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Zhiyu Li
China Pharmaceutical University
ChemistryApoptosisWogoninBiochemistryBiology
175Publications
24H-index
2,058Citations
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Publications 160
Newest
#1Jie Han (CAS: Chinese Academy of Sciences)H-Index: 4
#2Yucheng Tian (CPU: China Pharmaceutical University)H-Index: 1
Last. LUOCheng (CAS: Chinese Academy of Sciences)
view all 15 authors...
Abstract USP8, one member of deubiquitinating enzymes (DUBs) families, maintains the ubiquitination level of EGFR and regulates the downstream signaling pathways. The deregulation of USP8 has been implicated in many human diseases, especially in cancer. Therefore, USP8 has been identified as a promising target for drug design. Herein, via high throughput screening based on Ubiquitin-rhodamine-110 (Ubiquitin-Rho-110) fluorometric activity assay, we discovered a novel inhibitor DC-U43. By structur...
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#1Pengfei Xu (CPU: China Pharmaceutical University)H-Index: 3
Last. Raoling Ge (Academy of Medical Sciences, United Kingdom)H-Index: 1
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A scalable and practical route to the P2Y2 receptor agonist diquafosol tetrasodium has been described. Diquafosol tetrasodium was obtained via a four-step process starting from commercially availab...
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#1Hongyu Luan (CPU: China Pharmaceutical University)H-Index: 2
#2Pengfei Xu (CPU: China Pharmaceutical University)H-Index: 3
Last. Jinlei Bian (CPU: China Pharmaceutical University)H-Index: 12
view all 5 authors...
Abstract Prostate cancer is the most common carcinoma of the male urinary system in developed countries. Androgen deprivation therapy has been commonly used in the treatment of Prostate cancer for decades, but most patients will inevitably develop into more aggressive castration-resistant prostate cancer. Therefore, novel strategies are urgent to address this resistance mechanism. In this review, we discussed some new strategies for targeting androgen receptors through degradation pathways as po...
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#1Pengfei Xu (CPU: China Pharmaceutical University)H-Index: 3
#2Pei Shen (CPU: China Pharmaceutical University)H-Index: 1
Last. Jubo Wang (CPU: China Pharmaceutical University)H-Index: 6
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Abstract The Janus kinases or JAKs are a family of intracellular tyrosine kinases that play an essential role in the signaling of numerous cytokines that have been implicated in the pathogenesis of autoimmune diseases and myeloproliferative disorders. JAKs are activated upon ligand induced receptor homo- or heterodimerization, which results in the immediate phosphorylation of tyrosine residues and the phosphotyrosines then serve as docking sites for cytoplasmic signal transducer and activator of...
1 CitationsSource
#1Xi Xu (CPU: China Pharmaceutical University)H-Index: 5
#2Qianming Du (Nanjing Medical University)H-Index: 1
Last. Siqi Xue (Nanjing Medical University)
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Abstract Prostate cancer (PC) is the most diagnosed type of malignancy in men and the major frequently cause of cancer-related death worldwide. The androgen receptor (AR) has become a promising drug target for the treatment of PC. Here, we reported the design, optimization and evaluation of pyridine tetrahydroisoquinoline thiohydantoin derivatives with improved activity and safety as potent AR antagonists. The most promising compound 42f exhibited potent inhibitory activity on AR and strongly bl...
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#1Yujie Huang (CPU: China Pharmaceutical University)H-Index: 7
#2Xuwei Luo (CPU: China Pharmaceutical University)H-Index: 2
Last. Na Lu (CPU: China Pharmaceutical University)H-Index: 34
view all 9 authors...
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#1Yucheng Tian (CPU: China Pharmaceutical University)H-Index: 1
#2Jubo Wang (CPU: China Pharmaceutical University)H-Index: 6
Last. Jinlei Bian (CPU: China Pharmaceutical University)H-Index: 12
view all 9 authors...
A microwave-assisted, efficient and rapid Sonogashira reaction was developed for the synthesis of polysubstituted aromatic alkynes. The reaction was environmentally friendly and easy to handle by replacing traditional amine solvents with water. The optimized reaction conditions could obtain the products with high yields, while reducing the dependence on anaerobic reaction conditions with no inert gas protection. The reaction can also achieve milligram level, overcoming the problem of TMSA volati...
1 CitationsSource
#1Yangjie Fu (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhaohui Wang (CAS: Chinese Academy of Sciences)H-Index: 57
Last. Jiang Wang (CAS: Chinese Academy of Sciences)H-Index: 22
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In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(II) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy, and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility, and mechanistic studies were conducted. It offers a direct and efficient way to synthesize pyridone der...
2 CitationsSource
#1Lin Yang (CPU: China Pharmaceutical University)H-Index: 5
#2Zihao He (CPU: China Pharmaceutical University)H-Index: 3
Last. Libin Wei (CPU: China Pharmaceutical University)H-Index: 16
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#1Yongjian Guo (FIU: Florida International University)H-Index: 2
#2Libin Wei (CPU: China Pharmaceutical University)H-Index: 16
Last. Xiaotang Wang (FIU: Florida International University)H-Index: 24
view all 7 authors...
Abstract Energy metabolism plays important roles in the growth and survival of cancer cells. Here, we find a newly synthesized flavonoid named GL-V9, which inhibits glycolysis and induces apoptosis of human breast cancer cell lines, and investigate the underlying mechanism. Results show that hexokinase II (HKII) plays important roles in the anticancer effects of GL-V9. GL-V9 not only downregulates the expression of HKII in MDA-MB-231 and MCF-7 cells, but also induces dissociation of HKII from vo...
2 CitationsSource
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