Jaideep Kapur
University of Virginia
Hippocampal formationGABAA receptorNeuroscienceStatus epilepticusEpilepsy
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Publications 126
#1Suchitra Joshi (UVA: University of Virginia)H-Index: 8
#2William H. Roden (Seattle Children's Research Institute)H-Index: 5
Last. Laura A. Jansen (UVA: University of Virginia)H-Index: 13
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OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating gamma-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is altered. We tested whether similar changes occur in patients with epilepsy and if depolarization-induced increases in neuronal activity can replicate this effect. METHODS: We determined GABAR alpha4 subunit expression in cortical tissue resected f...
#2Jaideep Kapur (UVA: University of Virginia)H-Index: 36
Last. Daniel H. Lowenstein (UCSF: University of California, San Francisco)H-Index: 70
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Summary Background Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in ...
1 CitationsSource
#1Jaideep KapurH-Index: 36
#2Robert SilbergleitH-Index: 25
Last. Jordan J. ElmH-Index: 22
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1 Citations
#1Michael I. Dougherty (UVA: University of Virginia)
#2Katherine Zarroli (UVA: University of Virginia)
Last. Jaideep Kapur (UVA: University of Virginia)H-Index: 36
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#1Nadia AdoteviH-Index: 1
#2Ewa LewczukH-Index: 1
Last. Jaideep KapurH-Index: 36
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OBJECTIVE: Generalized convulsive status epilepticus is associated with high mortality. We tested whether alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor plasticity plays a role in sustaining seizures, seizure generalization, and mortality observed during focal onset status epilepticus. We also determined whether modified AMPA receptors generated during status epilepticus could be targeted with a drug. METHODS: Electrically induced status epilepticus was characterized by...
2 CitationsSource
#1Hannah R. Cock (St George’s University Hospitals NHS Foundation Trust)H-Index: 17
#2Lisa D. Coles (UMN: University of Minnesota)H-Index: 10
Last. Jaideep Kapur (UVA: University of Virginia)H-Index: 36
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Abstract Convulsive status epilepticus (SE) is a relatively common emergency condition affecting individuals of all ages. The primary goal of treatment is prompt termination of seizures. Where first-line treatment with benzodiazepine has failed to achieve this, a condition known as established SE (ESE), there is uncertainty about which agent to use next. The Established Status Epilepticus Treatment Trial (ESETT) is a 3-arm (valproate (VPA), fosphenytoin (FOS), levetiracetam (LEV)), phase III, do...
#1Jennifer Burnsed (UVA: University of Virginia)H-Index: 2
Last. Jaideep Kapur (UVA: University of Virginia)H-Index: 36
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#1Anastasia Brodovskaya (UVA: University of Virginia)H-Index: 1
#2Jaideep Kapur (UVA: University of Virginia)H-Index: 36
Abstract Mapping the circuits underlying the generation and propagation of seizures is critically important for understanding their pathophysiology. We review evidence to suggest that circuits engaged in secondarily generalized seizures are likely to be more complex than those currently proposed. Focal seizures have been proposed to engage canonical thalamocortical circuits that mediate primarily generalized absence seizures, leading to secondarily generalized tonic–clonic seizures. In addition ...
1 CitationsSource
#1John Williamson (UVA: University of Virginia)H-Index: 23
#2Tanveer Singh (UVA: University of Virginia)
Last. Jaideep Kapur (UVA: University of Virginia)H-Index: 36
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Abstract This review summarizes the efforts of our laboratories to develop a mechanism-based therapy for the treatment of organophosphate (OP) nerve agent-induced seizures. Organophosphate poisoning can occur during warfare and terrorist attacks and in the civilian sphere because of intentional or unintentional poisoning. Persons exposed to OPs experience seizures. We developed animal models of OP poisoning and then evaluated the effects of OP on excitatory α-amino-3-hydroxy-5-methyl-4-isoxazole...
#1Abhishek G. Sathe (UMN: University of Minnesota)H-Index: 1
#2Holly Tillman (MUSC: Medical University of South Carolina)H-Index: 7
Last. James C. Cloyd (UMN: University of Minnesota)H-Index: 16
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Benzodiazepines, including diazepam (DZP), lorazepam (LZP), and midazolam (MDZ), are considered the initial drugs of choice for status epilepticus (SE) treatment. A number of trials have demonstrated their safety and efficacy; however, the failure rate ranges from 10‐55%.1,2 This may be attributable, in part, to sub‐optimal benzodiazepine dosing and timing of administration. The Neurocritical Care Society (NCS) and American Epilepsy Society (AES) have published evidence‐based guidelines for benz...
1 CitationsSource