Ma'en Obeidat
University of British Columbia
Publications 104
#1Yilan Sun (ZJU: Zhejiang University)H-Index: 1
#2Stephen Milne (UBC: University of British Columbia)H-Index: 2
Last.Don D. Sin (UBC: University of British Columbia)H-Index: 67
view all 8 authors...
Background There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protective effect – the so-called “obesity paradox”. We aimed to determine the relationship between BMI and the rate of FEV1 decline in data from published clinical trials in COPD.
#1A. Tam (St. Paul's Hospital)H-Index: 1
#2Michael R. Hughes (UBC: University of British Columbia)H-Index: 22
Last.Don D. Sin (St. Paul's Hospital)H-Index: 67
view all 14 authors...
Genome-wide association studies have linked gene variants of the receptor patched homolog 1 (PTCH1) with chronic obstructive pulmonary disease (COPD). However, its biological role in the disease is unclear. Our objective was to determine the expression pattern and biological role of PTCH1 in the lungs of patients with COPD. Airway epithelial-specific PTCH1 protein expression and epithelial morphology were assessed in lung tissues of control and COPD patients. PTCH1 mRNA expression was measured i...
2 CitationsSource
#1H. Takiguchi (UBC: University of British Columbia)H-Index: 1
#2Virginia Chen (UBC: University of British Columbia)H-Index: 8
Last.Don D. Sin (UBC: University of British Columbia)H-Index: 67
view all 8 authors...
Background Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obstructive pulmonary disease (COPD) and its relationship to 1-year mortality following an acute exacerbation of COPD (AECOPD).
#1Ma'en ObeidatH-Index: 20
#2Alen FaizH-Index: 8
Last.Don D. SinH-Index: 67
view all 16 authors...
#1Maarten van den Berge (UMCG: University Medical Center Groningen)H-Index: 29
#2Corry-Anke Brandsma (UMCG: University Medical Center Groningen)H-Index: 19
Last.Dirkje S. Postma (UMCG: University Medical Center Groningen)H-Index: 109
view all 16 authors...
Sex strongly affects the gene expression profile in lung tissue, and overall reflects the activity of different biological pathways that probably play a role in the susceptibility to develop COPD with smoking
#1Nick Shrine (University of Leicester)H-Index: 16
#2Anna L. Guyatt (University of Leicester)H-Index: 3
Last.Louise V. Wain (NIHR: National Institute for Health Research)H-Index: 35
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#1Nick ShrineH-Index: 16
#2Anna L. GuyattH-Index: 3
Last.Maarten van den BergeH-Index: 29
view all 50 authors...
#1Richard J. Allen (University of Leicester)H-Index: 5
#2Beatriz Guillen-Guio (ULL: University of La Laguna)H-Index: 2
Last.Louise V. Wain (NIHR: National Institute for Health Research)H-Index: 35
view all 60 authors...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. The mechanisms by which this arises are poorly understood and it is likely that multiple pathways are involved. The strongest genetic association with IPF is a variant in the promoter of MUC5B where each copy of the risk allele confers a five-fold risk of disease. However, genome-wide association studies h...
1 CitationsSource
#1Linda Kachuri (UCSF: University of California, San Francisco)H-Index: 9
#2Mattias Johansson (IARC: International Agency for Research on Cancer)H-Index: 37
Last.Rayjean J. Hung (U of T: University of Toronto)H-Index: 46
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Impaired lung function is an indicator of obstructive pulmonary disease and may be a consequence of cigarette smoking, making it challenging to disentangle its role in lung cancer etiology. We investigated the shared genetic basis of pulmonary dysfunction and lung cancer susceptibility using genome-wide data from the UK Biobank (>370,000 individuals) and the International Lung Cancer Consortium (29,266 cases, 56,450 controls). We observed strong genetic correlations between lung cancer and reduc...
#1Ma'en Obeidat (UBC: University of British Columbia)H-Index: 20
#2Mohsen Sadatsafavi (UBC: University of British Columbia)H-Index: 26
Last.Don D. Sin (UBC: University of British Columbia)H-Index: 67
view all 3 authors...
1 CitationsSource