Huaxiao Yang
Stanford University
Induced pluripotent stem cellCardiologyStem cellBiologyCell biology
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Publications 36
#1Soah Lee (Stanford University)H-Index: 5
#2Huaxiao Yang (Stanford University)H-Index: 10
Last. Timon SeegerH-Index: 10
view all 8 authors...
Micropatterning techniques have been widely used in cell biology to study effects of controlling cell shape and size on cell fate determination at single cell resolution. Current state-of-the-art single cell micropatterning techniques involve soft lithography and micro-contact printing, which is a powerful technology, but requires trained engineering skills and certain facility support in microfabrication. These limitations require a more accessible technique. Here, we describe a simple alternat...
#1Hao Chen (CAS: Chinese Academy of Sciences)H-Index: 7
#1Hao Chen (CAS: Chinese Academy of Sciences)H-Index: 11
Last. Hung-Ta Wo (Cardiovascular Institute of the South)
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Stem cell therapy holds high promises in regenerative medicine. The major challenge of clinical translation is to precisely and quantitatively evaluate the in vivo cell distribution, migration, and engraftment, which cannot be easily achieved by current techniques. To address this issue, for the first time, we have developed a single molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1000-1700 nm) for real-time monitoring of in vivo cell behavio...
#1Haodi Wu (Stanford University)H-Index: 20
#2Huaxiao Yang (Stanford University)H-Index: 10
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 13 authors...
5 CitationsSource
#1Jing Shi (Fudan University)H-Index: 3
#2Yumeng Xing (Fudan University)H-Index: 1
Last. J.B. Ge (Fudan University)H-Index: 2
view all 9 authors...
#1Huaxiao Yang (Stanford University)H-Index: 10
#2Xulei Qin (Stanford University)H-Index: 12
Last. Kai Li (Stanford University)H-Index: 37
view all 15 authors...
A major challenge in myocardial infarction (MI)-related heart failure treatment using microRNA is the efficient and sustainable delivery of miRNAs into myocardium to achieve functional improvement through stimulation of intrinsic myocardial restoration. In this study, we established an in vivo delivery system using polymeric nanoparticles to carry miRNA (miNPs) for localized delivery within a shear-thinning injectable hydrogel. The miNPs triggered proliferation of human embryonic stem cell-deriv...
1 CitationsSource
#1Timon Seeger (Stanford University)H-Index: 10
#2Rajani Shrestha (Stanford University)H-Index: 4
Last. Joseph C. Wu (Stanford University)H-Index: 91
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Background: Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in myosin-binding protein C3 (MYBPC3) resulting in a premature termination codon (PTC). The underlying mechanisms of ...
4 CitationsSource
#1Alexa Wnorowski (Cardiovascular Institute of the South)H-Index: 3
#2Huaxiao Yang (Cardiovascular Institute of the South)H-Index: 10
Last. Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 3 authors...
Abstract In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology research by strengthening the relevance of culture-based models while reducing costly animal studies. Although OOC models can incorporate a variety of tissue sources, the most...
3 CitationsSource
#1Haodi Wu (Stanford University)H-Index: 20
#2Huaxiao Yang (Stanford University)H-Index: 10
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 11 authors...
#1Kai LiH-Index: 37
#2Carmel T. ChanH-Index: 12
Last. Heike E. Daldrup-LinkH-Index: 41
view all 9 authors...
1 CitationsSource
#1Xin Zhao (Cardiovascular Institute of the South)H-Index: 4
#2Haodong Chen (Cardiovascular Institute of the South)H-Index: 12
Last. Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 20 authors...
Summary Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown. To examine this, RNU rats received intramyocardial injection of 1 × 10 7 NHP or human iPSC-CMs or the same number of respective fibroblasts or PBS control (n = 9–14/group) at 4 days after 60-min coronary artery occlusion-reperfusion. Cardiac...
6 CitationsSource