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Baohua Wang
University of British Columbia
7Publications
6H-index
292Citations
Publications 7
Newest
David M. Ansley19
Estimated H-index: 19
(UBC: University of British Columbia),
Koen Raedschelders7
Estimated H-index: 7
(Cedars-Sinai Medical Center)
+ 3 AuthorsDavid D. Y. Chen31
Estimated H-index: 31
(UBC: University of British Columbia)
Purpose The efficacy of myocardial conditioning strategies is compromised in patients with advanced age, diabetes, or low ejection fraction. We conducted a single-centre parallel-arm blinded randomized-controlled trial to determine whether propofol provides perioperative myocardial protection.
Published on May 1, 2014
Jayant Shravah3
Estimated H-index: 3
(UBC: University of British Columbia),
Baohua Wang6
Estimated H-index: 6
(UBC: University of British Columbia)
+ 4 AuthorsDavid M. Ansley19
Estimated H-index: 19
(UBC: University of British Columbia)
We previously demonstrated that propofol, an intravenous anesthetic with anti-oxidative properties, activated the phosphoinositide 3-kinase (PI3K)/AKT pathway to increase the expression of B cell lymphoma (Bcl)-2 and, therefore the anti-apoptotic potential on cardiomyocytes. Here, we wanted to determine if propofol can also activate the Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway, another branch of cardioprotective signaling. The cellular response of nu...
Published on Jan 1, 2013in The Journal of Pathology 5.94
David M. Ansley19
Estimated H-index: 19
(UBC: University of British Columbia),
Baohua Wang6
Estimated H-index: 6
(UBC: University of British Columbia)
Reactive oxygen or nitrogen species play an integral role in both myocardial injury and repair. This dichotomy is differentiated at the level of species type, amount, duration of free radical generated. Homeostatic mechanisms designed to prevent free radical generation in the first instance, scavenge, or enzymatically convert them to less toxic forms and water, play crucial roles in maintenance of cellular structure and function. The outcome between functional recovery and dysfunction is depende...
Published on Jun 1, 2011in Clinical Endocrinology 2.90
Baohua Wang6
Estimated H-index: 6
,
Koen Raedschelders7
Estimated H-index: 7
+ 7 AuthorsDavid M. Ansley19
Estimated H-index: 19
Summary Objective Patients with diabetes experience increased cardiovascular complications after cardiac surgery. Hyperglycaemia predicts increased mortality after myocardial infarction and may influence cardiovascular risk in humans. Impaired prosurvival phosphatase and tensin homologue on chromosome 10 (PTEN)-Akt signalling could be an important feature of the diabetic heart rendering it resistant to preconditioning. This study was designed to evaluate for differences and relationships of myoc...
Published on Nov 1, 2009in Biochemical and Biophysical Research Communications 2.71
Baohua Wang6
Estimated H-index: 6
(UBC: University of British Columbia),
Jayant Shravah3
Estimated H-index: 3
(UBC: University of British Columbia)
+ 3 AuthorsDavid M. Ansley19
Estimated H-index: 19
(UBC: University of British Columbia)
Abstract Propofol is a widely used intravenous anesthetic agent with antioxidant properties secondary to its phenol based chemical structure. Treatment with propofol has been found to attenuate oxidative stress and prevent ischemia/reperfusion injury in rat heart. Here, we report that propofol protects cardiac H9c2 cells from hydrogen peroxide (H 2 O 2 )-induced injury by triggering the activation of Akt and a parallel up-regulation of Bcl-2. We show that pretreatment with propofol significantly...
Published on Oct 1, 2007in Anesthesia & Analgesia 3.49
Baohua Wang6
Estimated H-index: 6
,
Tao Luo2
Estimated H-index: 2
+ 1 AuthorsDavid M. Ansley19
Estimated H-index: 19
BACKGROUND:Vascular endothelial cells play an important role in maintaining cardiovascular homeostasis. Oxidative stress is a critical pathogenic factor in endothelial cell damage and the development of cardiovascular diseases. In this study we evaluated the effects of propofol on oxidative stress-i
David M. Ansley19
Estimated H-index: 19
(UBC: University of British Columbia),
Baohua Wang6
Estimated H-index: 6
,
Tao Luo3
Estimated H-index: 3
1