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Jon F. Harrison
Arizona State University
148Publications
41H-index
5,144Citations
Publications 148
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#1Jon F. Harrison (ASU: Arizona State University)H-Index: 41
#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Simon Werkhoven (ASU: Arizona State University)H-Index: 1
Last.Jon F. Harrison (ASU: Arizona State University)H-Index: 41
view all 3 authors...
Animals vary tremendously in their capacities to survive anoxia, and the mechanisms responsible are poorly understood. Adult Drosophila melanogaster are rapidly paralyzed and survive up to 12 h of ...
#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Paula F. Overby (ASU: Arizona State University)H-Index: 2
Last.Jon F. Harrison (ASU: Arizona State University)H-Index: 41
view all 5 authors...
As the genetic bases to variation in anoxia tolerance are poorly understood, we used the Drosophila Genetics Reference Panel (DGRP) to conduct a genome-wide association study (GWAS) of anoxia tolerance in adult and larval Drosophila melanogaster. Survival ranged from 0-100% in adults exposed to 6 h of anoxia and from 20-98% for larvae exposed to 1 h of anoxia. Anoxia tolerance had a broad-sense heritability of 0.552 in adults and 0.433 in larvae. Larval and adult phenotypes were weakly correlate...
#1Cynthia J. Downs (Hamilton College)H-Index: 8
#2Laura A. Schoenle (Cornell University)H-Index: 9
Last.Lynn B. Martin (USF: University of South Florida)H-Index: 41
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Body size influences many traits including those that affect host competence, the propensity to cause new infections. Here, we employ a new framework to reveal that, for at least two infections, West Nile virus and Lyme disease, large hosts should be more competent than small ones, but their lower abundance could mitigate their impacts on local risk. By contrast, for rabies, small hosts will be disproportionately more competent than large ones, an effect amplified by the higher densities of smal...
#1Mathias V. Ravn (AU: Aarhus University)H-Index: 1
#2Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
Last.Johannes Overgaard (AU: Aarhus University)H-Index: 37
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ABSTRACT When exposed to anoxia, insects rapidly go into a hypometabolic coma from which they can recover when exposed to normoxia again. However, prolonged anoxic bouts eventually lead to death in most insects, although some species are surprisingly tolerant. Anoxia challenges ATP, ion, pH and water homeostasis, but it is not clear how fast and to what degree each of these parameters is disrupted during anoxia, nor how quickly they recover. Further, it has not been investigated which disruption...
Hypometric scaling of aerobic metabolism [larger organisms have lower mass-specific metabolic rates (MR/g)] is nearly universal for interspecific comparisons among animals, yet we lack an agreed up...
#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Mads Kuhlmann Andersen (AU: Aarhus University)H-Index: 6
Last.Jon F. Harrison (ASU: Arizona State University)H-Index: 41
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ABSTRACT Oxygen limitation plays a key role in many pathologies; yet, we still lack a fundamental understanding of the mechanisms responsible for variation in anoxia tolerance. Most vertebrate studies suggest that anoxia tolerance involves the ability to maintain cellular ATP despite the loss of aerobic metabolism. However, insects such as adult Drosophila melanogaster are able to survive long periods of anoxia (LT 50 : ∼8 h) in a hypo-energetic state characterized by low [ATP]. In this study, w...
#1Jon F. HarrisonH-Index: 41
#2Kendra J. Greenlee (NDSU: North Dakota State University)H-Index: 16
Last.Wilco C. E. P. Verberk (Radboud University Nijmegen)H-Index: 24
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Insects can experience functional hypoxia, a situation in which O2 supply is inadequate to meet oxygen demand. Assessing when functional hypoxia occurs is complex, because responses are graded, age and tissue dependent, and compensatory. Here, we compare information gained from metabolomics and transcriptional approaches and by manipulation of the partial pressure of oxygen. Functional hypoxia produces graded damage, including damaged macromolecules and inflammation. Insects respond by compensat...
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