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Melissa Laura Fernandez
Queensland University of Technology
13Publications
4H-index
75Citations
Publications 13
Newest
Published on Apr 21, 2017in Advances in wound care
L FernandezMelissa1
Estimated H-index: 1
,
StuparDario1
Estimated H-index: 1
+ 2 AuthorsUptonZee1
Estimated H-index: 1
Significance: Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. While some of this research has translated to advancements in wound therapies and implementation of new treatment options, chronic wounds remain a significant chall...
Published on Jan 1, 2017
Q. Zeng1
Estimated H-index: 1
(SUNY: State University of New York System),
L.K. Macri1
Estimated H-index: 1
(SUNY: State University of New York System)
+ 10 AuthorsDario Stupar2
Estimated H-index: 2
The integration of healing, cell biology, and skin tissue engineering research has been ongoing for nearly one century. In this chapter, we provide a bird’s eye view of skin anatomy and functions, wound healing processes, the challenges and solutions to wound healing. Many techniques and biomaterials have been examined for their potential utility as skin substitutes. Notwithstanding evidence that some strategies have been more successful than others, the ideal skin substitute does not exist. Exi...
Srihari Sharma (QUT: Queensland University of Technology), Rajesh Gupta7
Estimated H-index: 7
(QUT: Queensland University of Technology)
+ 4 AuthorsShooter Gary (QUT: Queensland University of Technology)
Abstract Introduction Diabetes-related ulcers are a common and severe complication of diabetes which is expected to increase in prevalence in line with projected global growth in rates of diabetes. Caring for these chronic wounds imposes a multi-billion dollar burden on the health care systems. These ulcers can prove lethal if untreated or not recognised and can lead to critical health complications. Methods To investigate underlying causes of wound chronicity, proteomic analyses of swab samples...
Published on Jan 1, 2013
Melissa Laura Fernandez4
Estimated H-index: 4
,
Zee Upton31
Estimated H-index: 31
,
Gary K. Shooter8
Estimated H-index: 8
Chronic wounds are an important health problem because they are difficult to heal and treatment is often complicated, lengthy and expensive. For a majority of sufferers the most common outcomes are long-term immobility, infection and prolonged hospitalisation. There is therefore an urgent need for effective therapeutics that will enhance ulcer healing and patient quality of life, and will reduce healthcare costs. Studies in our laboratory have revealed elevated levels of purine catabolites in wo...
Published on Jan 1, 2012
Daniel Broszczak4
Estimated H-index: 4
,
Dario Stupar2
Estimated H-index: 2
+ 5 AuthorsMelissa Laura Fernandez4
Estimated H-index: 4
The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughput approach to investigate the altered biochemical state within wound samples collected from various ty...
Published on Apr 1, 2012in International Wound Journal2.38
Melissa Laura Fernandez4
Estimated H-index: 4
(QUT: Queensland University of Technology),
Zee Upton31
Estimated H-index: 31
(QUT: Queensland University of Technology)
+ 2 AuthorsGary K. Shooter8
Estimated H-index: 8
(QUT: Queensland University of Technology)
Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating wi...
Published on Jan 1, 2010
Melissa Laura Fernandez4
Estimated H-index: 4
Chronic venous leg ulcers are a detrimental health issue plaguing our society, resulting in long term pain, immobility and decreased quality of life for a large proportion of sufferers. The frequency of these chronic wounds has led current research to focus on the wound environment to provide important information regarding the prolonged, fluctuated or static healing patterns of these wounds. Disruption to the normal wound healing process results in release of multiple factors in the wound envir...
Published on Feb 1, 2008
Melissa Laura Fernandez4
Estimated H-index: 4
,
James A. Broadbent7
Estimated H-index: 7
+ 2 AuthorsZee Upton31
Estimated H-index: 31
Background Chronic venous leg ulcers are a significant cause of pain, immobility and decreased quality of life for patients with these wounds. In view of this, research efforts are focused on multiple factors in the wound environment to obtain information regarding the healing of ulcers. Objectives Chronic wound fluid (CWF), containing a complex mixture of proteins, is an important modulator of the wound environment, and therefore we hypothesized that these proteins may be indicators of the stat...
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