Jinwook Shin
Duke University
Publications 40
#2Jihyun Song (IIT: Inha University)
Last.Jinwook Shin (IIT: Inha University)H-Index: 18
view all 4 authors...
Abstract Colistin is a last-resort antimicrobial against multidrug-resistant gram-negative bacteria. The occurrence and spread of colistin resistance in humans and animals have been reported globally. In the present study, we investigated the prevalence and antimicrobial susceptibility of mcr-harboring colistin-resistant Enterobacteriaceae from retail vegetables and food animals in South Korea in 2018. The mcr-1 gene was detected in Escherichia coli isolates from 0.076% (1/1,324) of vegetables, ...
Abstract Mast cells express high-affinity IgE receptor (FceRI) on their surface, cross-linking of which leads to the immediate release of proinflammatory mediators such as histamine but also late-phase cytokine secretion, which are central to the pathogenesis of allergic diseases. Despite the growing evidences that mammalian target of rapamycin (mTOR) plays important roles in the immune system, it is still unclear how mTOR signaling regulates mast cell function. In this study, we investigated th...
#1Valeriya Rakhmanova (IIT: Inha University)
#2Mirim Jin (Gachon University)H-Index: 15
Last.Jinwook Shin (IIT: Inha University)H-Index: 18
view all 3 authors...
#1Jinwook Shin (IIT: Inha University)H-Index: 18
#2Mirim Jin (Gachon University)H-Index: 15
7 CitationsSource
#1Hyunbin D. Huh (Yonsei University)H-Index: 2
#2Eun Hye Lee (Yonsei University)H-Index: 6
Last.Sung-Wook LeeH-Index: 15
view all 5 authors...
Abstract Toll-like receptor (TLR) signaling drives the innate immune response by activating nuclear factor-κB (NF-κB) and interferon regulatory factor (IRF). We have previously shown that STRAP interacts with TAK1 and IKKα along with NF-κB subunit p65, leading to the activation of pro-inflammatory cytokines. However, the roles of STRAP in TRIF/TBK1-mediated TLR3 activation and the subsequent type I interferon (IFN) production are not fully elucidated. Here, we demonstrate that STRAP acts as a sc...
1 CitationsSource
#1Hyung Chul Lee (IIT: Inha University)H-Index: 11
#2Nam Gu Her (KU: Korea University)H-Index: 6
Last.Jae Seon Lee (IIT: Inha University)H-Index: 20
view all 11 authors...
Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
7 CitationsSource
#1Wenhai Deng (WMU: Wenzhou Medical College)H-Index: 2
#2Jialong Yang (Duke University)H-Index: 24
Last.Xiao-Ping Zhong (Duke University)H-Index: 30
view all 6 authors...
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did no...
9 CitationsSource
#1Min-Ji Seo (SNU: Seoul National University)H-Index: 3
#2Seong-Ok Lee (SNU: Seoul National University)H-Index: 2
Last.Kwangseog Ahn (SNU: Seoul National University)H-Index: 25
view all 10 authors...
The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the redistribution of key signaling molecules to punctate perinuclear structures, but the mediators of this spatiotemporal regulation have yet to be defined. Here we identify butyrophil...
9 CitationsSource
#1Hongxia Wang (Southern Medical University)H-Index: 6
#2Jinwook Shin (Duke University)H-Index: 18
Last.Xiao-Ping Zhong (Duke University)H-Index: 30
view all 8 authors...
Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are controlled is poorly understood. We report here that mTOR complex 1 (mTORC1) in TECs plays critical roles in thymopoiesis and thymus function. Acute deletion of mTORC1 in adult mice caused severe thymic involution. TEC-specific deficiency of mTORC1 (mTORC1KO) impaired T...
10 CitationsSource
#1Wei Yang (UCI: University of California, Irvine)H-Index: 1
#2Balachandra K. Gorentla (Duke University)H-Index: 14
Last.Jinwook Shin (IIT: Inha University)H-Index: 18
view all 4 authors...
Invariant NKT (iNKT) cells, which express the invariant Vα14Jα18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalia...
9 CitationsSource