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Rajeevkumar R. Nair
University of Bergen
NeuroscienceLong-term potentiationArc (protein)Dentate gyrusArc (geometry)
9Publications
4H-index
338Citations
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Publications 10
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#1Rajeevkumar R. Nair (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Stefan Blankvoort (NTNU: Norwegian University of Science and Technology)H-Index: 3
Last. Cliff Kentros (UO: University of Oregon)H-Index: 3
view all 4 authors...
Summary While a variety of remarkable molecular tools for studying neural circuits have recently been developed, the ability to deploy them in particular neuronal subtypes is limited by the fact that native promoters are almost never specific enough. We recently showed that one can generate transgenic mice with anatomical specificity surpassing that of native promoters by combining enhancers uniquely active in particular brain regions with a heterologous minimal promoter, an approach we call EDG...
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#1Shinya OharaH-Index: 9
Last. Menno P. WitterH-Index: 43
view all 5 authors...
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#1Rajeevkumar R. Nair (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Stefan Blankvoort (NTNU: Norwegian University of Science and Technology)H-Index: 3
Last. Cliff Kentros (NTNU: Norwegian University of Science and Technology)H-Index: 1
view all 4 authors...
Understanding brain function requires understanding neural circuits at the level of specificity at which they operate. While recent years have seen the development of a variety of remarkable molecular tools for the study of neural circuits, their utility is currently limited by the inability to deploy them in specific elements of native neural circuits, i.e. particular neuronal subtypes. One can obtain a degree of specificity with neuron-specific promoters, but native promoters are almost never ...
1 CitationsSource
#1Eirik Stamland Nilssen (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Bente Jacobsen (NTNU: Norwegian University of Science and Technology)H-Index: 2
Last. Menno P. Witter (NTNU: Norwegian University of Science and Technology)H-Index: 43
view all 7 authors...
Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component of the projection to the dentate gyrus, CA3 and CA2 of the hippocampal formation. This projection has a counterpart originating from stellate cells in layer II of the medial entorhinal cortex (MEC). Available evidence suggests that the two pathways carry different information, exemplified by a difference in spatial tuning of cells in LEC and MEC. The grid cell, a prominent position-modulated cell type present in M...
6 CitationsSource
#1Craig Myrum (University of Bergen)H-Index: 4
#2Jonathan Soule (University of Bergen)H-Index: 8
Last. Clive R. Bramham (University of Bergen)H-Index: 46
view all 11 authors...
Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum transmembrane protein, calnexin. We show interaction between recombinantly-expressed GST-tagged Arc and endogenous calnexin in HEK293, SH-SY5Y neuroblastoma, and PC12 cells. The interaction was dependent on the central linker region of the Arc protein that is also required for endoc...
1 CitationsSource
#1Rajeevkumar R. Nair (University of Bergen)H-Index: 4
#2Sudarshan Patil (University of Bergen)H-Index: 5
Last. Clive R. Bramham (University of Bergen)H-Index: 46
view all 9 authors...
Arc protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are little known. Post-translation modification by small ubiquitin-like modifier (SUMO) proteins has emerged as a major mechanism for regulating protein-protein interactions and function. We first show in cell lines that ectopically expressed Arc undergoes mono-SUMOylation. The covalent addition of a single SUMO1 protein was confirmed...
23 CitationsSource
#1Malgorzata Hanna Hall (Nencki Institute of Experimental Biology)H-Index: 2
#2Adriana Magalska (Nencki Institute of Experimental Biology)H-Index: 14
Last. Grzegorz M. Wilczynski (Nencki Institute of Experimental Biology)H-Index: 20
view all 15 authors...
PML is a tumor suppressor protein involved in the pathogenesis of promyelocytic leukemia. In non-neuronal cells, PML is a principal component of characteristic nuclear bodies. In the brain, PML has been implicated in the control of embryonic neurogenesis, and in certain physiological and pathological phenomena in the adult brain. Yet, the cellular and subcellular localization of the PML protein in the brain, including its presence in the nuclear bodies, has not been investigated comprehensively....
7 CitationsSource
#1Clive R. Bramham (University of Bergen)H-Index: 46
#2Maria Nordheim Alme (University of Bergen)H-Index: 7
Last. Karin Wibrand (University of Bergen)H-Index: 15
view all 11 authors...
Source
#1Clive R. Bramham (University of Bergen)H-Index: 46
#2Maria Nordheim Alme (University of Bergen)H-Index: 7
Last. Karin Wibrand (University of Bergen)H-Index: 15
view all 11 authors...
The immediate early gene Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. Here, we attempt to overview the Arc system spanning from transcriptional regulation of the Arc gene, to dendritic transport, metabolism, and translation of Arc mRNA, to post-translational modification, localization, and degradation of Arc protein. Within this framework we discu...
299 CitationsSource
1 CitationsSource
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