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Luca Miele
Sapienza University of Rome
252Publications
30H-index
3,912Citations
Publications 256
Newest
#1Umberto Basile (UCSC: Catholic University of the Sacred Heart)H-Index: 6
#2Mariapaola Marino (UCSC: Catholic University of the Sacred Heart)H-Index: 13
Last.Gian Ludovico Rapaccini (UCSC: Catholic University of the Sacred Heart)H-Index: 31
view all 12 authors...
Abstract Background Infections, autoimmunity and cancer play a role as determinants of etiology in Hepatitis C virus (HCV) related mixed cryoglobulinemia (MC). Several factors of risk have been suggested as markers of pathogenesis and progression of HCV-related MC into B cell Non-Hodgkin's Lymphoma (B-NHL). Here, we evaluated IgG subclass distribution, free light chains (FLCs) and vascular endothelial growth factor (VEGF) as a new combination of biomarkers. Methods We measured IgG1–4 subclasses,...
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#2Alessio AghemoH-Index: 29
Last.Edoardo G. GianniniH-Index: 40
view all 8 authors...
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is expected to become the leading cause of end-stage liver disease worldwide over the next few decades. In fact, NAFLD encompasses different clinical scenarios, from the simple accumulation of fat (steatosis) to steatohepatitis (NASH), NASH-cirrhosis, and cirrhosis complications. In this context, it is fundamental to pursue strategies aimed at both preventing the disease and reducing the progression ...
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#1Serena Pelusi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 13
#2Guido Alessandro Baselli (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 4
Last.Luca Valenti (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 48
view all 22 authors...
Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and 50 controls, and considered 404 healthy individuals from 1000 G. Pathogenic variants were defined according to ClinVar, likely pathogenic as rare variants predicted to alter protein...
4 CitationsSource
#1Nicoletta De Matthaeis (UCSC: Catholic University of the Sacred Heart)H-Index: 4
#2Carmine Di Stasi (UCSC: Catholic University of the Sacred Heart)H-Index: 14
Last.Luca Miele (UCSC: Catholic University of the Sacred Heart)H-Index: 30
view all 6 authors...
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#1Gianluigi Mazzoccoli (Casa Sollievo della Sofferenza)H-Index: 24
#2Luca MieleH-Index: 30
Last.Antonio GriecoH-Index: 29
view all 6 authors...
The biological clock controls at the molecular level several aspects of mammalian physiology, by regulating daily oscillations of crucial biological processes such as nutrient metabolism in the liver. Disruption of the circadian clock circuitry has recently been identified as an independent risk factor for cancer and classified as a potential group 2A carcinogen to humans. Hepatocellular carcinoma (HCC) is the prevailing histological type of primary liver cancer, one of the most important causes...
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#1Quirino LaiH-Index: 17
#2Alessandro VitaleH-Index: 38
Last.Edoardo G. GianniniH-Index: 40
view all 12 authors...
Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor...
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#1Luca MieleH-Index: 30
#2F. R PonzianiH-Index: 2
Last.Antonio GasbarriniH-Index: 72
view all 33 authors...
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#1Paola Dongiovanni (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 39
#2Annalisa Crudele (Boston Children's Hospital)H-Index: 8
Last.Anna Alisi (Boston Children's Hospital)H-Index: 38
view all 13 authors...
Abstract Background and Aim Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in adults and children. Along with obesity, diabetes and insulin resistance, genetic factors strongly impact on NAFLD development and progression. Dysregulated bile acid metabolism and the fibroblast growth factor 19 (FGF19) pathway play a pivotal role in NAFLD pathogenesis. However, it remains to be defined the mechanism through which the FGF19 receptor system is associated with li...
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1 CitationsSource
#1Valerio Nobili (Sapienza University of Rome)H-Index: 51
#2Anna Alisi (Boston Children's Hospital)H-Index: 38
Last.Naim AlkhouriH-Index: 28
view all 6 authors...
Nonalcoholic fatty liver disease (NAFLD) has rapidly become the most common form of chronic liver disease in children and adolescents. Over the past 5 years, developments have revolutionized our understanding of the genetic factors, natural history, diagnostic modalities and therapeutic targets for this disease. New polymorphisms, such as those in PNPLA3, TM6SF2, MBOAT7 and GCKR, have been identified and used to predict the development and severity of NAFLD in both adults and children, and their...
3 CitationsSource
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