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Hidetoshi Ishibashi
Tokyo Medical University
21Publications
6H-index
130Citations
Publications 21
Newest
#1Ikuo TomiokaH-Index: 11
Last.Terumi NakataniH-Index: 2
view all 27 authors...
Abstract Age-associated neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan. Although various rodent models have been developed to study and overcome these diseases, they have limitations in their translational research utility owing to differences from humans in brain structure and function and in drug metabolism. Here, we generated a transgenic marmoset ...
#1Hiraku Sasaki (Juntendo University)H-Index: 11
#2Hiroki Ishikawa (Showa University)H-Index: 2
Last.Ron BootH-Index: 2
view all 7 authors...
[ Pasteurella ] pneumotropica is a ubiquitous bacterium frequently isolated from laboratory rodents. Although this bacterium causes various diseases in immunosuppressed animals, little is known about major virulence factors and their roles in pathogenicity. To identify virulence factors, we sequenced the genome of [ P. ] pneumotropica biotype Heyl strain ATCC 12555, and compared the resulting non-contiguous draft genome sequence with the genome of biotype Jawetz strain ATCC 35149. Among a large ...
#1Hironori Okada (Nippon Medical School)H-Index: 6
#2Hidetoshi Ishibashi (TMU: Tokyo Medical University)H-Index: 6
Last.Shin'ichi TakedaH-Index: 61
view all 11 authors...
Background: Non-human primates (NHPs) could provide an appropriate model for neuromuscular diseases because of its cognitive function and physiological resemblance to human. Production of transgenic and knockout NHPs from preimplantation embryos by using genomic modification were reported. However, several decades would be required for establishing homozygous and/or phenotypically stable progenies and for developing the symptoms in case of late onset diseases. In contrast, induction of pathology...
#1Hideyuki H. Motohashi (Okayama University)H-Index: 6
#2Hidetoshi Ishibashi (TMU: Tokyo Medical University)H-Index: 6
The ovary of neonatal nonhuman primates contains the highest number of immature oocytes, but its cryopreservation has not yet been sufficiently investigated in all life stages. In the current study, we investigated cryodamage after vitrification/warming of neonatal ovaries from a nonhuman primate, the common marmoset (Callithrix jacchus). A Cryotop was used for cryopreservation of whole ovaries. The morphology of the vitrified/warmed ovaries was found to be equivalent to that of fresh ovaries. N...
The common marmoset has been increasingly used for research in the biomedical field; however, there is little information available regarding effective methods of anesthesia in this species. This study retrospectively analyzed 2 regimens of anesthesia induction: intramuscular injection of ketamine followed by inhalation of 5% sevoflurane, and intramuscular injection of midazolam, butorphanol and ketamine followed by inhalation of 5% sevoflurane. Anesthetic depth did not reach the surgical anesth...
#1Hironori Okada (Nippon Medical School)H-Index: 6
#2Hidetoshi Ishibashi (TMU: Tokyo Medical University)H-Index: 6
Last.Shin'ichi TakedaH-Index: 61
view all 11 authors...
Background: The common marmoset (Callithrix jacchus) could provide an appropriate model for neuromuscular diseases because of its higher brain function and physiological resemblance to human. Although production of transgenic marmosets from zygote transduced with lentiviral vector were reported, this strategy is too costly and not efficient with various reasons. In contrast, an adeno-associated virus vector (rAAV) has great advantages to induce pathology in the aged animals. However, fully matur...
The use of the common marmoset monkey in biomedical research has increased recently, and further attention has been devoted to this model after the successful production of transgenic marmosets. To extend genetic engineering approaches to widespread biomedical research fields, efficient prolonged in vitro culturing of embryo development is necessary. We aimed to evaluate the effects of the size of the zona pellucida opening on promoting the hatching process in the marmoset embryo. Piezo-microdri...
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