Barton Childs
Johns Hopkins University
DiseaseGeneticsDiabetes mellitusMedicineBiology
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Publications 104
#1Joan M. Finucci (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Catherine C. Whitehouse (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
Last. Barton Childs (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 36
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SUMMARY One hundred and fifty-four adult relatives of children with specific reading disability, and a group of 90 adults matched for age, sex, educational level and IQ, were given a battery of intelligence, reading and spelling tests and a questionnaire on their reading history, habits and attitudes. Data obtained from the latter group were used to derive multiple regression equations for the prediction of reading and spelling scores. An index was derived for each adult, expressing actual score...
42 CitationsSource
SUMMARY An average achievement quotient, based on scores from an individual IQ test, an oral reading test and a spelling test, was calculated for each of 241 randomly selected children in school-grades 3 to 12, and for 46 children attending schools for disabled readers. In the former group the quotient was distributed with the expected mean of 100, whereas all the disabled readers had quotients of 90 or less. All the children also responded to self-report items about their school history, attitu...
33 CitationsSource
#1Barton Childs (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 36
#2William H. Zinkham (Johns Hopkins University)H-Index: 22
#1Kwang-Il GohH-Index: 31
#2Michael E. Cusick (Harvard University)H-Index: 10
Last. Albert-La szlo Baraba si (ND: University of Notre Dame)H-Index: 120
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A network of disorders and disease genes linked by known disorder–gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and disease gene associations, indicating the common genetic origin of many diseases. Genes associated with similar disorders show both higher likelihood of physical interactions between their products and higher expression profiling similarity for their transcripts, supporting the existence of distinct disease-specific functio...
2,133 CitationsSource
6 Citations
#1Barton Childs (Johns Hopkins University)H-Index: 36
#2Charles M WienerH-Index: 1
Last. David ValleH-Index: 61
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This observation was made by observers of the past who saw that because there was no science of the individual, there was no way to treat a patient as an individual. It is not clear what they thought that science of the individual was, but we know what it is today. It is the uniqueness of the individual—genetic, developmental, and experiential—that accounts for human variation, whether in health or disease.
33 CitationsSource
Webster’s dictionary is rich in definitions of the word “education.” Among them are two: First, the act of providing knowledge, skills, and competence, and, second, the act of rearing or bringing up. These two educational goals Dr. Hirschhorn fulfilled abundantly and with remarkable skill, organization, and energy.
#2Barton ChildsH-Index: 36
Last. David Valle (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 61
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The complete human genome sequence will facilitate the identification of all genes that contribute to disease. We propose that the functional classification of disease genes and their products will reveal general principles of human disease. We have determined functional categories for nearly 1,000 documented disease genes, and found striking correlations between the function of the gene product and features of disease, such as age of onset and mode of inheritance. As knowledge of disease genes ...
310 CitationsSource
28 CitationsSource