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Stephane L. Bourque
University of Alberta
OffspringEndocrinologyPregnancyDiabetes mellitusMedicine
47Publications
13H-index
507Citations
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Publications 75
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#1Forough Jahandideh (U of A: University of Alberta)H-Index: 5
#2Stephane L. Bourque (U of A: University of Alberta)H-Index: 13
Last. Jerome Y. Yager (U of A: University of Alberta)H-Index: 26
view all 8 authors...
Stressors during the fetal and postnatal period affect the growth and developmental trajectories of offspring, causing lasting effects on physiologic regulatory systems. Here, we tested whether reduced uterine artery blood flow in late pregnancy would alter body composition in the offspring, and whether feeding offspring a western diet (WD) would aggravate these programming effects. Pregnant rats underwent bilateral uterine artery ligation (BUAL) or sham surgery on gestational day (GD)18 (term =...
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#1Hannah Roberts (UWO: University of Western Ontario)
#2Andrew G. Woodman (U of A: University of Alberta)H-Index: 2
Last. Stephen J. Renaud (UWO: University of Western Ontario)
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#1Ran Wei (U of A: University of Alberta)H-Index: 2
#2S. L. Gust (U of A: University of Alberta)H-Index: 2
Last. James R. Hammond (U of A: University of Alberta)H-Index: 18
view all 9 authors...
Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5-hydroxytryptamine (5-HT) and adenosine across cell membranes. We hypothesized that loss of ENT4 function in mice would modify the effects of these established regulators of vascular function. Male and female wild-type (WT) and slc29a4-null (ENT4-KO) mice were compared with respect to their hemodynamics and mesenteric vascular function. Male ENT4-KO mice had a complete loss of myogenic tone in their mes...
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#1Andrew G. Woodman (U of A: University of Alberta)H-Index: 2
#2Richard Mah (U of A: University of Alberta)H-Index: 2
Last. Stephane L. BourqueH-Index: 13
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2 CitationsSource
#1Andrew G. Woodman (U of A: University of Alberta)H-Index: 2
#2Ronan M. N. Noble (U of A: University of Alberta)H-Index: 2
Last. Stephane L. BourqueH-Index: 13
view all 5 authors...
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#1Oluwatobiloba Osikoya (University of North Texas Health Science Center)H-Index: 1
#2Hijab Ahmed (University of North Texas Health Science Center)H-Index: 1
Last. Styliani Goulopoulou (University of North Texas Health Science Center)H-Index: 22
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#1David M. Fergusson (Ottawa Hospital Research Institute)H-Index: 132
#2Marc T. Avey (Ottawa Hospital Research Institute)H-Index: 13
Last. Manoj M. LaluH-Index: 19
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Poor reporting quality may contribute to irreproducibility of results and failed ‘bench-to-bedside’ translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies. To examine the impact of such guidelines on core methodological and analytical reporting items in the preclinical anesthesiology literature, we sampled a cohort of studies. Preclinical in vivo studies published in Anesthesiology, Anesthesia & Analgesia, Anaest...
1 CitationsSource
#1Lesley J. Brennan (U of A: University of Alberta)H-Index: 6
#2Styliani Goulopoulou (University of North Texas Health Science Center)H-Index: 22
Last. Stephane L. Bourque (U of A: University of Alberta)H-Index: 13
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Abstract Cardiovascular diseases (CVD) are a leading cause of mortality worldwide. Despite recognizing the importance of risk factors in dictating CVD susceptibility and onset, patient treatment remains a challenging endeavor. Increasingly, the benefits of prevention and mitigation of risk factors earlier in life are being acknowledged. The developmental origins of health and disease posits that insults during specific periods of development can influence long-term health outcomes; this occurs b...
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#1Analia S. Loria (UK: University of Kentucky)H-Index: 14
#2Styliani Goulopoulou (University of North Texas Health Science Center)H-Index: 22
Last. Sandra T. Davidge (U of A: University of Alberta)H-Index: 54
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Abstract The developmental origins of health and disease (DOHaD) theory posits that suboptimal environments in utero and/or early postnatal life can cause structural and functional changes in key organ systems, thereby predisposing the individual to chronic disease in later life. Epidemiological, clinical, and preclinical studies show that the cardiovascular, metabolic, and neuroendocrine systems of the offspring can be influenced by environmental factors per se, or maternal responses to such st...
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#2Hijab AhmedH-Index: 1
Last. Styliani GoulopoulouH-Index: 22
view all 5 authors...
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