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Xiaodong Yan
University of California, San Diego
Icosahedral symmetryVirologyCapsidCrystallographyBiology
25Publications
10H-index
720Citations
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Publications 26
Newest
#1Qingbing Zheng (Ha Tai: Xiamen University)H-Index: 11
#2Jie Jiang (Ha Tai: Xiamen University)H-Index: 2
Last. Ningshao Xia (Ha Tai: Xiamen University)H-Index: 40
view all 22 authors...
In adaptive immunity, organisms produce neutralizing antibodies (nAbs) to eliminate invading pathogens. Here, we explored whether viral neutralization could be attained through the physical disruption of a virus upon nAb binding. We report the neutralization mechanism of a potent nAb 8C11 against the hepatitis E virus (HEV), a nonenveloped positive-sense single-stranded RNA virus associated with abundant acute hepatitis. The 8C11 binding flanks the protrusion spike of the HEV viruslike particles...
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#1Daniel B. HaackH-Index: 1
#2Xiaodong YanH-Index: 10
Last. Navtej ToorH-Index: 12
view all 7 authors...
Source
#1Daniel B. HaackH-Index: 1
#2Xiaodong YanH-Index: 10
Last. Navtej ToorH-Index: 12
view all 7 authors...
Source
#1Daniel B. Haack (UCSD: University of California, San Diego)H-Index: 1
#2Xiaodong Yan (UCSD: University of California, San Diego)H-Index: 10
Last. Navtej Toor (UCSD: University of California, San Diego)H-Index: 12
view all 7 authors...
Summary Group II introns are a class of retroelements that invade DNA through a copy-and-paste mechanism known as retrotransposition. Their coordinated activities occur within a complex that includes a maturase protein, which promotes splicing through an unknown mechanism. The mechanism of splice site exchange within the RNA active site during catalysis also remains unclear. We determined two cryo-EM structures at 3.6-A resolution of a group II intron reverse splicing into DNA. These structures ...
1 CitationsSource
#1Zhihai Li (Ha Tai: Xiamen University)H-Index: 4
#2Shuo Song (Ha Tai: Xiamen University)H-Index: 3
Last. Ningshao Xia (Ha Tai: Xiamen University)H-Index: 40
view all 21 authors...
Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structural similarity of L1 surface loops within a group of phylogenetically close HPV types, we design a triple-type chimera of HPV33/58/52 using loop swapping. The chimeric VLPs elicit neutralization titers...
1 CitationsSource
#1Zhiqing ZhangH-Index: 2
#2Maozhou HeH-Index: 4
Last. Ningshao XiaH-Index: 40
view all 11 authors...
Source
#1Rui Zhu (Ha Tai: Xiamen University)H-Index: 4
#2Longfa Xu (Ha Tai: Xiamen University)H-Index: 8
Last. Ningshao Xia (Ha Tai: Xiamen University)H-Index: 40
view all 20 authors...
Coxsackievirus A10 (CVA10) recently emerged as a major pathogen of hand, foot, and mouth disease and herpangina in children worldwide, and lack of a vaccine or a cure against CVA10 infections has made therapeutic antibody identification a public health priority. By targeting a local isolate, CVA10-FJ-01, we obtained a potent antibody, 2G8, against all three capsid forms of CVA10. We show that 2G8 exhibited both 100% preventive and 100% therapeutic efficacy against CVA10 infection in mice. Compar...
2 CitationsSource
#1Longfa Xu (Ha Tai: Xiamen University)H-Index: 8
#2Qingbing Zheng (Ha Tai: Xiamen University)H-Index: 11
Last. Ningshao Xia (Ha Tai: Xiamen University)H-Index: 40
view all 23 authors...
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identic...
12 CitationsSource
#1Zhihai LiH-Index: 4
#2Daning WangH-Index: 5
Last. Ningshao XiaH-Index: 40
view all 17 authors...
Author(s): Li, Z; Wang, D; Gu, Y; Song, S; He, M; Shi, J; Liu, X; Wei, S; Li, J; Yu, H; Zheng, Q; Yan, X; Baker, TS; Zhang, J; McLellan, JS; Li, S; Xia, N
4 CitationsSource
#1Zhihai Li (Ha Tai: Xiamen University)H-Index: 4
#2Xiaodong Yan (PKU: Peking University)H-Index: 10
Last. Ningshao Xia (Ha Tai: Xiamen University)H-Index: 40
view all 18 authors...
Summary Cervical cancer is the second most prevalent malignant tumor among women worldwide. High-risk human papillomaviruses (HPVs) are believed to be the major causative pathogens of mucosal epithelial cancers including cervical cancer. The HPV capsid is made up of 360 copies of major (L1) and 72 copies of minor (L2) capsid proteins. To date, limited high-resolution structural information about the HPV capsid has hindered attempts to understand details concerning the mechanisms by which HPV ass...
10 CitationsSource
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