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Melissa Laura Fernandez
Queensland University of Technology
11Publications
5H-index
88Citations
Publications 10
Newest
#2Dario StuparH-Index: 3
Last.Zee UptonH-Index: 32
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Significance Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. While some of this research has translated to advancements in wound therapies and implementation of new treatment options, chronic wounds remain a significant challe...
4 Citations
#2Dario StuparH-Index: 3
Last.Zee UptonH-Index: 32
view all 5 authors...
Significance: Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. While some of this research has translated to advancements in wound therapies and implementation of new treatment options, chronic wounds remain a significant chall...
7 CitationsSource
#1Q. Zeng (SUNY: State University of New York System)H-Index: 1
#2L.K. Macri (SUNY: State University of New York System)H-Index: 1
Last.Zee UptonH-Index: 32
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The integration of healing, cell biology, and skin tissue engineering research has been ongoing for nearly one century. In this chapter, we provide a bird’s eye view of skin anatomy and functions, wound healing processes, the challenges and solutions to wound healing. Many techniques and biomaterials have been examined for their potential utility as skin substitutes. Notwithstanding evidence that some strategies have been more successful than others, the ideal skin substitute does not exist. Exi...
Source
#1Srihari Sharma (QUT: Queensland University of Technology)
#2Rajesh Gupta (QUT: Queensland University of Technology)H-Index: 7
Last.Shooter Gary (QUT: Queensland University of Technology)
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Abstract Introduction Diabetes-related ulcers are a common and severe complication of diabetes which is expected to increase in prevalence in line with projected global growth in rates of diabetes. Caring for these chronic wounds imposes a multi-billion dollar burden on the health care systems. These ulcers can prove lethal if untreated or not recognised and can lead to critical health complications. Methods To investigate underlying causes of wound chronicity, proteomic analyses of swab samples...
Source
#1Melissa Laura Fernandez (QUT: Queensland University of Technology)H-Index: 5
#2Zee Upton (QUT: Queensland University of Technology)H-Index: 32
Last.Gary K. Shooter (QUT: Queensland University of Technology)H-Index: 9
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Chronic wounds are an important health problem because they are difficult to heal and treatment is often complicated, lengthy and expensive. For a majority of sufferers the most common outcomes are long-term immobility, infection and prolonged hospitalisation. There is therefore an urgent need for effective therapeutics that will enhance ulcer healing and patient quality of life, and will reduce healthcare costs. Studies in our laboratory have revealed elevated levels of purine catabolites in wo...
9 CitationsSource
#1Daniel BroszczakH-Index: 4
#2Dario StuparH-Index: 3
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Free to read The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughput approach to investigate the altered biochemical state within wound samples collected fr...
6 Citations
#1Melissa Laura Fernandez (QUT: Queensland University of Technology)H-Index: 5
#2Zee Upton (QUT: Queensland University of Technology)H-Index: 32
Last.Gary K. Shooter (QUT: Queensland University of Technology)H-Index: 9
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Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating wi...
28 CitationsSource
Chronic venous leg ulcers are a detrimental health issue plaguing our society, resulting in long term pain, immobility and decreased quality of life for a large proportion of sufferers. The frequency of these chronic wounds has led current research to focus on the wound environment to provide important information regarding the prolonged, fluctuated or static healing patterns of these wounds. Disruption to the normal wound healing process results in release of multiple factors in the wound envir...
1 Citations
Source
#1Melissa Laura Fernandez (QUT: Queensland University of Technology)H-Index: 5
#2James A. Broadbent (QUT: Queensland University of Technology)H-Index: 7
Last.Zee Upton (QUT: Queensland University of Technology)H-Index: 32
view all 5 authors...
Summary Background Chronic venous leg ulcers are a significant cause of pain, immobility and decreased quality of life for patients with these wounds. In view of this, research efforts are focused on multiple factors in the wound environment to obtain information regarding the healing of ulcers. Objectives Chronic wound fluid (CWF), containing a complex mixture of proteins, is an important modulator of the wound environment, and therefore we hypothesized that these proteins may be indicators of ...
34 CitationsSource
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