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Xinyuan Wan
Sichuan University
MicelleMethacrylateAtom-transfer radical-polymerizationOrganic chemistryDrug delivery
6Publications
4H-index
38Citations
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Publications 6
Newest
#1Yuanyuan He (Sichuan University)H-Index: 3
#2Xinyuan Wan (Sichuan University)H-Index: 4
Last. Qiang Fu (Sichuan University)H-Index: 56
view all 10 authors...
Infections resulting from the attachment of bacteria and biofilm formation on the surface of medical implants give rise to a severe problem for medical device safety. Thus, the development of antibacterial materials that integrate bactericidal and antifouling properties is a promising approach to prevent biomaterial-associated infections. In this study, two types of dopamine-modified polymers, dopamine-terminated quaternary ammonium salt polymer (D-PQAs) with various lengths of N-alkyl chain (D-...
3 CitationsSource
#1Nijia Song (Sichuan University)H-Index: 8
#2Lijuan Zhou (Sichuan University)H-Index: 10
Last. Qiang Fu (Sichuan University)H-Index: 56
view all 11 authors...
Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However, the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood. In this contribution, the actively-targeted PM were developed using trastuzumab as a model targeting group. It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process, while the incorporation of trastu...
3 CitationsSource
#1Nijia Song (Sichuan University)H-Index: 8
#2Lijuan Zhou (Sichuan University)H-Index: 10
Last. Qiang Fu (Sichuan University)H-Index: 56
view all 10 authors...
A multifunctional drug delivery system (DDS) for cancer therapy still faces great challenges due to multiple physiological barriers encountered in vivo. To increase the efficacy of current cancer treatment a new anticancer DDS mimicking the response of nonenveloped viruses, triggered by acidic pH to escape endo-lysosomes, is developed. Such a smart DDS is self-assembled from biodegradable pH-sensitive polyurethane containing hydrazone bonds in the backbone, named pHPM. The pHPM exhibits excellen...
5 CitationsSource
#1Yuanqing Song (Sichuan University)H-Index: 4
#2Yunlong Gao (Sichuan University)H-Index: 4
Last. Qiang Fu (Sichuan University)H-Index: 56
view all 7 authors...
Complications such as thromboembolism and bacterial infection, arising from the widespread use of implanted medical devices, are serious problems for current clinical treatment. In this work, dual-functional anticoagulant and antibacterial blend coatings were designed and fabricated from gemini quaternary ammonium salt waterborne polyurethane (GWPU) emulsion and heparin aqueous solution. The results demonstrate that the L-lysine-derivative gemini quaternary ammonium salt (GQAS) in GWPU endows th...
5 CitationsSource
#1Xinyuan Wan (Sichuan University)H-Index: 4
#2Yuanqing Song (Sichuan University)H-Index: 4
Last. Hong Tan (Sichuan University)H-Index: 29
view all 7 authors...
To improve the sensitive and specific detection of metastasis of lung cancer, this study fabricated immune superparamagnetic iron oxide nanoparticles (SPIONs) used in magnetic resonance (MR) immumoimaging. These SPIONs were coated with oleic acid and carboxymethyl dextran, and then conjugated to mouse anti-CD44v6 monoclonal antibody. The physicochemical properties of magnetic nanoparticles without monoclonal antibody were characterized by X-ray powder diffraction (XRD), thermogravimetric analysi...
7 CitationsSource
#1Xinyuan Wan (Sichuan University)H-Index: 4
#2Yi Zhang (Sichuan University)H-Index: 13
Last. Qiang Fu (Sichuan University)H-Index: 56
view all 9 authors...
In this paper, to investigate the effects of interactions between poly(quaternary ammonium) salts (PQAs) and poly(ethylene glycol) on their mixed micellar surface structures and properties under spontaneous conditions, a series of PQAs were first designed and synthesized by atom transfer radical polymerization (ATRP) using 2-(dimethylamino) ethyl methacrylate (DMAEMA) quaternized by bromobutane, bromooctane, and bromododecane, respectively. Poly(poly(ethylene glycol) methyl ether methacrylate) (...
7 CitationsSource
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