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Keiko Maekawa
Doshisha Women's College of Liberal Arts
123Publications
25H-index
1,603Citations
Publications 125
Newest
#1Masahiro Tohkin (Nagoya City University)H-Index: 10
#2Yuko SaitoH-Index: 62
Last.Naoki Miyata (Nagoya City University)H-Index: 48
view all 8 authors...
Abstract Recently, genomic biomarkers have been widely used clinically for prediction of the efficacy and safety of pharmacotherapy and diagnosis and prognosis of pathological conditions. Therefore, genomic biomarkers are anticipated to accelerate not only precision medicine for pharmacotherapy but also development of molecularly targeted drugs. Because the design of clinical studies involving biomarkers may differ from conventional clinical study designs, a concept paper focused on clinical stu...
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#1Kosuke SaitoH-Index: 10
#2Hiroaki YagiH-Index: 1
Last.Naoto MinaminoH-Index: 52
view all 16 authors...
Aortic aneurysms are associated with fatal aortic rupture. Current therapeutic approaches are limited to implantation of aortic prostheses and stent-grafts; no effective drugs are available because the pathogenic mechanisms of aortic aneurysms remain unclear. Here, we aimed to elucidate the molecular mechanisms of the initiation and progression of aortic aneurysm by lipidomics. We performed lipidomics analyses of lipids in the aortic media of normal, border, and aneurysm areas from patients with...
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#1Keiko Maekawa (Doshisha Women's College of Liberal Arts)H-Index: 25
#2Masaki Ri (Nagoya City University)H-Index: 17
Last.Shinsuke Iida (Nagoya City University)H-Index: 38
view all 9 authors...
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#1Keiko MaekawaH-Index: 25
#2Motoyasu AdachiH-Index: 13
Last.M.B. ShahH-Index: 11
view all 3 authors...
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#1Keiko MaekawaH-Index: 25
#2Motoyasu AdachiH-Index: 13
Last.M.B. ShahH-Index: 11
view all 3 authors...
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#1Keiko MaekawaH-Index: 25
#2Motoyasu AdachiH-Index: 13
Last.M.B. ShahH-Index: 11
view all 7 authors...
Single-nucleotide polymorphisms in drug-metabolizing cytochrome P450 (CYP) enzymes are important contributors to interindividual differences in drug metabolism leading to adverse drug reactions. Despite their extensive characterization and importance in pharmacogenetics of clinical drugs, the structural basis of CYP polymorphisms has remained scant. Here we report the crystal structures of human CYP2C9 and its polymorphic variants, *3 (I359L) and *30 (A477T), with an antihypertensive drug losart...
10 CitationsSource
#1Keiko MaekawaH-Index: 25
#2Kazuo Okemoto (Nagoya City University)H-Index: 1
Last.Yuko SaitoH-Index: 62
view all 6 authors...
Abstract Lipid metabolites in the blood are expected to be biomarker candidates to reflect disease states and responses to therapeutic drugs. However, their profiles are influenced by subject background, which may lead to confounding results. This study aimed to evaluate whether age and gender affect lipid metabolite levels in the plasma of healthy Japanese adults. Comprehensive lipidomic analysis was performed using liquid chromatography-mass spectrometry for overnight fasted volunteers consist...
1 CitationsSource
#1Yuji Kumagai (Kitasato University)H-Index: 24
#2Ildae Song (Kitasato University)H-Index: 2
Last.Tomoe Fujita (Kitasato University)H-Index: 13
view all 9 authors...
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In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinical toxicity studies of compound X, a candidate compound in drug development, and mitochondrial dysfunction in order to estimate the potential risk of the compound to induce drug-induced liver injury (D...
5 CitationsSource
#1Kosuke SaitoH-Index: 10
#2Masaki IshikawaH-Index: 14
Last.Yuko SaitoH-Index: 62
view all 6 authors...
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