Aneesh K. Mehta
Emory University
Publications 82
#1Stephanie M. Pouch (Emory University)
#2Shalika B. Katugaha (Inova Fairfax Hospital)H-Index: 1
Last.Julu Bhatnagar (CDC: Centers for Disease Control and Prevention)H-Index: 21
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#1Carl W. Davis (Emory University)H-Index: 17
#2Katherine J. L. Jackson (Stanford University)H-Index: 17
Last.César G. Albariño (CDC: Centers for Disease Control and Prevention)H-Index: 28
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Summary Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 rapidly declining, and IgG4 appearing late. Striking changes occurred in the immunoglobulin repertoire, with massive recruitment of naive B cells that subsequently underwent ...
#1Jens H. Kuhn (NIH: National Institutes of Health)H-Index: 41
#2Takuya AdachiH-Index: 4
Last.Nahid Bhadelia (BU: Boston University)H-Index: 7
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The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.
#1Amy Sherman (Emory University)H-Index: 1
#2Aneesh K. Mehta (Emory University)H-Index: 25
Last.Nadine Rouphael (Emory University)H-Index: 19
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Objectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for influenza was performed, with the goal of assessing safety and ethics and determining how these studies have led to therapeutic and vaccine development. A systematic review of systems biology approaches for the study of influenza was also performed, with a focus on h...
#1Shivaprakash Gangappa (National Center for Immunization and Respiratory Diseases)H-Index: 28
#2Jens Wrammert (Emory University)H-Index: 28
Last.Suryaprakash Sambhara (National Center for Immunization and Respiratory Diseases)H-Index: 33
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Abstract Annual vaccination is routinely used in organ transplant recipients for immunization against seasonal influenza. However, detailed analysis of the kinetics of vaccine-induced immune responses in this population is lacking. In this study, we investigated the kinetics of vaccine strains-specific antibody responses to trivalent influenza vaccine in a group of renal transplant recipients and a control group. First, we found that the geometric mean hemagglutination inhibition titer against a...
#1Colleen S. Kraft (Emory University)H-Index: 23
#2Mark G. Kortepeter (UNMC: University of Nebraska Medical Center)H-Index: 1
Last.Aneesh K. Mehta (Emory University)H-Index: 25
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The 2013-2016 epidemic of Ebola virus disease (EVD) that originated in West Africa underscored many of the challenges to conducting clinical research during an ongoing infectious disease epidemic, ...