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António J. Ribeiro
University of Coimbra
NanoparticleChemistryInsulinChitosanChromatography
90Publications
28H-index
3,986Citations
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Publications 91
Newest
#1Ana C. SantosH-Index: 13
Last. Francisco VeigaH-Index: 46
view all 9 authors...
Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of adverse effects. Considering that the development of nanotechnology-based formulations as ha...
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#1Mar Collado-González (UC: University of Coimbra)H-Index: 1
Last. António J. RibeiroH-Index: 28
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Polyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethylene glycol) 4000, poloxamer 188, chitosan, and bovine serum albumin. The nanocomposites were obtained by Ca2+-induced gelation of alginate followed by an electrostatic-interaction process among the polyelectrolytes. Chitosan seemed to be essential for the final size of the nanoco...
1 CitationsSource
#1Joana Sequeira (UC: University of Coimbra)H-Index: 3
#2Irina Pereira (UC: University of Coimbra)H-Index: 3
Last. Ana C. Santos (UC: University of Coimbra)H-Index: 13
view all 5 authors...
Abstract Since their introduction 40 years ago, poly( d,l -lactic-co-glycolic acid) (PLGA) polymers have been used commonly in tissue engineering and drug delivery systems. These polymers are currently a well-known biodegradable, biocompatible Food and Drug Administration (FDA)/European Medicines Agency (EMA) approved material for controlled release applications in industrial research and academia. As a carrier, PLGA improves drugs stability and drugs pharmacokinetics, which is beneficial to R&D...
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#1Ana C. Santos (UC: University of Coimbra)H-Index: 13
#2Joana Sequeira (UC: University of Coimbra)H-Index: 3
Last. Francisco Veiga (UC: University of Coimbra)H-Index: 46
view all 9 authors...
Abstract This paper advances the development of a novel drug nanodelivery solution to the oral administration of resveratrol (RSV), a low soluble drug whose recognized therapeutic applications are circumscribed when administered in the free compound form. Layer-by-Layer (LbL) self-assembly is an emergent nanotechnology proposed to address this concern with means to afford control over key formulation parameters, which are able to ultimately promote an improved pharmacokinetics. LbL self-assembly...
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#1Ana C. Santos (UC: University of Coimbra)H-Index: 13
#2Irina Pereira (UC: University of Coimbra)H-Index: 3
Last. Francisco Veiga (UC: University of Coimbra)H-Index: 46
view all 9 authors...
Abstract Background Resveratrol (RES) is a polyphenol which has attracted great interest in the academic and industrial communities due to its natural origin and potential health benefits. Nevertheless, the administration of RES is restrained by its properties, such as poor water solubility, lack of stability due to light-induced isomerization, as well as auto-oxidation and rapid metabolization. Therefore, recently, nanotechnology, through different approaches, emerged as a potential solution to...
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#1Ana C. Santos (UC: University of Coimbra)H-Index: 13
#2Irina Pereira (UC: University of Coimbra)H-Index: 3
Last. Francisco Veiga (UC: University of Coimbra)H-Index: 46
view all 10 authors...
Abstract Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biological activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnology appeared as a potential strategy to circumvent RES physicochemica...
2 CitationsSource
#1Ana C. SantosH-Index: 13
#2Joana SequeiraH-Index: 3
Last. António J. RibeiroH-Index: 28
view all 5 authors...
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#1A. R. Pinho (UC: University of Coimbra)H-Index: 1
#2Ana Fortuna (UC: University of Coimbra)H-Index: 17
Last. António J. Ribeiro (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 28
view all 8 authors...
Abstract The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, in order to achieve the therapeutic goals, among which ELISA and HPLC arise. ...
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#1Ana C. Santos (UC: University of Coimbra)H-Index: 13
#2Irina Pereira (UC: University of Coimbra)H-Index: 3
Last. Francisco Veiga (UC: University of Coimbra)H-Index: 46
view all 9 authors...
Resveratrol (RSV) is a polyphenol endowed with potential therapeutic effects in chronic diseases, particularly in cancer, the second leading cause of death worldwide in the twenty-first century. The advent of nanotechnology application in the field of drug delivery allows to overcome the constrains associated with the conventional anticancer treatments, in particular chemotherapy, reducing its adverse side effects, off target risks and surpassing cancer multidrug chemoresistance. Moreover, the u...
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#1Ana C. Santos (UC: University of Coimbra)H-Index: 13
#2Francisca Morais (UC: University of Coimbra)H-Index: 1
Last. António J. Ribeiro (UC: University of Coimbra)H-Index: 28
view all 8 authors...
ABSTRACTIntroduction: Nanotechnology is an increasingly widespread area of research for its various applications and advantages. Accordingly, nanotechnology has been the focus of investment in diff...
3 CitationsSource
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