Match!
Baohua Wang
University of British Columbia
7Publications
6H-index
302Citations
Publications 7
Newest
#1David M. Ansley (UBC: University of British Columbia)H-Index: 20
#2Koen Raedschelders (Cedars-Sinai Medical Center)H-Index: 8
Last.David D. Y. Chen (UBC: University of British Columbia)H-Index: 32
view all 6 authors...
Purpose The efficacy of myocardial conditioning strategies is compromised in patients with advanced age, diabetes, or low ejection fraction. We conducted a single-centre parallel-arm blinded randomized-controlled trial to determine whether propofol provides perioperative myocardial protection.
15 CitationsSource
#1Jayant Shravah (UBC: University of British Columbia)H-Index: 3
#2Baohua Wang (UBC: University of British Columbia)H-Index: 6
Last.David M. Ansley (UBC: University of British Columbia)H-Index: 20
view all 7 authors...
We previously demonstrated that propofol, an intravenous anesthetic with anti-oxidative properties, activated the phosphoinositide 3-kinase (PI3K)/AKT pathway to increase the expression of B cell lymphoma (Bcl)-2 and, therefore the anti-apoptotic potential on cardiomyocytes. Here, we wanted to determine if propofol can also activate the Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway, another branch of cardioprotective signaling. The cellular response of nu...
17 CitationsSource
#1David M. Ansley (UBC: University of British Columbia)H-Index: 20
#2Baohua Wang (UBC: University of British Columbia)H-Index: 6
Reactive oxygen or nitrogen species play an integral role in both myocardial injury and repair. This dichotomy is differentiated at the level of species type, amount, duration of free radical generated. Homeostatic mechanisms designed to prevent free radical generation in the first instance, scavenge, or enzymatically convert them to less toxic forms and water, play crucial roles in maintenance of cellular structure and function. The outcome between functional recovery and dysfunction is depende...
111 CitationsSource
#1Baohua WangH-Index: 6
#2Koen RaedscheldersH-Index: 8
Last.David M. AnsleyH-Index: 20
view all 10 authors...
Summary Objective Patients with diabetes experience increased cardiovascular complications after cardiac surgery. Hyperglycaemia predicts increased mortality after myocardial infarction and may influence cardiovascular risk in humans. Impaired prosurvival phosphatase and tensin homologue on chromosome 10 (PTEN)-Akt signalling could be an important feature of the diabetic heart rendering it resistant to preconditioning. This study was designed to evaluate for differences and relationships of myoc...
25 CitationsSource
#1Baohua Wang (UBC: University of British Columbia)H-Index: 6
#2Jayant Shravah (UBC: University of British Columbia)H-Index: 3
Last.David M. Ansley (UBC: University of British Columbia)H-Index: 20
view all 6 authors...
Propofol is a widely used intravenous anesthetic agent with antioxidant properties secondary to its phenol based chemical structure. Treatment with propofol has been found to attenuate oxidative stress and prevent ischemia/reperfusion injury in rat heart. Here, we report that propofol protects cardiac H9c2 cells from hydrogen peroxide (H 2 O 2 )-induced injury by triggering the activation of Akt and a parallel up-regulation of Bcl-2. We show that pretreatment with propofol significantly protects...
83 CitationsSource
#1Baohua WangH-Index: 6
#2Tao LuoH-Index: 45
Last.David M. AnsleyH-Index: 20
view all 4 authors...
BACKGROUND:Vascular endothelial cells play an important role in maintaining cardiovascular homeostasis. Oxidative stress is a critical pathogenic factor in endothelial cell damage and the development of cardiovascular diseases. In this study we evaluated the effects of propofol on oxidative stress-i
51 CitationsSource
#1David M. Ansley (UBC: University of British Columbia)H-Index: 20
#2Baohua WangH-Index: 6
Last.Tao LuoH-Index: 45
view all 3 authors...
Source
1