Hang Ma
University of Rhode Island
GlycationChemistryMaple syrupBiochemistryBiology
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Publications 65
Aggregation of misfolded amyloid beta (Aβ) peptides into neurotoxic oligomers and fibrils has been implicated as a key event in the etiopathogenesis of Alzheimer’s disease (AD). Ginnalin A (GA), a polyphenolic compound isolated from the red maple (Acer rubrum), has been found to possess anticancer, anti-glycation, and anti-oxidation properties. Using thioflavin-T (ThT) fluorescence, surface plasmon resonance (SPR), and atomic force microscopy (AFM), we demonstrate that GA can also effectively in...
#1Wen Xu (NU: Northeastern University)
#2Lu Zhang (URI: University of Rhode Island)H-Index: 2
Last. Liya Li (NU: Northeastern University)H-Index: 6
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Four new barringtogenol C-type triterpenoid saponins, namely acerplatanosides A – D (1–4), along with 22 known compounds (5–26), were isolated from the stem bark of Norway maple (Acer platanoides). Their structures were elucidated on the basis of comprehensive spectroscopic analyses and chemical hydrolysis. This is the first report of triterpenoid saponins isolated from Norway maple. Compounds 1, 3, and 4 showed cytotoxicity against 4 human cancer cell lines with IC50 values ranging from 9.4 to ...
#1Yuanyuan Li (NU: Northeastern University)H-Index: 4
#2Dongli Li (Wuyi University)
Last. Liya Li (NU: Northeastern University)H-Index: 6
view all 10 authors...
Reactive oxygen species and subsequent oxidative stress are reported to play important roles in chronic metabolic diseases. Plant-derived polyphenols, especially food-derived phenolics, have attracted a lot of attention due to their potential usage against oxidative stress-related diseases. The leaf of Psidium guajava (known as guava) is regarded as a good resource of polyphenols and its products are commercially available in Japan as functional foods against multiple chronic metabolism disorder...
#1Kenneth N. Rose (URI: University of Rhode Island)H-Index: 3
#2Benjamin J. Barlock (URI: University of Rhode Island)H-Index: 1
Last. Navindra P. Seeram (URI: University of Rhode Island)H-Index: 57
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ABSTRACTObjectives: Alzheimer's disease (AD) is a growing global health crisis exacerbated by increasing life span and an aging demographic. Convergent lines of evidence, including genome-wide asso...
1 CitationsSource
#1Fangyi Chen (URI: University of Rhode Island)H-Index: 9
#2Qi Tang (URI: University of Rhode Island)H-Index: 3
Last. Deyu Li (URI: University of Rhode Island)
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Hydrolyzable tannins are a class of polyphenolic compounds commonly found in natural products. In this work, we studied the in vitro inhibitory mechanism of six molecules in this class on ALKBH2, an Fe(II)/α-ketoglutarate-dependent DNA repair enzyme in the AlkB family. We determined the IC50 values of these compounds on the repair of 3-methylcytosine and 1-methyladenine, the prototypical substrates of ALKBH2. A structure–activity relationship was also observed between the strength of inhibition ...
#1Jialin Xu (NU: Northeastern University)H-Index: 4
#2Tingting Liu (NU: Northeastern University)H-Index: 3
Last. Liya Li (NU: Northeastern University)H-Index: 6
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3 CitationsSource
Increasing evidence supports the beneficial effects of polyphenol-rich diets, including the traditional Mediterranean diet, for the management of cardiovascular disease, obesity and neurodegenerative diseases. However, a common concern when discussing the protective effects of polyphenol-rich diets against diseases is whether these compounds are present in systemic circulation in their intact/parent forms in order to exert their beneficial effects in vivo. Here, we explore two common classes of ...
#1Chang Liu (URI: University of Rhode Island)H-Index: 1
#2Hao Guo (URI: University of Rhode Island)
Last. Hang Ma (URI: University of Rhode Island)H-Index: 12
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Abstract Pomegranate phenolics have been reported to exert skin beneficial effects but their mechanisms of action remain unclear. Herein, we investigated a standardized commercial pomegranate extract (PE; Pomella®) and its phenolics including punicalagin (PA), ellagic acid (EA), and urolithin A (UA) for their protective effects against hydrogen peroxide (H2O2)-induced oxidative stress and cytotoxicity in human keratinocyte HaCaT cells. PE, PA, and EA reduced the production of H2O2-induced ROS in...
#1Min Chen (Wuyi University)
#2Ying Qin (Wuyi University)
Last. Dongli Li (Wuyi University)H-Index: 8
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Acanthopanax trifoliatus (L.) Merr., an edible medicinal plant from Southeast Asia, exerts a wide range of bioactivities, such as anti-inflammatory activity. However, the anti-inflammatory mechanisms of its action and active constituents remain unclear. Herein, the effects of two triterpenoids, namely impressic acid (IA) and acankoreanogenin A (AA), from A. trifoliatus in both in vitro and in vivo chronic inflammation models were investigated. The results indicated that AA and IA reduced lipopol...
#1Nicholas Brotzman (Susquehanna University)H-Index: 1
#2Yiming Xu (URI: University of Rhode Island)H-Index: 1
Last. Geneive E. Henry (Susquehanna University)H-Index: 13
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Abstract Carvacrol (1) and thymol (2) were converted to their alkyl 4-oxobutanoate derivatives (7–20) in three steps, and evaluated for tyrosinase inhibitory activity. The compounds showed structure-dependent activity, with all alkyl 4-oxobutanoates, except 7 and 20, showing better inhibitory activity than the precursor 4-oxobutanoic acids (5 and 6). In general, thymol derivatives exhibited a higher percent inhibitory activity than carvacrol derivatives at 500 μM. Derivatives containing three-ca...
2 CitationsSource