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Shu Ting Yang
National Cheng Kung University
6Publications
5H-index
66Citations
Publications 6
Newest
#1C-J Yen (NCKU: National Cheng Kung University)H-Index: 24
#2Shu Ting Yang (NCKU: National Cheng Kung University)H-Index: 5
Last.Liang-Yi HungH-Index: 15
view all 13 authors...
Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcinoma (HCC); however, the interaction between CPAP and HBx in HBV-HCC remains unclear. The mRNA expression of CPAP and HBx was analyzed by quantitative-PCR (Q-PCR). NF-κB transcriptional activi...
Source
#1Yu Wen Yeh (NDMC: National Defense Medical Center)H-Index: 1
#2Ching Chia Cheng (NDMC: National Defense Medical Center)H-Index: 1
Last.Jen Liang SuH-Index: 24
view all 12 authors...
// Yu-Wen Yeh 1, 2 , Ching-Chia Cheng 3, 4 , Shu-Ting Yang 4 , Chi-Feng Tseng 4 , Ting-Yu Chang 4 , Sin-Ying Tsai 5 , Earl Fu 6 , Chien-Ping Chiang 7 , Li-Chuan Liao 8 , Pei-Wen Tsai 9 , Yung-Luen Yu 5, 10, 11 , Jen-Liang Su 4, 5, 10, 11 1 Division of Dermatology, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei 10581, Taiwan 2 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan 3 Graduate Institute of Life Sciences, ...
8 CitationsSource
#1Hsin An Chen (TMU: Taipei Medical University)H-Index: 8
#2Tsang Chih Kuo (NTU: National Taiwan University)H-Index: 9
Last.Jen Liang SuH-Index: 24
view all 9 authors...
20 CitationsSource
#1Ya Ping Chen (NCKU: National Cheng Kung University)H-Index: 8
#2Hui Ju Lin (NCKU: National Cheng Kung University)H-Index: 1
Last.Tsai-Yun Chen (NCKU: National Cheng Kung University)H-Index: 17
view all 14 authors...
Overexpression of Aurora kinases is largely observed in many cancers, including hematologic malignancies. In this study, we investigated the effects and molecular mechanisms of Aurora kinase inhibitors in acute lymphoblastic leukemia (ALL). Western blot analysis showed that both Aurora-A and Aurora-B are overexpressed in ALL cell lines and primary ALL cells. Both VE-465 and VX-680 effectively inhibited Aurora kinase activities in nine ALL cell lines, which exhibited different susceptibilities to...
6 CitationsSource
#1Shu Ting Yang (NCKU: National Cheng Kung University)H-Index: 5
#2C-J Yen (NCKU: National Cheng Kung University)H-Index: 24
Last.Liang-Yi HungH-Index: 15
view all 14 authors...
Background & Aims Constitutive activation of NF-κB is an important event involved in chronic inflammation in hepatocellular carcinoma (HCC). CPAP, which plays important roles in centrosomal functions, was previously identified as the transcriptional co-activator of NF-κB. However, the molecular mechanism is unclear. The goal of this study was to investigate the role of CPAP in activating the NF-κB pathway in HCC. Methods SK-Hep1, HuH7, HepG2, HepG2X, Hep3B, and Hep3BX cells with CPAP overexpress...
12 CitationsSource
#1Jen Hui Tsou (NCKU: National Cheng Kung University)H-Index: 9
#2Kung-Chao Chang (NCKU: National Cheng Kung University)H-Index: 22
Last.Liang-Yi Hung (NCKU: National Cheng Kung University)H-Index: 15
view all 14 authors...
Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is i...
20 CitationsSource
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