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James A. Fagin
Memorial Sloan Kettering Cancer Center
221Publications
72H-index
19.9kCitations
Publications 223
Newest
#1Vera Tiedje (MSK: Memorial Sloan Kettering Cancer Center)
#2James A. Fagin (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 72
Multikinase inhibitors are effective treatments for thyroid cancers, acting primarily as antiangiogenic agents. This year, advances have been made in selective targeting of RET and BRAF in patients with medullary and anaplastic thyroid cancers, respectively. However, Hurthle cell carcinomas have a unique genomic landscape with no dominant truncal drivers, precluding simplistic approaches to therapeutic targeting.
Source
#1Ramesh Paudyal (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 4
#2Yonggang LuH-Index: 8
Last.Amita Shukla-Dave (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 30
view all 16 authors...
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#1Alice Fletcher (University of Birmingham)H-Index: 2
#2Martin L. Read (University of Birmingham)H-Index: 20
Last.Christopher McCabe (University of Birmingham)H-Index: 46
view all 17 authors...
The sodium iodide symporter (NIS) is required for iodide uptake which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer where its ability to transport radioisotopes depends on its localization to the plasma membrane. The advent of NIS-based in vivo imaging and theranostic strategies in other malignancies and disease modalities has recently increased the clinical importance of NIS. However, NIS trafficking ...
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#1Kelly L. Bolton (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 8
#2Ryan Ptashkin (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 7
Last.Elli Papaemmanuil (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
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Clonal hematopoiesis (CH) is frequent in cancer patients and associated with increased risk of therapy related myeloid neoplasms (tMN). To define the relationship between CH, oncologic therapy, and tMN progression, we studied 24,439 cancer patients. We show that previously treated patients have increased rates of CH, with enrichment of mutations in DNA Damage Response (DDR) genes (TP53, PPM1D, CHEK2). Exposure to radiation, platinum and topoisomerase II inhibitors have the strongest association ...
1 CitationsSource
#1Iñigo Landa (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 21
#2Nikita Pozdeyev (Anschutz Medical Campus)H-Index: 16
Last.Rebecca E. Schweppe (Anschutz Medical Campus)H-Index: 17
view all 6 authors...
We read with interest the letter by Garcia and colleagues, as well as their recent publication assessing MET amplification in the anaplastic thyroid cancer (ATC)-derived TTA-1 cell line ([1][1]). In their correspondence, the authors asked whether MET amplification was observed in TTA-1 cells in our
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#1Dilmi Perera (MSK: Memorial Sloan Kettering Cancer Center)
#2Ronald Ghossein (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 60
Last.R. Michael Tuttle (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 58
view all 16 authors...
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#1Iñigo Landa (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 21
#2Nikita Pozdeyev (University of Colorado Denver)H-Index: 5
Last.Rebecca E. Schweppe (University of Colorado Denver)H-Index: 17
view all 16 authors...
Purpose:Thyroid cancer cell lines are valuable models but have been neglected in pan-cancer genomic studies. Moreover, their misidentification has been a significant problem. We aim to provide a validated dataset for thyroid cancer researchers. Experimental Design:We performed next-generation sequencing and analyzed the transcriptome of 60 authenticated thyroid cell lines and compared our findings with the known genomic defects in human thyroid cancers. Results: Unsupervised transcriptomic analy...
4 CitationsSource
#1Rebecca E. Schweppe (Anschutz Medical Campus)H-Index: 17
#2Nikita Pozdeyev (Anschutz Medical Campus)H-Index: 5
Last.Bryan R. Haugen (Anschutz Medical Campus)H-Index: 47
view all 16 authors...
Cancer cell lines are critical models to study tumor progression and response to therapy. In 2008, we showed that approximately 50% of thyroid cancer cell lines were redundant or not of thyroid cancer origin. We therefore generated new authenticated thyroid cancer cell lines and patient-derived xenograft (PDX) models using in vitro and feeder cell approaches, and characterized these models in vitro and in vivo. We developed four thyroid cancer cell lines, two derived from 2 different patients wi...
3 CitationsSource
#1Bin Xu (Sunnybrook Health Sciences Centre)H-Index: 19
#2Ed Reznik (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 29
Last.Ian Ganly (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 44
view all 16 authors...
Purpose In 2016, non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NI-EFVPTC) was renamed as noninvasive thyroid follicular neoplasm with papillary-like nuclear features (NIFTP). However, as the study cohort did not mention tumors with oncocytic features, such lesions are still labeled by some as FVPTC. It is therefore crucial to evaluate the outcome and molecular profile of oncocytic NI-EFVPTC.
3 CitationsSource
#1Gnana P. Krishnamoorthy (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
#2Natalie R. Davidson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last.James A. Fagin (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 72
view all 18 authors...
Translation initiation is orchestrated by the cap binding and 43S pre-initiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC. Recurrent EIF1AX mutations in papillary thyroid cancers are mutually exclusive with other drivers, including RAS. EIF1AX is enriched in advanced thyroid cancers, where it displays a striking co-occurrence with RAS, which cooperates to induce tumorigenesis in mice and isogenic c...
2 CitationsSource
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