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Lorenzo Fornaro
University of Pisa
CancerOncologyFOLFOXIRIColorectal cancerMedicine
174Publications
17H-index
1,408Citations
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Publications 181
Newest
#1Massimiliano Salati (University of Modena and Reggio Emilia)H-Index: 6
#2R. Filippi (UNITO: University of Turin)H-Index: 4
Last. Andrea Casadei-Gardini (University of Modena and Reggio Emilia)H-Index: 1
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BACKGROUND: An accurate risk-stratification is key to optimize the benefit-to-risk ratio of palliative treatment in advanced biliary cancer. We aimed at assessing the impact of the prognostic nutritional index (PNI) on survival and treatment response in advanced biliary cancer (ABC) receiving first-line chemotherapy. METHODS: Medical records of ABC treated with standard chemotherapy at the Modena Cancer Centre were retrospectively reviewed for variables deemed of potential interest, including th...
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Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICI) have been proven to be safe and effective in the treatment of highly lethal malignancies, such as non-small cell lung cancer and melanoma. Recent clinical trials also showed promising activity in immune checkpoint inhibitors in pretreated advanced esophageal carcinoma and a potentially significant impact on the outcome of selected patients, inde...
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#1Piermarco Papini (UniPi: University of Pisa)H-Index: 3
#2Silvia RicciH-Index: 29
Last. Gianluca MasiH-Index: 33
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#1Lorenzo FornaroH-Index: 17
#2Caterina VivaldiH-Index: 10
Last. Giuseppe AprileH-Index: 25
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The optimal management of gastric adenocarcinoma (GC) and gastroesophageal junction adenocarcinoma (GEJC) remains a critical challenge for medical oncologists. Indeed, this is a relevant burden since GC still stands fifth among the most common tumors and is the third leading cause of cancer-related death worldwide (1).
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#1Lorenzo FornaroH-Index: 17
#2Francesco Leone (UNITO: University of Turin)H-Index: 20
Last. Francesco MontagnaniH-Index: 8
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ABSTRACT Background FOLFIRINOX is an option for fit patients with metastatic (MPC) and locally advanced unresectable (LAPC) pancreatic cancer. However, no criteria reliably identify patients with better outcome. Patients and Methods We investigated putative prognostic factors among 137 MPC/LAPC patients treated with triplet chemotherapy. Association with 6-month survival status (primary endpoint) was assessed by multivariate logistic regression models. A nomogram predicting the risk of death at ...
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#2Giorgia MarisiH-Index: 9
Last. Mario Scartozzi (University of Cagliari)H-Index: 32
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Abstract Background In two retrospective studies we analyzed endothelial-derived nitric oxide synthase (eNOS) and angiopoietin-2 (ANGPT2) polymorphisms, and patients with eNOS-786CC+TC genotype and ANGPT2rs55633437 GG genotypes had significantly higher median PFS and OS compared to those with other genotypes. On the basis of these preliminary results, our aim was to validate in a prospective study these data in patients with HCC treated with sorafenib (S). Methods The primary outcomes were PFS. ...
1 CitationsSource
#1Irene PecoraH-Index: 1
#2Lorenzo FornaroH-Index: 17
Last. Caterina VivaldiH-Index: 10
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#1Caterina VivaldiH-Index: 10
#2Lorenzo FornaroH-Index: 17
Last. Enrico VasileH-Index: 21
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Early tumor shrinkage (ETS) and depth of response (DoR) predict favorable outcomes in metastatic colorectal cancer. We aim to evaluate their prognostic role in metastatic pancreatic cancer (PC) patients treated with first-line modified-FOLFIRINOX (FOLFOXIRI) or Gemcitabine + Nab-paclitaxel (GemNab). Hence, 138 patients were tested for ETS, defined as a ≥20% reduction in the sum of target lesions’ longest diameters (SLD) after 6–8 weeks from baseline, and DoR, i.e., the maximum percentage shrinka...
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#1Silvia CataneseH-Index: 2
Last. Lorenzo FornaroH-Index: 17
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#1A. Casadei GardiniH-Index: 20
#2Giorgia MarisiH-Index: 9
Last. Mario Scartozzi (University of Cagliari)H-Index: 32
view all 19 authors...
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