Mirko H. H. Schmidt
University of Mainz
Molecular biologyAngiogenesisCancer researchBiologyCell biology
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Publications 69
#1Caroline Fischer (Goethe University Frankfurt)H-Index: 3
#2Heiko Endle (University of Mainz)H-Index: 4
Last. Isabel Faria Snodgrass (Goethe University Frankfurt)H-Index: 1
view all 13 authors...
Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-dependent cortical excitability and sensory information processing in mice and humans via presynaptic LPAR2 activation. Here, we studied the consequences of LPAR2 deletion or antagonism on various aspects of cognition using a set of behavioral and electrophysiological analyses. Hippocampal neuronal network activity was decreased in middle-aged LPAR2-/- mice, whereas hippocampal long-term potentiation (LTP) was i...
#1Virginie NeirinckxH-Index: 10
#1V NeirinckxH-Index: 1
Last. Simone P. NiclouH-Index: 38
view all 7 authors...
#1Adrian Kasaj (University of Mainz)H-Index: 21
#2Brita Willershausen (University of Mainz)H-Index: 31
Last. Mirko H. H. Schmidt (Goethe University Frankfurt)H-Index: 29
view all 6 authors...
#1Katja Schmitz (Goethe University Frankfurt)H-Index: 9
#2Annett Wilken-Schmitz (Goethe University Frankfurt)H-Index: 2
Last. Irmgard Tegeder (Goethe University Frankfurt)H-Index: 44
view all 6 authors...
Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a mouse model by a monoclonal antibody aggravates MS-like experimental autoimmune encephalomyelitis (EAE). However, unexpectedly, progranulin-deficient mice (Grn−/−) were resistant to EAE, and this resi...
2 CitationsSource
#1Virginie NeirinckxH-Index: 10
#1V NeirinckxH-Index: 1
Last. Simone P. NiclouH-Index: 38
view all 13 authors...
#1Christine Altmann (University of Mainz)H-Index: 2
#1Christine AltmannH-Index: 5
Last. Mirko H. H. Schmidt (University of Mainz)H-Index: 29
view all 3 authors...
As most common primary brain cancer, glioblastoma is also the most aggressive and malignant form of cancer in the adult central nervous system. Glioblastomas are genetic and transcriptional heterogeneous tumors, which in spite of intensive research are poorly understood. Over the years conventional therapies failed to affect a cure, resulting in low survival rates of affected patients. To improve the clinical outcome, an important approach is to identify the cells of origin. One potential source...
7 CitationsSource
#1Jens Waschke (LMU: Ludwig Maximilian University of Munich)H-Index: 14
#2Martin Bergmann (University of Giessen)H-Index: 46
Last. Friedrich Paulsen (FAU: University of Erlangen-Nuremberg)H-Index: 15
view all 38 authors...
Abstract The practice of human and veterinary medicine is based on the science of anatomy and dissection courses are still irreplaceable in the teaching of anatomy. Embalming is required to preserve body donors, for which process formaldehyde (FA) is the most frequently used and well characterized biocidal substance. Since January 2016, a new occupational exposure limit (OEL) for FA of 0.37 mg/m3 issued by the European Committee on Hazardous Substances is obligatory since FA has been classified ...
4 CitationsSource
#1V NeirinckxH-Index: 1
#2A SchusterH-Index: 3
Last. Simone P. NiclouH-Index: 38
view all 5 authors...
#1Nevenka Dudvarski Stankovic (DKFZ: German Cancer Research Center)H-Index: 4
#2Frank Bicker (DKFZ: German Cancer Research Center)H-Index: 7
Last. Mirko H. H. Schmidt (DKFZ: German Cancer Research Center)H-Index: 29
view all 18 authors...
Abstract Glioblastoma (GBM) is a typically lethal type of brain tumor with a median survival of 15 months postdiagnosis. This negative prognosis prompted the exploration of alternative treatment options. In particular, the reliance of GBM on angiogenesis triggered the development of anti‐VEGF (vascular endothelial growth factor) blocking antibodies such as bevacizumab. Although its application in human GBM only increased progression‐free periods but did not improve overall survival, physicians a...
6 CitationsSource
#1Catherine Larochelle (UdeM: Université de Montréal)H-Index: 14
#2Timo Uphaus (University of Mainz)H-Index: 8
Last. Frauke Zipp (University of Mainz)H-Index: 61
view all 12 authors...
Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis (MS), and in mice with experimental autoimmune encephalomyelitis (EAE). Perivascular CD4 T lymphocytes colocalize with ECM-bound EGFL7 in MS lesions. Human and mouse activated T cells upregulate EGFL7 ligan...
12 CitationsSource