John Foley
Indiana University
Publications 44
Last.John FoleyH-Index: 19
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#1Bin Chen (SCUT: South China University of Technology)H-Index: 2
#2Yue Wu (IU: Indiana University Bloomington)H-Index: 2
Last.Feng Guo (IU: Indiana University)H-Index: 28
view all 10 authors...
Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic microenvironment, is appropriate for recapitulating tissue cellular adhesive complexity and revealing a more realistic drug response. However, current 3D culture methods are suffering from low-throughput, poor controllability, intensive-labor, and variation in spheroid size, thus not ready for many high-throughput screening applications including drug discovery and toxicity testing. Herein, we developed a ...
2 CitationsSource
#1A. Filipowicz (IU: Indiana University)
#2H. Wu (University of Cincinnati Academic Health Center)
Last.John Foley (IU: Indiana University)H-Index: 19
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#1Qixuan Wang (UCI: University of California, Irvine)H-Index: 5
#2Ji Won OhH-Index: 7
Last.Maksim V. Plikus (UCI: University of California, Irvine)H-Index: 27
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© Wang et al. The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cy...
13 CitationsSource
#1Hsing Jung Wu (IUPUI: Indiana University – Purdue University Indianapolis)
#2Ji Won Oh (KNU: Kyungpook National University)H-Index: 7
Last.John Foley (IU: Indiana University)H-Index: 19
view all 11 authors...
Maintenance of specialized epidermis requires signals from the underlying mesenchyme; however, the specific pathways involved remain to be identified. By recombining cells from the ventral skin of the K14-PTHrP transgenic mice [which overexpress parathyroid hormone-related protein (PTHrP) in their developing epidermis and mammary glands] with those from wild type, we show that transgenic stroma is sufficient to reprogram wild-type keratinocytes into nipple-like epidermis. To identify candidate n...
#1Kah Tan Allen (IU: Indiana University)H-Index: 3
#2Helen Chin-Sinex (IU: Indiana University)H-Index: 10
Last.Marc S. Mendonca (IU: Indiana University)H-Index: 22
view all 9 authors...
We investigated whether altering Warburg metabolism (aerobic glycolysis) by treatment with the metabolic agent dichloroacetate (DCA) could increase the X-ray-induced cell killing of the radiation-resistant human non-small-cell lung cancer (NSCLC) cell lines A549 and H1299. Treatment with 50 mM DCA decreased lactate production and glucose consumption in both A549 and H1299, clear indications of attenuated aerobic glycolysis. In addition, we found that DCA treatment also slowed cell growth, increa...
13 CitationsSource
#1Sachiko Koyama (IU: Indiana University)H-Index: 4
#2Helena A. Soini (IU: Indiana University Bloomington)H-Index: 16
Last.Milos V. Novotny (IU: Indiana University Bloomington)H-Index: 18
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The current understanding of the activity of mammalian pheromones is that endocrine and behavioural effects are limited to the exposed individuals. Here, we demonstrate that the nasal exposure of female mice to a male murine pheromone stimulates expansion of mammary glands, leading to prolonged nursing of pups. Subsequent behavioural testing of the pups from pheromone-exposed dams exhibited enhanced learning. Sialic acid components in the milk are known to be involved in brain development. We hy...
3 CitationsSource
#1Chih Feng Chen (NCHU: National Chung Hsing University)H-Index: 3
#2John FoleyH-Index: 19
Last.Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 8 authors...
The feather is a complex ectodermal organ with hierarchical branching patterns. It provides functions in endothermy, communication, and flight. Studies of feather growth, cycling, and health are of fundamental importance to avian biology and poultry science. In addition, feathers are an excellent model for morphogenesis studies because of their accessibility, and their distinct patterns can be used to assay the roles of specific molecular pathways. Here we review the progress in aspects of devel...
43 CitationsSource
#1Sachiko Koyama (IU: Indiana University Bloomington)H-Index: 4
#2Helena A. Soini (IU: Indiana University Bloomington)H-Index: 16
Last.Cary Lai (IU: Indiana University Bloomington)H-Index: 1
view all 5 authors...
Enhancement of adult neurogenesis in female mice was previously demonstrated through exposure to soiled bedding from males, although the identity of relevant chemosignals has remained unknown. The farnesenes and SBT (2-sec-butyl-4,5-dihydrothiazole) are male murine pheromones that dominant males secrete at higher levels. Previous studies have shown that they induce oestrus in female mice. We have recently shown that these pheromones strongly increase cell proliferation in the SVZ (subventricular...
4 CitationsSource
#1Guntram Borck (University of Ulm)H-Index: 29
#2Liat de Vries (TAU: Tel Aviv University)H-Index: 14
Last.Lina Basel-VanagaiteH-Index: 32
view all 13 authors...
Athelia is a very rare entity that is defined by the absence of the nipple–areola complex. It can affect either sex and is mostly part of syndromes including other congenital or ectodermal anomalies, such as limb-mammary syndrome, scalp–ear–nipple syndrome, or ectodermal dysplasias. Here, we report on three children from two branches of an extended consanguineous Israeli Arab family, a girl and two boys, who presented with a spectrum of nipple anomalies ranging from unilateral hypothelia to bila...
2 CitationsSource