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Colin Selman
University of Glasgow
EndocrinologyOxidative stressAgeingBiochemistryBiology
117Publications
40H-index
6,308Citations
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Publications 120
Newest
#1Roderick N. Carter (Edin.: University of Edinburgh)H-Index: 13
Last. Madara Brice (Edin.: University of Edinburgh)
view all 29 authors...
Impaired hepatic glucose and lipid metabolism are hallmarks of type 2 diabetes. Increased sulfide production from cysteine, or sulfide donor compounds, may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide oxidation pathway (SOP) is critical for maintaining sulfide within a safe physiological range. We show that mice lacking the liver enriched mitochondrial SOP enzyme thiosulfate sulfur transferase (Tst ko mice) exhibit high circulating sulfide, increased gluconeo...
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#1Cristina Sáenz de Miera (UDS: University of Strasbourg)H-Index: 4
#2Matthew Beymer (UDS: University of Strasbourg)
Last. V. Simonncaux (UDS: University of Strasbourg)H-Index: 34
view all 7 authors...
Mus musculus molossinus (MSM) is a wild-derived mouse strain which maintains the ability to synthesize melatonin in patterns reflecting the ambient photoperiod. The objective of this study was to characterize the effects of photoperiodic variation on metabolic and reproductive traits, and the related changes in pituitary-hypothalamic gene expression in MSM mice. MSM mice were kept in long (LP) or short photoperiod (SP) for 6 weeks. Our results demonstrate that MSM mice kept in LP, as compared to...
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#1Jenny Crowe (Glas.: University of Glasgow)H-Index: 3
#2Felicity E. Lumb (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 7
Last. Simon A. Babayan (Glas.: University of Glasgow)H-Index: 17
view all 13 authors...
Improvements in hygiene and health management have driven significant increases in human lifespan over the last 50 years. Frustratingly however, this extension of lifespan has not been matched by equivalent improvements in late-life health, not least due to the global pandemic in type-2 diabetes, obesity and cardiovascular disease, all ageing-associated conditions exacerbated and accelerated by widespread adoption of the high calorie Western diet (HCD). Recently, evidence has begun to emerge tha...
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#1Stephen E. Wilkie (Glas.: University of Glasgow)
#2Lorna Mulvey (Glas.: University of Glasgow)H-Index: 2
Last. Colin Selman (Glas.: University of Glasgow)H-Index: 40
view all 9 authors...
Modulation of the ageing process by dietary restriction (DR) across multiple taxa is well established. While the exact mechanism through which DR acts remains elusive, the gasotransmitter hydrogen sulphide (H2S) may play an important role. We employed a comparative-type approach using females from three ILSXISS recombinant inbred mouse strains previously reported to show differential lifespan responses following 40% DR. Following long-term (10 months) 40% DR, strain TejJ89-reported to show lifes...
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#1Neal J. Dawson (Glas.: University of Glasgow)
#1Neal J. Dawson (Glas.: University of Glasgow)
Last. Neil B. Metcalfe (Glas.: University of Glasgow)H-Index: 71
view all 4 authors...
Physiological investigations of fish gills have traditionally been centered on the two principal functions of the gills, gas exchange and ion regulation. Mitochondrion-rich cells (MRCs) are primarily found within the gill filaments of fish, and are thought to proliferate in order to increase the ionoregulatory capacity of the gill in response to environmentally-induced osmotic challenges. However, surprisingly little attention has been paid to the metabolic function of mitochondria within fish g...
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#1Benjamin P. Lee (University of Exeter)H-Index: 5
#2Lorna Mulvey (Glas.: University of Glasgow)H-Index: 2
Last. Lorna W. Harries (University of Exeter)H-Index: 37
view all 7 authors...
Abstract Dietary restriction (DR) represents one of the most reproducible interventions to extend lifespan and improve health outcomes in a wide range of species, but substantial variability in DR response has been observed, both between and within species. The mechanisms underlying this variation in effect are still not well characterised. Splicing regulatory factors have been implicated in the pathways linked with DR-induced longevity in C. elegans and are associated with lifespan itself in mi...
2 CitationsSource
#1Felicity E. Lumb (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 7
#2Jenny Crowe (Glas.: University of Glasgow)H-Index: 3
Last. William Harnett (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 41
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One of the most rapidly increasing human public health problems is obesity, whose sequelae like type-2 diabetes, represent continuously worsening, life-long conditions. Over the last 15 years, data have begun to emerge from human and more frequently, mouse studies, that support the idea that parasitic worm infection can protect against this condition. We have therefore investigated the potential of two synthetic small molecule analogues (SMAs) of the anti-inflammatory Acanthocheilonema viteae pr...
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#1Paul G. Shiels (Life Sciences Institute)H-Index: 37
#2Sarah J Buchanan (Life Sciences Institute)H-Index: 2
Last. Peter Stenvinkel (KI: Karolinska Institutet)H-Index: 85
view all 4 authors...
Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also appear to share common underpinning features, including low-grade persistent inflammation, phosphate toxicity, diminished Nrf2 activity, a depleted metabolic capability, depressed mitochondrial biogenesis and a low diversity...
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#1Karine Salin (Glas.: University of Glasgow)H-Index: 13
#2Eugenia M. Villasevil (Glas.: University of Glasgow)H-Index: 3
Last. Neil B. Metcalfe (Glas.: University of Glasgow)H-Index: 71
view all 8 authors...
The physiological causes of intraspecific differences in fitness components such as growth rate are currently a source of debate. It has been suggested that differences in energy metabolism may dri...
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#1Michael Wilkinson (Glas.: University of Glasgow)H-Index: 3
#2Colin Selman (Glas.: University of Glasgow)H-Index: 40
Last. J Norman Flynn (HO: Home Office)
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Driven by the longer lifespans of humans, particularly in Westernised societies, and the need to know more about ‘healthy ageing’, ageing mice are being used increasingly in scientific research. Ma...
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