Letizia Mattii
University of Pisa
Publications 102
#1Manuela CabiatiH-Index: 15
Last.Silvia Del Ry (Sant'Anna School of Advanced Studies)
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Abstract Chronological age is considered one of the major risk factors for cardiovascular disease and mortality. The study aimed to evaluate the transcriptional levels of the natriuretic peptides (NP), endothelin (ET)-1, adrenomedullin (ADM), their receptors and long non-coding (Lnc) RNA MIAT, MALAT-1, CARMEN and XIST in rat cardiac tissue as cardiovascular biomarkers of aging. Three groups of male Wistar rats were studied: A (n = 6; young), B (n = 13; adult), C (n = 10; old). Total RNA was extr...
#1Antonella Cecchettini (UniPi: University of Pisa)H-Index: 13
#2Francesco Finamore (National Research Council)
Last.Chiara Baldini (UniPi: University of Pisa)H-Index: 27
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Background This proof of concept study was aimed at characterizing novel salivary biomarkers specific for different subsets in primary Sjogren’s syndrome (pSS) in order to improve patients’ profiling.
#1Susanna Grassi (UNISI: University of Siena)H-Index: 6
#2Sara Palumbo (UniPi: University of Pisa)H-Index: 11
Last.Sara Galimberti (UniPi: University of Pisa)H-Index: 25
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Notwithstanding the introduction of Tyrosine Kinase Inhibitors (TKIs) revolutionized the outcome of Chronic Myeloid Leukemia (CML), one third of patients still suspends treatment for failure response. Recent research demonstrated that several BCR/ABL1-independent mechanisms can sustain resistance, but the relationship between these mechanisms and the outcome has not yet been fully understood. This study was designed to evaluate in a “real-life” setting if a change of expression of several genes ...
#1M. CabiatiH-Index: 7
Last.S. Del RyH-Index: 26
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#1Stefano Fogli (UniPi: University of Pisa)H-Index: 19
#2Tommaso Neri (UniPi: University of Pisa)H-Index: 11
Last.Armando Rossello (UniPi: University of Pisa)H-Index: 24
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Abstract Background The role of monocyte/macrophage-derived microparticles (MPs) in the pathophysiology of cancer and chronic inflammatory diseases has been reported; nevertheless, the mechanism underlying microparticles release is currently unclear. The aim of the current study was to investigate whether matrix metalloproteinase (MMP) inhibitors could prevent MP shedding from stimulated human monocyte/macrophage. Methods Microparticles were obtained by isolated peripheral blood mononuclear cell...
#1M. CabiatiH-Index: 7
Last.S. Del RyH-Index: 26
view all 7 authors...
#1Letizia Mattii (UniPi: University of Pisa)H-Index: 17
#2C. Pardini (UniPi: University of Pisa)H-Index: 8
Last.Francesca Vaglini (UniPi: University of Pisa)H-Index: 16
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Abstract Mesencephalic cell cultures are a good model to study the vulnerability of dopaminergic neurons and reproduce, in vitro, experimental models of Parkinson’s disease. Rotenone associated as an environmental neurotoxin related to PD, is able to provoke dopaminergic neuron degeneration by inhibiting complex I of the mitochondrial respiratory chain and by inducing accumulation of α-synuclein. Recently, rotenone has been described to activate RhoA, a GTPase protein. In the present study we ev...
#1Agostina Grillone (IIT: Istituto Italiano di Tecnologia)H-Index: 4
#2Matteo Battaglini (IIT: Istituto Italiano di Tecnologia)H-Index: 4
Last.Gianni Ciofani (IIT: Istituto Italiano di Tecnologia)H-Index: 34
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4 CitationsSource
#1Sara Galimberti (UniPi: University of Pisa)H-Index: 25
#2Susanna Grassi (UNISI: University of Siena)H-Index: 6
Last.Letizia Mattii (UniPi: University of Pisa)H-Index: 17
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The Polycomb gene BMI1 expression exerts a negative predictive impact on several hematological malignancies, such as acute and chronic myeloid leukemia (CML), myelofibrosis, and follicular lymphoma. As already demonstrated in CML, BMI1 is responsible for the resistance to the tyrosine kinase inhibitors (TKIs) in a BCR-ABL1-independent way. Even if, it is unknown where BMI1 in CML is expressed (in progenitors or more mature cells). We decided, therefore, to evaluate if and where the BMI1 protein ...
15 CitationsSource
#1Stefania Moscato (UniPi: University of Pisa)H-Index: 18
#2M. CabiatiH-Index: 7
Last.Letizia Mattii (UniPi: University of Pisa)H-Index: 17
view all 11 authors...
Connexins are a family of membrane-spanning proteins named according to their molecular weight. They are known to form membrane channels mediating cell-cell communication, which play an essential role in the propagation of electrical activity in the heart. Cx26 has been described in a number of tissues but not in the heart, and its mutations are frequently associated with deafness and skin diseases. The aim of this study was to assess the possible Cx26 expression in heart tissues of different ma...
2 CitationsSource