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Madhu Dikshit
Central Drug Research Institute
EndocrinologyChemistryNitric oxideBiochemistryPlatelet
195Publications
34H-index
3,672Citations
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Publications 196
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#1Priya Gupta (Central Drug Research Institute)H-Index: 1
#2Amit Kumar (Central Drug Research Institute)H-Index: 27
Last. Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 22
view all 9 authors...
OBJECTIVE: This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice. METHODS: Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund's adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progression and mechanism were assessed by micro-CT analysis, RT-PCR, flow cytometry assay, myeloperoxidase (MPO) and MTT assay. RESULTS...
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#1Amit Kumar (CSIR: Council of Scientific and Industrial Research)H-Index: 20
#1Amit KumarH-Index: 27
Last. Manoj Kumar BarthwalH-Index: 22
view all 6 authors...
Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in oxidized LDL (Ox-LDL)-induced macrophage foam cell formation and inflammation is unknown and therefore was studied. In recombinant mouse granulocyte-macrophage colony-stimulating factor-differentiated murine bone marrow-derived macrophages, early (1-6 h) Ox-LDL treatment induced PKM2 tyrosine 105 phosphorylation and promotes its nuclear localization. PKM2 regula...
1 CitationsSource
#1Samreen Sadaf (Central Drug Research Institute)H-Index: 1
#2Deepika Awasthi (Central Drug Research Institute)H-Index: 7
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 7 authors...
Abstract Previous studies from this lab and others have demonstrated that nitric oxide (NO) in a concentration dependent manner, modulated neutrophil and leukemic cell survival. Subsequent studies delineated importance of iNOS in neutrophil differentiation and leukemic cell death. On the contrary, role of nNOS in survival of these cells remains least understood. Present study was therefore undertaken to assess and compare the role of iNOS and nNOS in the survival of NOS overexpressing myelocytic...
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#1Deepika Awasthi (Central Drug Research Institute)H-Index: 7
#2Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 6 authors...
Abstract Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as well as in the pathophysiology of various inflammatory disease conditions. Two major types of NETosis have been described - NOX-dependent and independent. The present study was undertaken to assess metabolic requirements of NETs formation by using PMA and A23187 as the inducers of NOX-dependent and NOX-independent NETosis respectively. Both these inducers caused an increase in ECAR, lactate dehydr...
1 CitationsSource
#1Ankita Singh (Central Drug Research Institute)H-Index: 9
#2Vishal Singh (Central Drug Research Institute)H-Index: 16
Last. Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 22
view all 7 authors...
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#1Samreen Sadaf (Central Drug Research Institute)H-Index: 1
#2Abhishek Singh (Central Drug Research Institute)H-Index: 11
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 10 authors...
1 CitationsSource
#1Priya Pathak (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Jitendra S. Kanshana (Central Drug Research Institute)H-Index: 3
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 7 authors...
Abstract Recent study from this lab indicated enhanced susceptibility of iNOS KO mice for diet induced obesity (DIO) and systemic insulin resistance (IR) as compared to C57BL/6 (WT) mice. The present study investigates aortic vasoreactivity in high fat diet (HFD) induced insulin resistant iNOS KO mice. WT and iNOS KO mice were fed with 45% HFD/10% LFD for ten weeks. Systemic IR was assessed via measurement of circulating lipids, glucose, and insulin; while phenylephrine (PE)/acetylcholine (ACh) ...
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#1Abrar Ali Khan (Indian Institute of Technology Madras)H-Index: 3
#2Poovitha Sundar (Indian Institute of Technology Madras)
Last. Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 22
view all 8 authors...
3-Hydroxy-3-methyl glutaryl-coenzyme A reductase (Hmgcr) encoding the rate-limiting enzyme in the cholesterol biosynthesis pathway is a candidate gene for essential hypertension (EH). However, the regulation of Hmgcr in rat models of hypertension (viz. Spontaneously Hypertensive Rats [SHR] and its normotensive control Wistar/Kyoto [WKY] strain) is unknown. Here, we show that Hmgcr transcript and protein levels are diminished in liver tissues of SHR as compared to WKY. Consistently, a number of o...
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#1Sheela Nagarkoti (Central Drug Research Institute)H-Index: 5
#2Samreen Sadaf (Central Drug Research Institute)H-Index: 1
Last. Madhu DikshitH-Index: 34
view all 7 authors...
Recent report from this lab has shown role of Rac2 in the translocation of inducible nitric oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes (PMNs) following phagocytosis of beads. This study was undertaken to further assess the status and role of tetrahydrobiopterin (BH4), a redox-sensitive cofactor, L-arginine, and the substrate of nitric oxide synthase (NOS) in sustained nitric oxide (˙NO) production in killing of phagocytosed microbes (Escherichia coli) by ...
1 CitationsSource
#1Chandra Prakash Pandey (King George's Medical University)H-Index: 1
#2Ankita Misra (Central Drug Research Institute)H-Index: 7
Last. Madhu Dikshit (Central Drug Research Institute)H-Index: 34
view all 8 authors...
Background & objectives: Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT). The present study was undertaken to identify aspirin and clopidogrel non-responsiveness and its association with genetic polymorphism in patients with myocardial infarction (MI). Methods: A total of 207 MI patients who were on DAPT, were included. The DAPT non-responsive...
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