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Steve Horvath
University of California, Los Angeles
345Publications
97H-index
38.6kCitations
Publications 362
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#1Audrey Luo (NIH: National Institutes of Health)H-Index: 1
#2Jeesun Jung (NIH: National Institutes of Health)H-Index: 16
Last.Falk W. Lohoff (NIH: National Institutes of Health)H-Index: 29
view all 12 authors...
To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employed Levine’s epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in 331 individuals with AUD and 201 healthy controls (HC). We evaluated the effects of heavy, chronic alcohol consumption on epigenetic age acceleration (EAA) using clinical biomarkers, including liver function test enzymes (LFTs) and clinical measures. To characterize potential underlying genetic variation contributing to EAA i...
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#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Andrew M. McIntosh (Edin.: University of Edinburgh)H-Index: 75
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Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. These include methylation-based predictors of chronological age (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length (DNAm Telomere Length). In this study, we test the association between these epigenetic markers of ageing and the prevalence and inc...
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#1Laura M. Raffield (UNC: University of North Carolina at Chapel Hill)H-Index: 12
#2Ake T. Lu (UCLA: University of California, Los Angeles)H-Index: 18
Last.Marguerite R. Irvin (UAB: University of Alabama at Birmingham)H-Index: 29
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#1Rahul Gondalia (UNC: University of North Carolina at Chapel Hill)H-Index: 8
#2Katelyn M. Holliday (UNC: University of North Carolina at Chapel Hill)H-Index: 5
Last.Eric A. Whitsel (UNC: University of North Carolina at Chapel Hill)H-Index: 31
view all 23 authors...
Background: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-a...
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#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
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Individuals of the same chronological age exhibit disparate rates of biological ageing. Consequently, a number of methodologies have been proposed to determine biological age and primarily exploit variation at the level of DNA methylation (DNAm). A novel epigenetic clock, termed ‘DNAm GrimAge’ has outperformed its predecessors in predicting the risk of mortality as well as many age-related morbidities. However, the association between DNAm GrimAge and cognitive or neuroimaging phenotypes remains...
2 CitationsSource
#1Drew Nannini (NU: Northwestern University)H-Index: 1
#2Brian T. Joyce (NU: Northwestern University)H-Index: 10
Last.Lifang Hou (NU: Northwestern University)H-Index: 44
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The metabolic syndrome (MetS) is a collection of metabolic disturbances that can lead to various cardiovascular diseases. Previous studies have shown a more adverse metabolic risk profile is associated with more advanced biological aging. The associations between epigenetic biomarkers of age with MetS, however, are not well understood. We therefore investigated the associations between epigenetic age acceleration and MetS severity score and incident MetS. A subset of study participants with avai...
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#1Christopher G. Bell (QMUL: Queen Mary University of London)H-Index: 23
#2Robert Lowe (QMUL: Queen Mary University of London)H-Index: 17
Last.Vardhman K. Rakyan (QMUL: Queen Mary University of London)H-Index: 34
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Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of ...
12 CitationsSource
#1Akina Hoshino (UW: University of Washington)H-Index: 3
#2Steve Horvath (UCLA: University of California, Los Angeles)H-Index: 97
Last.Thomas A. Reh (UW: University of Washington)H-Index: 73
view all 5 authors...
Epigenetic changes have been used to estimate chronological age across the lifespan, and some studies suggest that epigenetic “aging” clocks may already operate in developing tissue. To better understand the relationship between developmental stage and epigenetic age, we utilized the highly regular sequence of development found in the mammalian neural retina and a well-established epigenetic aging clock based on DNA methylation. Our results demonstrate that the epigenetic age of fetal retina is ...
2 CitationsSource
#1Sophia Lewis (UCLA: University of California, Los Angeles)H-Index: 1
#2Daniel Nachun (UCLA: University of California, Los Angeles)H-Index: 2
Last.Leanne Jones (UCLA: University of California, Los Angeles)H-Index: 1
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Summary Background and Aims The epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. While the small intestine and colon have distinct, well-characterized physiological functions, it remains unclear if there are fundamental regional differences in stem cell behavior or region-dependent degenerative changes during aging. Mesenchyme-free organoids provide useful tools for investigating intestinal stem cell biology in vitro and have st...
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#1Gregory M. FahyH-Index: 1
#2Robert T. BrookeH-Index: 1
Last.Steve Horvath (UCLA: University of California, Los Angeles)H-Index: 97
view all 10 authors...
9 CitationsSource
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