial or ethnic disparities on complex traits. Moreover, genetic association studies accounting for GEIs can enhance our understanding of the genetic architecture of complex diseases by allowing for heterogeneous genetic effects. However, commonly used statistical sof...
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#1Xinyu Wang (University of Texas Health Science Center at Houston)
#2Elise Lim (BU: Boston University)H-Index: 3
Last. Han Chen (University of Texas Health Science Center at Houston)H-Index: 21
view all 9 authors...
Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene-environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate limiting for large biobank-scale sequencing studies with correlated samples. We propose efficient Mixed-model Association tests for GEne-Environment interactions (MAGEE), for testing GEI between an aggregate variant set and environment...
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#1Oyomoare L. Osazuwa-Peters (WashU: Washington University in St. Louis)H-Index: 4
#2R. J. Waken (WashU: Washington University in St. Louis)H-Index: 2
Last. Chengjie Xiong (WashU: Washington University in St. Louis)H-Index: 3
view all 12 authors...
Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene-multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity) on BP. U...
1 CitationsSource
#1L. de las Fuentes (WashU: Washington University in St. Louis)H-Index: 1
#1L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last. Eric A. Whitsel (UNC: University of North Carolina at Chapel Hill)H-Index: 31
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Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individ...
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#1Priyadarshini Kachroo (Brigham and Women's Hospital)H-Index: 4
#2Julian Hecker (Harvard University)H-Index: 2
Last. Sebastian ZoellnerH-Index: 3
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ABSTRACT Background Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based ‘Genetic Epidemiology of Asthma in Costa Rica’ study. Asthma affection ...
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#1Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
#2Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 1
Last. Susan Redline (Brigham and Women's Hospital)H-Index: 111
view all 148 authors...
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint ana...
4 CitationsSource
#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last. Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
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#1Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 14
#2Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 1
Last. Susan RedlineH-Index: 111
view all 148 authors...
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To provide new insights in the biology of sleep-associated adverse lipid profile, we conducted multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interacti...
1 CitationsSource
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