Daan van Rooij
Radboud University Nijmegen
PsychiatryPsychologyNeuroscienceAttention deficit hyperactivity disorderBiology
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Publications 42
#1Paul M. Thompson (SC: University of Southern California)H-Index: 141
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Willem Bruin (UvA: University of Amsterdam)H-Index: 1
view all 170 authors...
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in ...
6 CitationsSource
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
#1Christienne G. Damatac (Radboud University Nijmegen)H-Index: 3
#2Marcel P. Zwiers (Radboud University Nijmegen)H-Index: 38
Last. Emma Sprooten (Radboud University Nijmegen)H-Index: 27
view all 13 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter microstructure, measured by diffusion-weighted imaging (DWI) and quantified by fractional anisotropy (FA). In the largest DWI analysis of ADHD to date, we systematically investigated if FA is associated with: current and lifetime diagnosis, categorical diagnosis and continuo...
#1Odile A. van den Heuvel (VU: VU University Amsterdam)H-Index: 11
#2Premika S.W. Boedhoe (VU: VU University Amsterdam)H-Index: 6
Last. Joseph O'Neill (Semel Institute for Neuroscience and Human Behavior)H-Index: 29
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Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as ac...
#1Ting Li (Radboud University Nijmegen)
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 12
Last. Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 7 authors...
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder in children and adults. Neuroanatomic heterogeneity limits our understanding of the etiology of ADHD. This study aimed to parse neuroanatomic heterogeneity of ADHD, and to determine whether subgroups could be discerned in patients based on subcortical volumes. Methods: Using the dataset from the ENIGMA-ADHD Working Group, we applied exploratory factor analysis (EFA) to subcortical volumes of 99...
#1Merel Postema (MPG: Max Planck Society)H-Index: 1
#2Daan van RooijH-Index: 12
Last. Clyde Francks (MPG: Max Planck Society)H-Index: 42
view all 58 authors...
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface...
4 CitationsSource
#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 12
Last. Jan K. Buitelaar (Radboud University Nijmegen)H-Index: 104
view all 9 authors...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mea...
#1Torbjørn Elvsåshagen (Oslo University Hospital)H-Index: 16
#2Shahram Bahrami (University of Oslo)H-Index: 4
Last. Tobias Kaufmann (Oslo University Hospital)H-Index: 23
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Brainstem regions support critical bodily functions, yet their genetic architectures and involvement in brain disorders remain understudied. Here, we examined volumes of brainstem structures using magnetic resonance imaging in 43,353 individuals. In 27,034 genotyped healthy participants, we identified 16 genetic loci associated with whole brainstem volume and 10, 23, 3, and 9 loci associated with volumes of the midbrain, pons, superior cerebellar peduncle, and medulla oblongata, respectively. Th...
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
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1 CitationsSource
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 289 authors...
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysi...
5 CitationsSource