Madhu Dikshit
Central Drug Research Institute
Publications 197
#1Deepika Awasthi (Central Drug Research Institute)H-Index: 6
#2Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
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Abstract Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as well as in the pathophysiology of various inflammatory disease conditions. Two major types of NETosis have been described - NOX-dependent and independent. The present study was undertaken to assess metabolic requirements of NETs formation by using PMA and A23187 as the inducers of NOX-dependent and NOX-independent NETosis respectively. Both these inducers caused an increase in ECAR, lactate dehydr...
#1Ankita Singh (Central Drug Research Institute)H-Index: 7
#2Vishal Singh (Central Drug Research Institute)H-Index: 16
Last.Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 21
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#1Samreen Sadaf (Central Drug Research Institute)
#2Abhishek Singh (Central Drug Research Institute)H-Index: 9
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
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Abstract Recent study from this lab indicated enhanced susceptibility of iNOS KO mice for diet induced obesity (DIO) and systemic insulin resistance (IR) as compared to C57BL/6 (WT) mice. The present study investigates aortic vasoreactivity in high fat diet (HFD) induced insulin resistant iNOS KO mice. WT and iNOS KO mice were fed with 45% HFD/10% LFD for ten weeks. Systemic IR was assessed via measurement of circulating lipids, glucose, and insulin; while phenylephrine (PE)/acetylcholine (ACh) ...
#1Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
#2Samreen Sadaf (Central Drug Research Institute)
Last.Madhu DikshitH-Index: 33
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AbstractRecent report from this lab has shown role of Rac2 in the translocation of inducible nitric oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes (PMNs) following phagocytosis of beads. This study was undertaken to further assess the status and role of tetrahydrobiopterin (BH4), a redox-sensitive cofactor, L-arginine, and the substrate of nitric oxide synthase (NOS) in sustained nitric oxide (˙NO) production in killing of phagocytosed microbes (Escherichia c...
#1Jitendra S. Kanshana (Central Drug Research Institute)H-Index: 3
#2Sanjay C. Rebello (Central Drug Research Institute)H-Index: 1
Last.Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 21
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Abstract Ethnopharmacological relevance Xylocarpus moluccensis (Lamk.) M. Roem of family Meliaceae has triterpenoids rich fruits. Triterpenoids have been known to possess cardioprotection and anti-atherosclerotic activities (Han and Bakovic, 2015; Wu et al., 2009). Standardized fraction of these fruits exhibited anti-dyslipidemic (Srivastava et al., 2015), anti-inflammatory (Ravangpai et al., 2011) and CNS depressant activity (Sarker et al., 2007). However, there is no report in the literature o...